Results 11 to 20 of about 45,307 (50)

In Humanized Sickle Cell Mice, Imatinib Protects Against Sickle Cell–Related Injury

HemaSphere, 2023
Drug repurposing is a valuable strategy for rare diseases. Sickle cell disease (SCD) is a rare hereditary hemolytic anemia accompanied by acute and chronic painful episodes, most often in the context of vaso-occlusive crisis (VOC).
Enrica Federti, Alessandro Matte, Antonio Recchiuti, Francesca Garello, Alessandra Ghigo, Wassim El Nemer, Enzo Terreno, Angela Amoresano, Domenico Mattoscio, Franco Turrini, Christophe Lebouef, Anne Janin, Antonella Pantaleo, Roberta Russo, Mickael Marin, Iana Iatcencko, Veronica Riccardi, Angela Siciliano, Achille Iolascon, Carlo Brugnara, Lucia De Franceschi   +20 more
doaj   +1 more source

From Genotype to Phenotype: How Enhancers Control Gene Expression and Cell Identity in Hematopoiesis

HemaSphere, 2023
Blood comprises a wide array of specialized cells, all of which share the same genetic information and ultimately derive from the same precursor, the hematopoietic stem cell (HSC).
Roger Mulet-Lazaro, Ruud Delwel
doaj   +1 more source

A Question of Frame: The Role of the Bone Marrow Stromal Niche in Myeloid Malignancies

HemaSphere, 2023
Until a few years ago, the onset of acute myeloid leukemia (AML) was entirely ascribed to genetic lesions in hematopoietic stem cells. These mutations generate leukemic stem cells, which are known to be the main ones responsible for chemoresistance and ...
Chiara Tomasoni, Alice Pievani, Benedetta Rambaldi, Andrea Biondi, Marta Serafini   +4 more
doaj   +1 more source

Impact of SARS-CoV-2 infection on patients with hematological malignancies: a retrospective study

Hematology, 2023
Objectives This study aimed to evaluate the characteristics of patients with hematological malignancies (HM) and SARS-CoV-2 infection and analyze the risk factors of their severity and mortality.Methods A retrospective study including inpatients ...
Huihan Zhao, Yu He, Zhongqing Li, Yanlu Huang, Yanping Ying, Zhaoquan Huang   +5 more
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Hyperviscosity Syndrome Induced Bilateral Visual and Auditory Impairment in Therapy Resistant Waldenström Macroglobulinemia with MYD88 and CXCR4 Mutations

Journal of Blood Medicine, 2023
Marie M Plante,1 ErinMarie O Kimbrough,2 Amit K Agarwal,3 Liuyan Jiang,4 Kirk Bourgeois,4 Greta C Stamper,5 Michael W Stewart,6 Han W Tun2 1Department of Internal Medicine, Mayo Clinic, Jacksonville, FL, USA; 2Division of Hematology and Oncology, Mayo ...
Plante MM, Kimbrough EO, Agarwal AK, Jiang L, Bourgeois K, Stamper GC, Stewart MW, Tun HW   +7 more
doaj  

Translation and cultural adaptation of the Health Utilities Preschool to Brazilian Portuguese

Hematology, Transfusion and Cell Therapy
Introduction: Health research is particularly important in low- and middle-income countries (LMICs), where improvements must be achieved with limited resources, and where the great majority of the world's population, especially children, live ...
Karina Viani, Bruno Fernandes Bernardes, Marilia Nasz Veiga, Renato Canton Viani, Tomas Marzagão Barbuto, Ronald D. Barr   +5 more
doaj   +1 more source

High PD-L1 expression is associated with unfavorable clinical features in myelodysplastic neoplasms

Hematology, Transfusion and Cell Therapy
Abstatct: Introduction: Immune checkpoints are regulators of the immune system response that allow self-tolerance. Molecules such as Programmed Cell Death Protein 1 (PD-1) and its Ligand (PD-L1) participate in the immune checkpoint by signaling co ...
Leticia Rodrigues Sampaio, Mateus de Aguiar Viana, Vanessa Silva de Oliveira, Bruna Vitoriano Ferreira, Mayara Magna Lima Melo, Roberta Taiane Germano de Oliveira, Daniela de Paula Borges, Silvia Maria Meira Magalhãesa, Ronald F. Pinheiro   +8 more
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Factores de riesgo cardiovascular y su relación con la progresión de la enfermedad venosa crónica

Revista Mexicana de Angiología
Antecedentes: La progresión de la enfermedad venosa crónica (EVC) suele estar ligada a factores de riesgo que son motivo de investigación aun sin asociación clara.
Leopoldo E. Padilla-Hernández, Omar A. Hernández-Hurtado, Carlos Flores-Ramírez, Joaquín M. Santoscoy-Ibarra, Luis B. Enríquez-Sánchez, Raúl A. Hinojos-Flotte, Dalia G. Delgado-Ortega, Yarazi M. Carrasco-Arredondo   +7 more
doaj   +1 more source

Elevated Transferrin at High Altitude: Trick or Treat?

HemaSphere, 2023
Francesca Vinchi
doaj   +1 more source

Tumor lysis syndrome in hematological inpatients, experience from a university hospital in Brazil: A retrospective cohort study

Hematology, Transfusion and Cell Therapy
Introduction: The tumor lysis syndrome is a medical emergency. Its presentation can be spontaneous or secondary, as a consequence of the established treatment. The diagnosis and treatment of the tumor lysis syndrome (TLS) has become a crucial goal to the
Ebellins Tabares Calvache, Allison Dessiret Tabares Calvache, Cristiane Seganfredo Weber   +2 more
doaj   +1 more source