Results 41 to 50 of about 15,855 (240)

Tissue Doppler systolic annular velocity and myocardial performance index as predictors of right ventricular affection and culprit lesion location in acute inferior myocardial infarction

The Egyptian Heart Journal, 2014
Aim: This study aims at using peak lateral tricuspid annular systolic velocity (ST) and right ventricular myocardial performance index (RV-MPI) as predictors of RV infarction (RVI) and subsequently localizing the culprit lesion in the proximal right ...
Walaa Adel, Viola William, Mary Josef, Nagwa Al-Mahallawy   +3 more
doaj   +1 more source

Synergistic Remodeling of Tumor Immune Microenvironment via a DNA Nanodevice Integrating STING Activation and Lysosome‐Targeted PD‐L1 Degradation

Advanced Science, EarlyView.
A rational design DNA nanoplatform not only achieves efficient PD‐L1 degradation but also triggers robust STING signaling. The nanodevice effectively reprograms “cold” tumors, leading to potent inhibition of tumor growth and metastasis in vivo. ABSTRACT The cGAS‐STING pathway is a cornerstone of innate antitumor immunity; however, its therapeutic ...
Haoxiang Li, Min Hou, Shasha Sun, Jun Cao, Jian‐Hui Jiang, Jianjun He   +5 more
wiley   +1 more source

AI‐Assisted Digital Single‐Molecule Activity Tracker for Decoupling Intrinsic Heterogeneity from Photo‐Oxidative Damage in High‐Photon‐Flux Enzymology

Advanced Science, EarlyView.
Employing a digital single‐molecule activity tracker (dSMAT), this research demonstrates that high‐photon‐flux irradiation drives progressive oxidative scarring in polymerases. Unlike simple thermal denaturation, real‐time kinetic tracking dynamically visualizes enzymes degrading into multiple impaired subpopulations.
Anran Zheng, Qi Yang, Jinze Li, Fuqiang Ma, Xuefeng Wang, Zhen Guo, Chuanyu Li, Dongshu Li, Jia Yao, Zhiqi Zhang, Wei Zhang, Lianqun Zhou   +11 more
wiley   +1 more source

PDGFRα+/Integrin α2+ Fibroblasts Orchestrate Tumor Budding in Oral Squamous Cell Carcinoma via Mechano‐Metabolic Symbiosis: E‐Cadherin/Integrin α2β1 Adhesion and Mitochondrial Transfer

Advanced Science, EarlyView.
PDGFA/PDGFRα signaling recruits CAFs to OSCC nests, and CAF‐OSCC contact drives tumor budding invasion. Mechanistically, heterotypic adhesion via E‐cadherin/integrin α2β1 activates YAP signaling in OSCC cells, inducing EMT. Concurrently, CAFs transfer mitochondria through TNTs, supplying ATP to fuel invasion.
Yufang Liu, Jiao Li, Juan Liu, Qi Dong, Haoyang Zhang, Yanjin Wang, Huibing Li, Ye Guan, Lei Cao, Manqing Zhang, Fangning Guo, Xue Liu, Zhen Yang, Mengmeng Lu, Hui Liu, Laiping Zhong, Tong Ji, Tingjiao Liu   +17 more
wiley   +1 more source

ANALYSIS OF THE RUSSIAN MACHINE BUILDING COMPLEX COMPETITIVENESS IN POST-CRISIS PERIOD

Russian Journal of Economics and Law, 2011
The article is devoted to the evaluation of competitive advantages and disadvantages of the machine building outputs at the external market. The work reviews recent structural changes in the Russian machine building sector.
O. V. Askanova, A. V. Karpenko
doaj  

Pericoronary adipose tissue inflammation mediates the atherogenic effects of lipids on multivessel coronary artery disease: a CCTA-based radiomics analysis

Frontiers in Cardiovascular Medicine
ObjectiveThe atherogenic index of plasma (AIP) is a robust predictor of cardiovascular risk. However, its mechanism of action in the severity of coronary artery disease (CAD) remains unknown.
Haimei Du, Junchen Zheng, Yaxin Yao, Qin Zhou, Linjuan Li   +4 more
doaj   +1 more source

Oscillating shear index, wall shear stress and low density lipoprotein accumulation in human RCAs

, 2011
Atherosclerosis shows predilection in regions of coronary arteries with hemodynamic particularities as, local disturbances of Wall Shear Stress (WSS) in space and time, and locally high concentrations of lipoprotein. Six, image-based human deceased, Right Coronary Arteries (RCA) are used to elucidate, a) Low Density Lipoprotein (LDL) transport under ...
Papaioannou, Vassilios, Soulis, Johannes, Fytanidis, Dimitrios, Giannoglou, George   +3 more
openaire   +2 more sources

ANXA2+ Small Extracellular Vesicles Drive Chemoresistance in Anaplastic Thyroid Cancer by Promoting XRCC5 Lactylation and Enhancing Non‐Homologous End‐Joining Repair

Advanced Science, EarlyView.
ANXA2+ sEVs promote cisplatin resistance in ATC by stabilizing the SRC/LDHA interaction, increasing LDHA phosphorylation and activity, and lactate production. Elevated lactate levels promote KAT5‐mediated lactylation of XRCC5 at lysine 265, enhancing its binding to XRCC6.
Shanshan Su, YiShan Xiong, Yuxuan Liang, Xiang Min, Daofeng Dai   +4 more
wiley   +1 more source

Competitiveness of dried sector: A case study of world and Turkey

Agricultural Economics (AGRICECON), 2020
The study aimed to reveal the competitiveness of the world dried sector for some selected products such as dried apples, prunes, apricots, figs, and grapes. In the study, the data was subjected to the Revealed Comparative Advantage (RCA), Relative Export
Tunahan Erdem
doaj   +1 more source

Radical‐Mediated In Situ Fluorescence Dye Deposition: A Simple Interfacial Signal Amplification Reaction for Ultrasensitive Immunoassay on Barcode Beads

Advanced Science, EarlyView.
A radical‐mediated in situ fluorescence dye deposition (RIFD) reaction containing merely three elements of beads, dyes, and radicals is discovered for the first time, and its underlying mechanism is elucidated. This simple RIFD enables the interfacial and ultrafast deposition of free dyes onto barcode beads, serving as a powerful signal amplification ...
Jiayu Zhang, Yao Wang, Xinyi Huang, Haiyu Wu, Qiuning Lin, Hongchen Gu, Li Jiang, Linyong Zhu, Hong Xu   +8 more
wiley   +1 more source