Results 221 to 230 of about 435,551 (310)

Photooxidation of 18‐Carbon Polyunsaturated Fatty Acids to Prepare Mono‐Hydroxylated Octadecanoids

open access: yesLipids, EarlyView.
We developed a fast and simple one‐step synthetic strategy to produce mono‐hydroxylated metabolites based on the photosensitized oxidation of 18‐carbon polyunsaturated fatty acids (PUFAs). This approach could likely be extended to other PUFAs, suggesting that photosensitized oxidation could be employed to rapidly prepare hydroperoxides from multiple ...
Johanna Revol‐Cavalier   +2 more
wiley   +1 more source

Polyglycerol‐Based Lipids: A Next‐Generation Alternative to PEG in Lipid Nanoparticles for Advanced Drug Delivery Systems

open access: yesMacromolecular Rapid Communications, EarlyView.
Linear polyglycerol is proposed as a PEG‐alternative in mRNA‐loaded lipid nanoparticles to limit activation of anti‐PEG antibodies and reduce immunogenicity. Resulting nanoparticles may provide similar gene delivery capabilities, while preventing binding of anti‐PEG antibodies compared to PEGylated counterparts.
Yara Ensminger   +8 more
wiley   +1 more source

Early and Progressive Spinal Cord Atrophy in Spinocerebellar Ataxia Type 1

open access: yesMovement Disorders, EarlyView.
Abstract Background Spinocerebellar ataxia type 1 (SCA1) is a rare, autosomal dominant neurodegenerative disorder characterized by progressive cerebellar and brainstem degeneration. Previous studies have shown that spinal cord atrophy is also a key aspect of SCA1 neuropathology.
Colette J.M. Reniers   +11 more
wiley   +1 more source

A dataset of radiocarbon dates from Holarctic mammal collagen purified with high-quality chemistry. [PDF]

open access: yesSci Data
Herrando-Pérez S   +4 more
europepmc   +1 more source

Urologic Bacteriome: The Hero or the Villain in Prostate Cancer Onset, Progression, and Treatment?

open access: yesMedicinal Research Reviews, EarlyView.
ABSTRACT Prostate cancer (PCa) is the second most frequently diagnosed cancer in men worldwide and the fifth leading cause of cancer‐related mortality, presenting urgent unmet clinical needs in diagnosis and treatment. The recognition of the microbiome as a key factor in human health has prompted numerous studies, revealing an exciting new approach to ...
Lara R. S. Fonseca   +6 more
wiley   +1 more source

Yielding brace system as a next-generation lateral load mechanism for seismic resilient cities. [PDF]

open access: yesSci Rep
Rc B   +11 more
europepmc   +1 more source

Coexistence, crossover and extirpation in coalescent communities and ecotones

open access: yesOikos, EarlyView.
When two ecological communities come into contact, the strength of their mixing determines whether species coexist, extirpate, or extend their ranges. We present analytical formulas and simulations describing these transitions. Specifically, we derive abundance shifts upon community coalescence, identify the critical mixing strength leading to first ...
Martin Heidelman, Dervis Can Vural
wiley   +1 more source

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