Results 101 to 110 of about 3,555 (243)

Enhancing antitumour response to proteasome inhibitors with inhibitors of insulin‐degrading enzyme, a new molecular vulnerability in multiple myeloma

British Journal of Pharmacology, EarlyView.
Inhibitors of insulin‐degrading enzyme boost PI cytotoxicity through an increased sensitivity of proteasome to PI inhibitors, induction of ISR, DNA damage and Myc down‐regulation. They overcome PI resistance in vitro and induce tumour regression in vivo.
Laetitia Lesire, Rebecca Deprez‐Poulain, Damien Bosc, Florence Leroux, Valerie Landry, Sarah Ourabah, Morgane Tardy, Clara Maillard, Ronan Gealageas, Julie Dumont, Adrien Herledan, Sandrine Warenghem, Manon Cruette, Celine Lenglart, Alexandre Biela, Catherine Piveteau, Eva De Smedt, Catharina Muylaert, Wenguang Liang, Elvira Garcia De Paco, Elina Alaterre, Sara Ovejero, Nicolas Robert, Fabien Delahaye, Wei‐Jen Tang, Peter van Endert, Elke De Bruyne, Jérôme Moreaux, Benoit Deprez   +28 more
wiley   +1 more source

Scenariji budućnosti – afektivne i kognitivne reakcije ljudi na informacije o budućnosti i tehničkom razvoju

Psychological Topics, 2019
Cilj je istraživanja bio ispitati kognitivne i afektivne reakcije ljudi na informacije o vrlo brzom tehničkom razvoju koji će se, sukladno Mooreovu zakonu o eksponencijalnom razvitku tehnike i predviđanjima stručnjaka za računalne znanosti, u bliskoj ...
Eva Jurković, Dragutin Ivanec
doaj  

Using miniaturized laboratory equipment and DNA barcoding to improve conservation genetics training and identify illegally traded species

Conservation Biology, EarlyView.
Abstract Illegal wildlife trade (IWT) is one of the largest global illegal activities, and it negatively affects biodiversity and sustainable development worldwide. DNA barcoding coupled with high‐throughput sequencing (i.e., metabarcoding) is useful in identifying taxa affected by IWT and has been used routinely for decades.
Maria Joana Ferreira da Silva, Ivo Colmonero‐Costeira, Saidil Lamine Djaló, Tomás Camará, Rui M. Sá, Tania Minhós, Angelika Kiebler, Martin Grethlein, Netta Pikkarainen, Stefan Prost   +9 more
wiley   +1 more source

An Angler‐Friendly AI Pipeline for Self‐Reporting and Automatic Catch Analysis in Recreational Fisheries

Fish and Fisheries, EarlyView.
ABSTRACT Monitoring recreational fisheries is difficult: anglers are widely dispersed, gear and practices vary, and many species are involved, which leads to fragmented and scarce data. To address these issues, we developed an Artificial Intelligence (AI) pipeline that turns angler‐reported photos into standardised records of catch composition and ...
Marco Signaroli, Bernat Morro, Eugenio Cutolo, Ignacio A. Catalán, Inmaculada Riera, Antoni Mira, Clara Mecinas, Antoni M. Grau, Yolanda Gonzalez‐Cid, Josep Alós   +9 more
wiley   +1 more source

Razvoj proizvoda

, 2018
Tema ovog rada je od inovacije do razvoja proizvoda. Radi Globalizacije poduzetnici su prisiljeni stalno raditi na novim idejama i inovacijama kako bi ostali konkurentni na tržištu te kako bi njihovo poduzeće opstalo. Razvojem tehnologije javlja se i više konkurenata pa radi toga poduzetnici moraju stalno razvijat nove ideje kako bi se distancirali od ...
openaire   +1 more source

Moderate increase of MET in hepatocytes protects against cholestatic liver injury by promoting an effective antioxidant response

The FEBS Journal, EarlyView.
Moderate overexpression of wild‐type Met in hepatocytes (Alb‐R26Met mouse model) boosts a strong antioxidant response dependent on the glutathione system while impairing TGF‐β signaling in the liver. This leads to improved liver regeneration and protects against DDC‐induced injury, a model for cholestatic disease sharing features with primary ...
Carlos González‐Corralejo, Juan García‐Sáez, María Figueroa‐Fuentes, Annalisa Addante, Cesáreo Roncero, Nerea Lazcanoiturburu, Beatriz Pacheco, Julián Sanz, Cristina Gato, Eva Fernández‐Calderón, María de la O López, Águeda González‐Rodríguez, Almudena Porras, Flavio Maina, Isabel Fabregat, Blanca Herrera, Aránzazu Sánchez   +16 more
wiley   +1 more source

Utjecaj monetarne unije i uvođenje eura na gospodarske sustave europskih zemalja i Republike Hrvatske

Ekonomski Vjesnik, 2000
Sastanak u Luxemhurgu 1997. godine bio je prekretnica u dotadašnjem razvoju Europske unije. Na sastanku su dogovoreni uvjeti za novo proširenje Europske unije i razrađena treća faza provedbe Europske monetarne unije (EMU).
Ana Vizjak
doaj  

Selective targeting of cortactin tandem repeat acetylation by human lysine deacetylases

The FEBS Journal, EarlyView.
Cortactin function is regulated by acetylation at several lysine residues within its tandem repeat region. Using genetic code expansion to generate cortactin variants containing precisely defined acetylation marks, we show that HDAC6 is the primary enzyme removing these modifications, with SIRT1 and SIRT2 also acting at selected sites but with lower ...
Jan Komarek, Miroslava Vosahlikova, Zsofia Kutil, Zora Novakova, Julia Kudlacova, Ruzena Tuckova, Marat Meleshin, Barbora Havlinova, Pavlina Jaklova, Jana Ptackova, Cordelia Schiene‐Fischer, Mike Schutkowski, Cyril Barinka   +12 more
wiley   +1 more source

Polyesterase activity and thermostability of carboxylesterases from Thermoleophilum album YS‐3

The FEBS Journal, EarlyView.
Three novel α/β‐hydrolases from thermophilic bacterium Thermoleophilum album display carboxylesterase and polyesterase activity. These enzymes hydrolyse PET, PLA and PCL both at high and moderate temperatures. TA21 shows superior activity, efficiently converting MHET to terephthalic acid. Structural features underlying substrate binding highlight their
Tatyana N. Chernikova, Anna N. Khusnutdinova, Hairong Ma, Manuel Ferrer, Olga V. Golyshina, Alexander F. Yakunin, Peter N. Golyshin   +6 more
wiley   +1 more source

Recompression Improves Release Success in Pollack (Pollachius pollachius): A Step Towards Assessing Post Release Mortality in a Recreational Fishery

Fisheries Management and Ecology, EarlyView.
ABSTRACT The recreational fishery for pollack (Pollachius pollachius) in the northeast Atlantic is impacted by the species' high sensitivity to barotrauma. When captured at depth and brought to the surface, gas expansion within the peritoneal cavity can cause a variety of injuries and hinder release.
T. Stamp, R. Mawer, R. Conlon, A. E. Hall, P. Davies, R. Nesbit, D. Uren, T. Morris, S. Sullivan, S. Thomas, B. D. Stewart, H. Rudd, K. Hyder, T. Osmond, S. Reynell, E. V. Sheehan   +15 more
wiley   +1 more source