Results 51 to 60 of about 65,509 (99)

LncRNA DCST1-AS1 Promotes Endometrial Cancer Progression by Modulating the MiR-665/HOXB5 and MiR-873-5p/CADM1 Pathways

Frontiers in Oncology, 2021
Dysregulation of long noncoding RNA (lncRNA) is implicated in the initiation and progression of various tumors, including endometrial cancer (EC). However, the mechanism of lncRNAs in EC tumorigenesis and progression remains largely unexplored.
Jie Wang, Pingping Shi, Hua Teng, L. Lu, Hailong Guo, Xiuqin Wang   +5 more
semanticscholar   +1 more source

Higher Prevalence of “Low T3 Syndrome” in Patients With Chronic Fatigue Syndrome: A Case–Control Study

Frontiers in Endocrinology, 2018
Chronic fatigue syndrome (CFS) is a heterogeneous disease with unknown cause(s). CFS symptoms resemble a hypothyroid state, possibly secondary to chronic (low-grade) (metabolic) inflammation. We studied 98 CFS patients (21–69 years, 21 males) and 99 age-
Begoña Ruiz-Núñez, Begoña Ruiz-Núñez, Rabab Tarasse, Emar F. Vogelaar, D. A. Janneke Dijck-Brouwer, Frits A. J. Muskiet   +5 more
doaj   +1 more source

Glucagon receptor antagonist upregulates circulating GLP-1 level by promoting intestinal L-cell proliferation and GLP-1 production in type 2 diabetes

BMJ Open Diabetes Research & Care, 2020
ObjectiveGlucagon receptor (GCGR) blockage improves glycemic control and increases circulating glucagon-like peptide-1 (GLP-1) level in diabetic animals and humans.
Shan Lang, Liangbiao Gu, Xiaona Cui, Tianjiao Wei, Junling Liu, Yunyi Le, Rui Wei, Tianpei Hong   +7 more
doaj   +1 more source

Long non-coding RNA NHEG1/hsa-miR-665/HMGB1 axis is involved in the regulation of neuroblastoma progression

Bioengineered, 2021
Long non-coding (lncRNA) neuroblastoma highly expressed 1 (NHEG1) has been reorganized as a prognostic factor in neuroblastoma (NB), but the molecular mechanisms in the suppression of neuroblastoma remain to be elucidated.
Yuqing Zhang, Yuping Hu, Aihong Pan, Lei He, Jin Wang, Fan Zhou, Yongbo Lei, Yuanyuan Wang   +7 more
semanticscholar   +1 more source

Functional Characterization of Paralogous Gonadotropin-Releasing Hormone-Type and Corazonin-Type Neuropeptides in an Echinoderm

Frontiers in Endocrinology, 2017
Homologs of the vertebrate neuropeptide gonadotropin-releasing hormone (GnRH) have been identified in invertebrates, including the insect neuropeptide corazonin (CRZ).
Shi Tian, Michaela Egertová, Maurice R. Elphick   +2 more
doaj   +1 more source

Proinsulin-specific T regulatory cells may control immune responses in type 1 diabetes: implications for adoptive therapy

BMJ Open Diabetes Research & Care, 2020
ObjectiveHere we looked for possible mechanisms regulating the progression of type 1 diabetes mellitus (T1DM). In this disease, autoaggressive T cells (T conventional cells, Tconvs) not properly controlled by T regulatory cells (Tregs) destroy pancreatic
Mateusz Gliwiński, Dorota Iwaszkiewicz-Grześ, Anna Wołoszyn-Durkiewicz, Monika Tarnowska, Magdalena Żalińska, Matylda Hennig, Hanna Zielińska, Anna Dukat-Mazurek, Joanna Zielkowska-Dębska, Maciej Zieliński, Anna Jaźwińska-Curyłło, Radosław Owczuk, Przemysława Jarosz-Chobot, Artur Bossowski, Agnieszka Szadkowska, Natalia Marek-Trzonkowska, Grażyna Moszkowska, Janusz Siebert, Małgorzata Myśliwiec, Piotr Trzonkowski   +19 more
doaj   +1 more source

NAFLD in type 1 diabetes: overrated or underappreciated?

Therapeutic Advances in Endocrinology and Metabolism, 2021
Nonalcoholic fatty liver disease (NAFLD) is the most common chronic liver disease in western countries, affecting 25–30% of the general population and up to 65% in those with obesity and/or type 2 diabetes.
Jonathan Mertens, Luc F. Van Gaal, Sven M. Francque, Christophe De Block   +3 more
doaj   +1 more source

METTL3-mediated pre-miR-665/DLX3 m6A methylation facilitates the committed differentiation of stem cells from apical papilla

Experimental and Molecular Medicine
Methyltransferase-like 3 (METTL3) is a crucial element of N6-methyladenosine (m6A) modifications and has been extensively studied for its involvement in diverse biological and pathological processes.
Tingjie Gu, Rong Guo, Yuxin Fang, Ya Xiao, Luyao Chen, Na Li, Xingyun Kelesy Ge, Yijia Shi, Jintao Wu, Ming Yan, Jinhua Yu, Zehan Li   +11 more
semanticscholar   +1 more source

Inhibition of miR-665-3p Enhances Autophagy and Alleviates Inflammation in Fusarium solani-Induced Keratitis

Investigative Ophthalmology and Visual Science, 2021
Purpose Accumulated evidence has shown that microRNAs (miRNAs) are closely related with the regulation of autophagy, which plays vital roles in fungal keratitis (FK). Microarray data showed elevated expression of miR-665-3p in mouse corneal tissues after
Qunqin Guo, Yi Lin, Jianzhang Hu
semanticscholar   +1 more source

Impact of type 2 diabetes on postoperative outcome after hip fracture: nationwide population-based study in Taiwan

BMJ Open Diabetes Research & Care, 2020
SummaryThe impact of diabetes mellitus (DM) on hip fracture (HFx) is still controversial. We used nationwide population-based data in Taiwan to observe postoperative outcomes of HFx in patients with type 2 diabetes mellitus (T2DM) and found that the ...
Tien-Ching Lee, Yu-Li Lee, Jian-Chih Chen, Chung-Hwan Chen, Pei-Shan Ho   +4 more
doaj   +1 more source