Results 31 to 40 of about 67,740 (99)

Early increase in HbA1c trajectory predicts development of severe microangiopathy in patients with type 1 diabetes: the VISS study

BMJ Open Diabetes Research & Care
Introduction To study the HbA1c trajectory from the time of diagnosis to examine if patients at the greatest risk for severe microangiopathy can be identified early allowing clinicians to intervene as soon as possible to avoid complications.Research ...
Johnny Ludvigsson, Maria Nordwall, Hans J Arnqvist   +2 more
doaj   +1 more source

Inhibition of miR-665-3p Enhances Autophagy and Alleviates Inflammation in Fusarium solani-Induced Keratitis

Investigative Ophthalmology and Visual Science, 2021
Purpose Accumulated evidence has shown that microRNAs (miRNAs) are closely related with the regulation of autophagy, which plays vital roles in fungal keratitis (FK). Microarray data showed elevated expression of miR-665-3p in mouse corneal tissues after
Qunqin Guo, Yi Lin, Jianzhang Hu
semanticscholar   +1 more source

Analysis of single nucleotide polymorphisms of the metabotropic glutamate receptors in a transgender population

Frontiers in Endocrinology
IntroductionGender incongruence (GI) is characterized by a marked incongruence between an individual’s experienced/expressed gender and the assigned sex at birth.
Rosa Fernández, Rosa Fernández, Karla Ramírez, Karla Ramírez, Roberto Lorente-Bermúdez, Esther Gómez-Gil, Mireia Mora, Antonio Guillamon, Eduardo Pásaro, Eduardo Pásaro   +9 more
doaj   +1 more source

Long non-coding RNA NHEG1/hsa-miR-665/HMGB1 axis is involved in the regulation of neuroblastoma progression

Bioengineered, 2021
Long non-coding (lncRNA) neuroblastoma highly expressed 1 (NHEG1) has been reorganized as a prognostic factor in neuroblastoma (NB), but the molecular mechanisms in the suppression of neuroblastoma remain to be elucidated.
Yuqing Zhang, Yuping Hu, Aihong Pan, Lei He, Jin Wang, Fan Zhou, Yongbo Lei, Yuanyuan Wang   +7 more
semanticscholar   +1 more source

Restricted linear association between night sleep duration and diabetes risk in middle-aged and older adults: a 7-year follow-up analysis from the China health and retirement longitudinal study

Frontiers in Endocrinology
BackgroundA rapid increase in the prevalence of diabetes is an urgent public health concern among older adults, especially in developing countries such as China.
Mutong Chen, Mutong Chen, Baizhi Li, Guanhua Fan, Guanhua Fan, Yuqiu Zhou   +5 more
doaj   +1 more source

Bta-miR-665 improves bovine blastocyst development through its influence on microtubule dynamics and apoptosis

Frontiers in Genetics
Extracellular vesicles (EVs) contain microRNAs (miRNAs), which are important regulators of embryonic development. Nevertheless, little is known about the precise molecular processes controlling blastocyst development and quality.
X. Guan, Yuan Fan, R. Six, C. Benedetti, Annelies Raes, A. Fernandez Montoro, Xiaole Cui, Nima Azari Dolatabad, A. Van Soom, K. Pavani, L. Peelman   +10 more
semanticscholar   +1 more source

The integrated incretin effect is reduced by both glucose intolerance and obesity in Japanese subjects

Frontiers in Endocrinology
IntroductionIncretin-based drugs are extensively utilized in the treatment of type 2 diabetes (T2D), with remarkable clinical efficacy. These drugs were developed based on findings that the incretin effect is reduced in T2D.
Akihiro Hamasaki, Akihiro Hamasaki, Norio Harada, Atsushi Muraoka, Shunsuke Yamane, Erina Joo, Kazuyo Suzuki, Nobuya Inagaki   +7 more
doaj   +1 more source

miR-665-Mediated Regulation of AHCYL2 and BVES Genes in Recurrent Implantation Failure

Genes
The primary goal of this investigation was to identify mRNA targets affected by dysregulated miRNAs in RIF. This was accomplished by comprehensively analyzing mRNA and miRNA expression profiles in two groups: female subjects with normal reproductive ...
S. Cho, Young Myeong Kim, H. An, Ji Hyang Kim, N. Kim   +4 more
semanticscholar   +1 more source

Adrenalectomy for primary aldosteronism and its related surgical characteristics

Frontiers in Endocrinology
Primary aldosteronism (PA) is a common cause of secondary hypertension. Adrenalectomy is an effective treatment for unilateral PA, particularly aldosterone-producing adenoma (APA), resulting in improvements in biochemical parameters and blood pressure in
Hao Xiang, Tingting Zhang, Wei Song, Deyong Yang, Deyong Yang, Xinqing Zhu   +5 more
doaj   +1 more source

Association between oxidative balance score and serum uric acid and hyperuricemia: a population-based study from the NHANES (2011–2018)

Frontiers in Endocrinology
BackgroundOxidative Balance Score (OBS) is a novel indicator of the overall antioxidant/oxidant balance, providing a comprehensive reflection of the body’s overall oxidative stress status, with higher OBS suggesting more substantial antioxidant exposures.
Yuhao Yang, Zengxiang Wu, Zhenmei An, Shuangqing Li   +3 more
doaj   +1 more source