Results 51 to 60 of about 67,740 (99)

Glucose metabolism partially regulates β‐cell function through epigenomic changes

Journal of Diabetes Investigation
The β‐cell relies predominantly on glucose utilization to generate adenosine triphosphate, which is crucial for both cell viability and insulin secretion.
Yong Kyung Kim, Kyu Chang Won, Lori Sussel   +2 more
doaj   +1 more source

Testicular differentiation in 46,XX DSD: an overview of genetic causes

Frontiers in Endocrinology
In mammals, the development of male or female gonads from fetal bipotential gonads depends on intricate genetic networks. Changes in dosage or temporal expression of sex-determining genes can lead to differences of gonadal development.
Maria Tereza Martins Ferrari, Elinaelma Suelane do Nascimento Silva, Mirian Yumie Nishi, Rafael Loch Batista, Berenice Bilharinho Mendonca, Berenice Bilharinho Mendonca, Sorahia Domenice   +6 more
doaj   +1 more source

Performance of different machine learning algorithms in identifying undiagnosed diabetes based on nonlaboratory parameters and the influence of muscle strength: A cross‐sectional study

Journal of Diabetes Investigation
Aims/Introduction Machine learning algorithms based on the artificial neural network (ANN), support vector machine, naive Bayesian or logistic regression model are commonly used to identify diabetes.
Ying Xu, Shanhu Qiu, Jinli Ye, Dan Chen, Donglei Wang, Xiaoying Zhou, Zilin Sun   +6 more
doaj   +1 more source

Association of genetically determined chronotype with circulating testosterone: a Mendelian randomization study

Frontiers in Endocrinology
Low testosterone levels in men have been linked to decreased physical and mental function, as well as a reduced quality of life. Previous prospective observational studies have suggested an association between testosterone and sleep traits, but the ...
Tomohiro Ichikawa, Takuro Kobayashi, Tsuyoshi Hachiya, Yoshihiro Ikehata, Shuji Isotani, Hisamitsu Ide, Shigeo Horie, Shigeo Horie   +7 more
doaj   +1 more source

Fulminant type 1 diabetes, an underrecognized and unique subtype of type 1 diabetes: A case series from Singapore

Journal of Diabetes Investigation
Fulminant type 1 diabetes (FT1D) is a unique subtype of type 1 diabetes, characterized by acute absolute insulin deficiency, severe ketosis, and increased risk of hypoglycemia, glycemic variability and microvascular complications.
Sarah Ying Tse Tan, Suresh Rama Chandran, Jielin Yew, Andy Jun‐Wei Wong, Daphne Su‐Lyn Gardner   +4 more
doaj   +1 more source

Plasma angiotensin-converting enzyme 2 (ACE2) is a marker for renal outcome of diabetic kidney disease (DKD) (U-CARE study 3)

BMJ Open Diabetes Research & Care
Introduction ACE cleaves angiotensin I (Ang I) to angiotensin II (Ang II) inducing vasoconstriction via Ang II type 1 (AT1) receptor, while ACE2 cleaves Ang II to Ang (1–7) causing vasodilatation by acting on the Mas receptor. In diabetic kidney disease (
Satoshi Yamaguchi, Koki Mise, Jun Wada, Kenichi Shikata, Takashi Matsuoka, Haruhito A Uchida, Asami Ueno, Yasuhiro Onishi, Ayaka Kanno, Ichiro Nojima, Chigusa Higuchi, Satoshi Miyamoto, Atsuko Nakatsuka, Jun Eguchi, Kazuyuki Hida, Akihiro Katayama, Mayu Watanabe, Tatsuaki Nakato, Atsuhito Tone, Sanae Teshigawara, Shinji Kamei, Kazutoshi Murakami, Ikki Shimizu, Katsuhito Miyashita, Shinichiro Ando, Tomokazu Nunoue   +25 more
doaj   +1 more source

LEF1 mediates osteoarthritis progression through circRNF121/miR-665/MYD88 axis via NF-кB signaling pathway

Cell Death and Disease, 2020
Osteoarthritis (OA) is a joint disease that causes great pain to patients and imposes a tremendous burden on the world’s medical resources. Regulatory noncoding RNAs, including circular RNAs (circRNAs) and microRNAs (miRNAs), play an important role in OA
Tianfu Wang, Zhiyu Hao, Changcheng Liu, Lebin Yuan, Li Li, Menghong Yin, Qing Li, Zhiming Qi, Zi Wang   +8 more
semanticscholar   +1 more source

Type 2 diabetes mellitus related sarcopenia: a type of muscle loss distinct from sarcopenia and disuse muscle atrophy

Frontiers in Endocrinology
Muscle loss is a significant health concern, particularly with the increasing trend of population aging, and sarcopenia has emerged as a common pathological process of muscle loss in the elderly.
Zhenchao Liu, Yunliang Guo, Chongwen Zheng   +2 more
doaj   +1 more source

Relationship between the longitudinal trajectory of the triglyceride-glucose index and the development of CKD: an 8-year retrospective longitudinal cohort study

Frontiers in Endocrinology
BackgroundThe triglyceride-glucose (TyG) index, a simple surrogate marker of insulin resistance, is significantly associated with chronic kidney disease (CKD).
Qinchuan Hou, Qinchuan Hou, Huiwang Zhang, Huiwang Zhang, Rui Zhang, Rui Zhang, Binghong Li, Binghong Li, Lei Li, Lei Li, Dongyu Li, Dongyu Li, Xian Wang, Yuping Liu, Zhengwei Wan, Junlin Zhang, Ping Shuai, Ping Shuai, Ping Shuai   +18 more
doaj   +1 more source

Is gestational diabetes mellitus in lean women a distinct entity warranting a modified management approach?

Frontiers in Clinical Diabetes and Healthcare
During pregnancy, insulin resistance and impaired insulin secretion may lead to the development of Gestational Diabetes Mellitus (GDM). Although a higher Body Mass Index (BMI) is often cited as a risk factor for the development of GDM, lean pregnant ...
Pradnyashree Wadivkar, Meredith Hawkins
doaj   +1 more source