Results 11 to 20 of about 471 (99)

An Indole Dearomatization Strategy for the Synthesis of Pseudo-Natural Products. [PDF]

Chembiochem
An indole‐dearomatization/reduction strategy is developed to expand a collection of indole‐containing pseudo‐NPs. This approach enhances the three‐dimensionality of the original compound classes through hybridization‐changing conversions leading to topologically distinct novel structures.
Hoock JGF, Burhop A, Greiner LC, Schölermann B, Da Cruz Lopes Guita C, Liu J, Bag S, Pahl A, Sievers S, Scheel R, Strohmann C, Ziegler S, Grigalunas M, Waldmann H.   +13 more
europepmc   +2 more sources

(De)centralized Water Futures: Key Dimensions of Infrastructure, Governance, and Operations. [PDF]

WIREs Water
Schematic of key dimensions visualized as a cube with governance, infrastructure, and operations & maintenance as the three axes with “Decentralized” and “Centralized” on each end. The cube is surrounded by a circle reflecting the broader political‐economic and hydro‐climatic context.
Cooperman AD, Rempel JL, Adams EA, Cantor A, Fuerte MM, Osborne-Gowey J, Wilson NJ, Workman CL, Beresford M, Harris LM, Méndez-Barrientos LE, Shah SH, Wutich A, Stoler J.   +13 more
europepmc   +2 more sources

Bioaccumulation of selected metals in Lamproglena clariae Fryer, 1956 infecting Clarias gariepinus (Burchell, 1822) collected from six sampling sites along the Vaal River, South Africa. [PDF]

Water Environ Res
The paper reports on the ability of a Crustacean fish ectoparasitic to accumulate metals. The concentration of various metals in the parasite is compared to the concentration in the water and sediment in six localities along an anthropogenically impacted river.
Pretorius M, Gradwohl A, Windisch J, Jirsa F, Avenant-Oldewage A.   +4 more
europepmc   +2 more sources

Agricultural Drought Response in Temperate Climates Requires Institutional Development and Coordination to Support Adaptation

Water Resources Research, Volume 62, Issue 10, October 2026.
Abstract Droughts and dry periods represent a novel and emerging threat to agriculture in historically water rich, temperate regions, such as the Northeast United States. Water governance institutions to manage water quantity in these regions are underdeveloped in the context of current needs.
Rachel E. Schattman, Courtney Hammond Wagner, Sara Delaney, Janica Anderzén   +3 more
wiley   +1 more source

Targeting the noncatalytic activity of GSK3β modulates neuronal excitability in medium spiny neurons via Nav1.6 interactions

British Journal of Pharmacology, Volume 183, Issue 15, Page 4344-4363, August 2026.
Abstract Background and Purpose Kinases phosphorylate ion channels, but their noncatalytic roles via protein–protein interactions (PPI) are less understood. Here, we identified the peptidomimetic ZL141 to characterize the PPI between GSK3β and Nav1.6, revealing a noncatalytic role for GSK3β in regulating Nav1.6 currents and neuronal excitability ...
Aditya K. Singh, Zahra Haghighijoo, Akanksha Gurtu, Nolan M. Dvorak, Timothy J. Baumgartner, Nana A. Goode, Jully Singh, Matteo Bernabucci, Adam T. Szafran, Michael J. Bolt, Michael A. Mancini, Natalie M. Dvorak, Marijn Lijffijt, Zhiqing Liu, Yu Xue, Alyssa K. Thomas, Alejandro Villasante‐Tezanos, Balaji Krishnan, Jia Zhou, Fernanda Laezza   +19 more
wiley   +1 more source

Alkaline‐Earth Metal Complexes Based on Tridentate β‐Diketiminate Ligands Bearing a Tethered Secondary Amine: Synthesis and Characterization

Zeitschrift für anorganische und allgemeine Chemie, Volume 652, Issue 11, 16 July 2026.
Deprotonotion of a β‐diketiminate ligand with a tethered secondary amine resulted in highly stable heteroleptic complexes, but the formation of the dianionic ligand could not be achieved. The alkaline‐earth (Ae) metal chemistry of a β‐diketiminate (BDI) ligand with a bulky Ar‐substituent and a pendant amine arm was investigated. The ligand precursor HC[
Bastian Rösch, Jefferson Guzmán, Heiko Bauer, Jürgen Pahl, Michael Wiesinger, Ana Escalona, Sjoerd Harder   +6 more
wiley   +1 more source

Advanced Extractables and Leachables Assessment of Microcarriers Used for Adherent Cell Cultures

Biotechnology Journal, Volume 21, Issue 4, April 2026.
Graphical Abstract and Lay Summary We present a comprehensive workflow for the Extractables and Leachables (E & L) assessment of microcarriers used in adherent cell culture. Four key components are appied: experimental extractables testing (USP <665>), modelling of extractables release, process modelling, and safety assessment via biocompatibility and ...
Armin Hauk, Ina Pahl, Jonas Austerjost, Julia Hupfeld, Julia Bernfeld, Antonina Lavrentieva, Roberto Menzel   +6 more
wiley   +1 more source

Autocorrelation‐Based Imaging of Crustal Discontinuities Including the Main Himalayan Thrust and Vp/Vs Ratio in the Jammu and Kashmir Himalaya

Journal of Geophysical Research: Solid Earth, Volume 131, Issue 4, April 2026.
Abstract The Jammu and Kashmir Himalaya, located between the rupture zones of the 1905 Kangra and 2005 Kashmir earthquakes, represent a prominent “seismic gap” where understanding the subsurface structure is critical for seismic hazard assessment. This study presents new insights into the crustal structure of this region using teleseismic P‐wave coda ...
Hari Ram Thapa, Supriyo Mitra, Abdelkrim Aoudia, Gordana Vlahovic, Keith Priestley, Sunil Kumar Wanchoo   +5 more
wiley   +1 more source

The Effect of Cranberry Consumption on C‐Reactive Protein and Interleukin‐6: A Systematic Review and Meta‐Analysis of Randomized Controlled Trials

Food Science &Nutrition, Volume 14, Issue 2, February 2026.
Cranberry and inflammatory markers. ABSTRACT Previous clinical trials examining the effects of cranberry on inflammatory markers have yielded inconsistent results. This study specifically aimed to assess the influence of cranberry consumption on C‐reactive protein (CRP) and Interleukin‐6 in randomized controlled trials (RCTs).
Mohammad Reza Amini, Mahsa Elahikhah, Sajjad Etesamnia, Motahareh Yadegari, Mohammadreza Moradi Baniasadi, Negin Lohrasbi, Gholamreza Askari   +6 more
wiley   +1 more source

MSC Exosomes and Rutin‐Chitosan–Pectin Nanoparticles Synergize to Ameliorate Adjuvant Arthritis via Th1/Th2 Modulation, MMP Suppression, Nrf2 Upregulation, and Antioxidant Boost

Stem Cells International, Volume 2026, Issue 1, 2026.
Background Due to toxicity, high costs, and potential side effects of standard treatments of rheumatoid arthritis (RA) including nonsteroidal anti‐inflammatory drugs (NSAIDs), corticosteroids, and disease‐modifying antirheumatic drugs (DMARDs), natural products and advanced drug delivery systems, such as nanoparticles and mesenchymal stem cell (MSC ...
Karim M. Moftah, Walaa G. Hozayen, Nabil A. Hasona, Hessah M. Al-Muzafar, Kamal A. Amin, Hussah A. Alshwyeh, Khairy M. A. Zoheir, Osama M. Ahmed, Hussein M. El-Husseiny   +8 more
wiley   +1 more source