Results 171 to 180 of about 11,456,586 (404)

An ionic liquid nanoparticles for dermal targeted delivery and effective anti-wrinkle treatment

open access: yesJournal of Dermatologic Science and Cosmetic Technology
Background: Aging is a natural process that cannot be stopped but retarded. Hydroxypinacolone retinoate (HPR) is a potent anti-wrinkle agent, but with severe irritancy, low stability, and poor water solubility, making it hard to apply in cosmetics. Ionic
Huixian Xu   +8 more
doaj   +1 more source

International Control of Raw Materials

open access: green, 1931
Asher Hobson   +2 more
openalex   +2 more sources

Preparation and characterization of renal cell peptides from fetal rats for their antitumor activity

open access: yesFEBS Open Bio, EarlyView.
This study aimed to prepare renal cells (RCs) from fetal rats which were digested by enzymes. Candidate peptides RCPs were characterized by capillary HPLC and MS and their bioactivity was predicted using peptideranker. The predicted top 10 bioactive peptides were synthesized.
Zhe Zhang   +6 more
wiley   +1 more source

Blocking the voltage‐gated sodium channel hNav1.5 as a novel pH‐dependent mechanism of action for tamoxifen

open access: yesFEBS Open Bio, EarlyView.
Patch‐clamp recordings revealed that tamoxifen inhibits voltage‐gated sodium channels, especially under acidic conditions, both common in metastatic cancer cells. These effects may explain certain antitumor properties of tamoxifen, highlighting a novel mechanism of action beyond its known endocrine effects.
Karl Josef Föhr   +5 more
wiley   +1 more source

An optimized protocol to detect high‐throughput DNA methylation from custom targeted sequences on 96 samples simultaneously

open access: yesFEBS Open Bio, EarlyView.
Workflow of a high‐throughput technology for epigenotyping of differentially methylated CpGs in specific regions of the genome. The protocol works with small amounts of DNA extracted from blood or semen. The protocol consists of both enzymatic conversion of unmethylated cytosines and capture by hybridization with a custom panel.
Nathalie Iannuccelli   +4 more
wiley   +1 more source

Numerical analysis of building damage caused by the exposure of a terrain threshold as a result of underground mining-induced subsidence

open access: yesScientific Reports
Underground mining exploitation causes deformations on the ground surface as a result of the filling of the resulting voids. In certain situations, apart from mild continuous deformations, discontinuous deformations may occur in the form of, e.g., steps ...
Leszek Szojda, Piotr Strzałkowski
doaj   +1 more source

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