Results 21 to 30 of about 67,740 (99)

miR-665 inhibits epithelial-to-mesenchymal transition in bladder cancer via the SMAD3/SNAIL axis

Cell Cycle, 2021
Emerging research indicates that miRNAs can regulate cancer progression by influencing molecular pathways. Here, we studied miR-665, part of the DLK1-DIO3 miRNA cluster, which is downregulated by upstream methylation in bladder cancer.
Weiyu Wang, Yufan Ying, Haiyun Xie, Jiangfeng Li, Xueyou Ma, Liujia He, Mingjie Xu, Shiming Chen, Haixiang Shen, Xiangyi Zheng, Ben Liu, Xiao Wang, Liping Xie   +12 more
semanticscholar   +1 more source

MiR-665 Regulates Vascular Smooth Muscle Cell Senescence by Interacting With LncRNA GAS5/SDC1

Frontiers in Cell and Developmental Biology, 2021
Background: Vascular aging is considered a special risk factor for cardiovascular diseases, and vascular smooth muscle cells (VSMCs) play a major role in aging-related vascular remodeling and in the pathological process of atherosclerosis.
Tianbin Chen, Qingyang Liang, Jialin Xu, Yanan Zhang, Yi Zhang, Liping Mo, Li Zhang   +6 more
semanticscholar   +1 more source

Causal impact of human blood metabolites and metabolic pathways on serum uric acid and gout: a mendelian randomization study

Frontiers in Endocrinology
ObjectiveHyperuricaemia and gout are common metabolic disorders. However, the causal relationships between blood metabolites and serum urate levels, as well as gout, remain unclear.
Yan Zhong, ChengAn Yang, BingHua Zhang, YingWen Chen, WenJun Cai, GuoChen Wang, ChangWei Zhao, WenHai Zhao   +7 more
doaj   +1 more source

MicroRNA-665 facilitates cell proliferation and represses apoptosis through modulating Wnt5a/β-Catenin and Caspase-3 signaling pathways by targeting TRIM8 in LUSC

Cancer Cell International, 2021
Background MicroRNAs (miRNAs) are involved in the oncogenesis, development and transformation of lung squamous cell carcinoma (LUSC). miR-665 is clinically significant and acts as a pivotal function in some cancers.
Tian-jun Chen, Qi-Fan Zheng, F. Gao, Tian Yang, H. Ren, Yang Li, Ming-Wei Chen   +6 more
semanticscholar   +1 more source

Development and Validation of a Measure for Seeking Health Information in the Diabetes Online Community: Mixed Methods Study

JMIR Diabetes
BackgroundIndividuals with chronic diseases often search for health information online. The Diabetes Online Community (DOC) is an active community with members who exchange health information; however, few studies have examined ...
Allyson S Hughes, Sarah Beach, Spruhaa Vasistha, Nazanin Heydarian, Osvaldo Morera   +4 more
doaj   +1 more source

METTL3-mediated pre-miR-665/DLX3 m6A methylation facilitates the committed differentiation of stem cells from apical papilla

Experimental and Molecular Medicine
Methyltransferase-like 3 (METTL3) is a crucial element of N6-methyladenosine (m6A) modifications and has been extensively studied for its involvement in diverse biological and pathological processes.
Tingjie Gu, Rong Guo, Yuxin Fang, Ya Xiao, Luyao Chen, Na Li, Xingyun Kelesy Ge, Yijia Shi, Jintao Wu, Ming Yan, Jinhua Yu, Zehan Li   +11 more
semanticscholar   +1 more source

LncRNA LIMT (LINC01089) contributes to sorafenib chemoresistance via regulation of miR-665 and epithelial to mesenchymal transition in hepatocellular carcinoma cells

Acta Biochimica et Biophysica Sinica, 2021
Hepatocellular carcinoma (HCC) is one of the most malignant tumors worldwide and HCC patients often develop drug resisitene. Long non-coding RNAs (LncRNAs) are closely related to cell cycle, growth, development, differentiation, and apoptosis. Abnormally
Jing Sun, Xiao-xiao Zheng, Bao-Yan Wang, Yingjian Cai, Li Zheng, Li-qiang Hu, Xuemei Lu, Shangzhi Xie, Xin Zhang, Hao Liu, Longyun Ye   +10 more
semanticscholar   +1 more source

Eight-year nationwide study of the bidirectional association between type 2 diabetes and depression in nearly 8 million German outpatients

BMJ Open Diabetes Research & Care
Introduction Research linking type 2 diabetes and depression mostly relied on hospital-based diagnoses or prescription data, overlooking many outpatient diagnoses.
Christopher Rohde, Christian Otte, Woo Ri Chae, Ole Köhler-Forsberg, Claudia Kohring, Jakob Holstiege   +5 more
doaj   +1 more source

CircRNA_0044556 affects the sensitivity of triple-negative breast cancer cells to paclitaxel by regulating miR-665

Journal of chemotherapy
CircRNAs have been implicated in the development of resistance in triple-negative breast cancer (TNBC). However, the association between circRNA_0044556 and paclitaxel (PTX) resistance in TNBC is still limited. Therefore, the purpose of this study was to
Jing-Jing Chen, Peng Shi, Zhi-Chao Cui, Nan Jiang, Jie Ma   +4 more
semanticscholar   +1 more source

LncRNA DCST1-AS1 Promotes Endometrial Cancer Progression by Modulating the MiR-665/HOXB5 and MiR-873-5p/CADM1 Pathways

Frontiers in Oncology, 2021
Dysregulation of long noncoding RNA (lncRNA) is implicated in the initiation and progression of various tumors, including endometrial cancer (EC). However, the mechanism of lncRNAs in EC tumorigenesis and progression remains largely unexplored.
Jie Wang, Pingping Shi, Hua Teng, L. Lu, Hailong Guo, Xiuqin Wang   +5 more
semanticscholar   +1 more source