Results 31 to 40 of about 45,275 (308)

Establishment of hepatitis C virus RNA-replicating cell lines possessing ribavirin-resistant phenotype.

PLoS ONE, 2015
BackgroundRibavirin (RBV) is a potential partner of interferon-based therapy and recently approved therapy using direct acting antivirals for patients with chronic hepatitis C.
Shinya Satoh, Kyoko Mori, Youki Ueda, Hiroe Sejima, Hiromichi Dansako, Masanori Ikeda, Nobuyuki Kato   +6 more
doaj   +1 more source

Multicenter Experience using Ledipasvir/Sofosbuvir ± RBV to Treat HCV GT 1 Relapsers after Simeprevir and Sofosbuvir Treatment

Annals of Hepatology, 2018
Introduction and aim. Approximately 10%-15% of patients with hepatitis C genotype 1 (HCV GT1) experience virological relapse after all-oral antiviral regimen using simeprevir (SMV) and sofosbuvir (SOF).
Bashar Aqel, Michael Leise, Hugo E. Vargas, Kymberly D. Watt, Andrew P. Keaveny, Nan Zhang, Surakit Pungpapong   +6 more
doaj   +1 more source

The resource-based view: a tool of key competency for competitive advantage [PDF]

Problems and Perspectives in Management, 2019
The increasing turmoil in the external organizational setting or business environment has focused attention on capabilities and resources as the primary source of competitive advantage.
Akwesi Assensoh-Kodua
doaj   +1 more source

Industrial districts as organizational environments: resources, networks and structures [PDF]

, 2006
The paper combines economic and sociological perspectives on organizations in order to gain a better understanding of the forces shaping the structures of industrial districts (IDs) and the organizations of which they are constituted.
Popp, A., Toms, S., Wilson, J.
core   +1 more source

Interferon convencional versus interferon peguilado associados à ribavirina no tratamento de pacientes coinfectados pelo vírus da hepatite C (genótipo 1) e da imunodeficiência humana Alpha-interferon versus peg-interferon associated to ribavirin in the treatment of genotype 1 hepatitis C virus and human imunodeficiency virus coinfected patients

Arquivos de Gastroenterologia, 2009
CONTEXTO: Tem sido sugerido que os pacientes coinfectados por vírus da hepatite C e da imunodeficiência humana (VHC/HIV) devam ser tratados com interferon peguilado associado à ribavirina (PEG+RBV) porque as taxas de resposta virológica sustentada seriam
Paulo Roberto Lerias de Almeida, Cristiane Valle Tovo, Juliana Oliveira Rigo, Pauline Zanin, Alexandro Vasquen Alves, Angelo Alves de Mattos   +5 more
doaj   +1 more source

Resources supporting entrepreneurial orientation in multigenerational family firms [PDF]

, 2010
We examine entrepreneurship in multigenerational family firms. Specifically, we employ theoretical lenses drawn from both entrepreneurship (entrepreneurial orientation) and strategy (resource-based view) to develop an integrated model of ...
Irava, Wayne, Moores, Ken
core   +1 more source

HCV treatment for prevention among people who inject drugs: Modeling treatment scale-up in the age of direct-acting antivirals. [PDF]

, 2013
UNLABELLED: Substantial reductions in hepatitis C virus (HCV) prevalence among people who inject drugs (PWID) cannot be achieved by harm reduction interventions such as needle exchange and opiate substitution therapy (OST) alone. Current HCV treatment is
Aitken, Allen, Berg, Burns, Cohen, Cohen, Cornish, Dahari, Dimova, Dore, Gane, Grebely, Grebely, Hagan, Hallinan, Harris, Health Protection Scotland and the University of the West of Scotland, Hellard, Hellard, Hickman, Innes, Iverson, Iverson, Jacobson, Kemp, Kim, Kimber, Kirwan, Lindenburg, Lindenburg, Liu, Liu, Ly, Maher, Martin, Martin, Martin, Mathers, McCaw, McInnes, Mehta, Micallef, Mondelli, Nelson, Nosyk, O'Keefe, Poordad, Poordad, Quinn, Shepard, Stoove, Sweeting, Turner, Vickerman, Vickerman, Wood, Zeiler   +56 more
core   +5 more sources

Negative Predictive Value of IL28B, SLC28A2, and CYP27B1 SNPs and Low RBV Plasma Exposure for Therapeutic Response to PEG/IFN-RBV Treatment

Therapeutic Drug Monitoring, 2012
The response rate to treatment of chronic hepatitis C virus-genotype 1 and 4 infections was recently found to be strongly influenced by many polymorphisms. The aim of our study was to carry out an integrated analysis of the effects of polymorphisms and ribavirin (RBV) plasma exposure on outcome.The retrospective analysis included 174 patients.
Dʼavolio A, CIANCIO, Alessia, SICCARDI, MARCO, SMEDILE, Antonina, SIMIELE, MARCO, CUSATO, JESSICA, BAIETTO, LORENA, Marucco DA, Cariti G, CALCAGNO, Andrea, GONZALEZ DE REQUENA, Daniel, SCIANDRA, Mauro, Troshina G, CAVIGLIA, GIAN PAOLO, BONORA, Stefano, RIZZETTO, Mario, DI PERRI, Giovanni   +16 more
openaire   +3 more sources

Interferon and ribavirin combination treatment synergistically inhibit HCV internal ribosome entry site mediated translation at the level of polyribosome formation. [PDF]

PLoS ONE, 2013
Although chronic hepatitis C virus (HCV) infection has been treated with the combination of interferon alpha (IFN-α) and ribavirin (RBV) for over a decade, the mechanism of antiviral synergy is not well understood.
Rajesh Panigrahi, Sidhartha Hazari, Sruti Chandra, Partha K Chandra, Sibnarayan Datta, Ramazan Kurt, Craig E Cameron, Zhuhui Huang, Haitao Zhang, Robert F Garry, Luis A Balart, Srikanta Dash   +11 more
doaj   +1 more source

Disorder‐Driven Fast Na+ Transport: From Crystalline to Amorphous Networks in the Mixed‐Anion NaTaOxCl6−2x Oxychlorides

Advanced Energy Materials, EarlyView.
Oxygen substitution in NaTaOxCl6‐2x drives structural evolution from isolated [TaCl6]– octahedra, through oxygen‐bridged [Ta2OCl10]2– dimers, toward extended trans‐[TaO2Cl4]3– chain‐like arrangements. At intermediate compositions, zero‐dimensional corner‐sharing motifs are proposed to create a flexible, disordered framework that peaks ionic ...
Justin Leifeld, Abigail C. Parsons, Alexandra Morscher, Xabier Martinez de Irujo‐Labalde, Marvin A. Kraft, Oskar G. Soulas, Bibek Samanta, Wiebke Zielasko, Neelam Yadav, Kyra Strotmann, Niina Jalarvo, Bruno V. M. Rodrigues, Adam Slabon, Philipp Adelhelm, Michael Ryan Hansen, David O. Scanlon, Wolfgang G. Zeier, Alexander G. Squires   +17 more
wiley   +1 more source