Results 241 to 250 of about 303,192 (319)

PVR (CD155) epigenetic status mediates immunotherapy response in multiple myeloma. [PDF]

open access: yesLeukemia
Martinez-Verbo L   +23 more
europepmc   +1 more source

Women with PCOS have a later menopausal transition and a lower prevalence of menopausal symptoms at age 46: A population‐based birth cohort study

open access: yesActa Obstetricia et Gynecologica Scandinavica, Volume 105, Issue 5, Page 836-846, May 2026.
Findings from a population‐based cohort study indicate that late peri−/postmenopausal status, as well as menopausal symptoms, were less prevalent in women with PCOS at age 46, supporting the hypothesis of prolonged ovarian function and a delayed menopausal transition with this condition. Created in https://BioRender.com.
Johanna Lavi   +6 more
wiley   +1 more source

Citrate‐Dependent Activation of Acetyl CoA Carboxylase Promotes Renal Lipid Accumulation in a Rat Model of Chronic Kidney Disease

open access: yesActa Physiologica, Volume 242, Issue 5, May 2026.
ABSTRACT Background Abnormal accumulation of lipids within the kidney contributes to the progression of chronic kidney disease, but the underlying metabolic mechanisms remain unclear. Citrate is a central metabolite in cellular energy regulation and is frequently elevated in advanced kidney disease, yet its impact on renal lipid metabolism has not been
Marta Sanz‐Gómez   +8 more
wiley   +1 more source

14‐3‐3σ up‐regulation in the temporal cortex associates with tau pathology and reactive astroglia in Lewy body disorders

open access: yesBrain Pathology, Volume 36, Issue 3, May 2026.
14‐3‐3 protein homeostasis is disrupted in Lewy body pathology, showing a diminution of six isotypes and overexpression of stratifin. The latter was associated with stratifin colocalization with tau pathology and reactive astrocytes. Platelets, as a peripheral biomarker source, mirrored inversely cortical 14‐3‐3 gene expression patterns in dementia ...
Laura Marsal‐García   +13 more
wiley   +1 more source

A blood-based epigenetic clock for intrinsic capacity predicts mortality and is associated with clinical, immunological and lifestyle factors. [PDF]

open access: yesNat Aging
Fuentealba M   +7 more
europepmc   +1 more source

Divergence in μ and δ opioid receptor pharmacology in neurons and antinociceptive efficacy in neuropathic pain: Insights from MP135 and CYM51010

open access: yesBritish Journal of Pharmacology, Volume 183, Issue 10, Page 2307-2323, May 2026.
Background and purpose Opioids targeting the μ opioid receptor remain largely ineffective in neuropathic pain conditions, emphasizing the need for novel therapeutic strategies. MP135 was reported to reduce thermal nociception in naive animals by activating μ‐δ opioid receptor heteromers.
Perrine Inquimbert   +13 more
wiley   +1 more source

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