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KEYNOTE-811 pembrolizumab plus trastuzumab and chemotherapy for HER2+ metastatic gastric or gastroesophageal junction cancer (mG/GEJC): A double-blind, randomized, placebo-controlled phase 3 study.
Journal of Clinical Oncology, 2019 TPS4146 Background: Combination therapy with the anti-HER2 antibody trastuzumab with fluoropyrimidine and platinum is the current standard for patients with HER2+ mG/GEJc.Y. Janjigian, Y. Bang, C. Fuchs, S. Qin, T. Satoh, K. Shitara, J. Tabernero, E. Van Cutsem, Z. Cao, Xinqun Chen, S. Kang, C. Shih, H. Chung +12 moresemanticscholar +1 more sourceTrajectories of Suicidal Ideation During 12 Weeks of Escitalopram or Nortriptyline Antidepressant Treatment Among 811 Patients With Major Depressive Disorder.
Journal of Clinical Psychiatry, 2019 BACKGROUND
Suicidal ideation is a frequent and difficult-to-treat clinical challenge among patients with major depressive disorder (MDD). However, little is known regarding the differential development during antidepressant treatment and whether some ...T. Madsen, H. Buttenschøn, R. Uher, Ida Behrendt-Møller, N. Perroud, W. Maier, J. Hauser, M. Dernovšek, N. Henigsberg, D. Souery, M. Rietschel, P. McGuffin, K. Aitchison, O. Mors, Ole Köhler-Forsberg +14 moresemanticscholar +1 more sourceKEYNOTE-811 pembrolizumab plus trastuzumab and chemotherapy for HER2+ metastatic gastric or gastroesophageal junction cancer (mG/GEJc): A double-blind, randomized, placebo-controlled phase III study.
, 2019 TPS4146Background: Combination therapy with the anti-HER2 antibody trastuzumab with fluoropyrimidine and platinum is the current standard for patients with HER2+ mG/GEJc.H. Chung, Y. Bang, C. Fuchs, S. Qin, T. Satoh, K. Shitara, J. Tabernero, E. Cutsem, M. Alsina, Z. Cao, X. Chen, P. Bhagia, C. Shih, Y. Janjigian +13 moresemanticscholar +1 more sourceLBA-4 Initial data from the phase 3 KEYNOTE-811 study of trastuzumab and chemotherapy with or without pembrolizumab for HER2-positive metastatic gastric or gastroesophageal junction (G/GEJ) cancer
Annals of Oncology, 2021 Y. Janjigian, A. Kawazoe, P. Weber, S. Luo, S. Lonardi, O. Kolesnik, O. Barajas, Y. Bai, L. Shen, Yong Tang, L. Wyrwicz, K. Shitara, S. Qin, E. Cutsem, J. Tabernero, L. Li, C. Shih, P. Bhagia, H. Chung +18 moresemanticscholar +1 more sourceGlobal age-sex-specific mortality, life expectancy, and population estimates in 204 countries and territories and 811 subnational locations, 1950–2021, and the impact of the COVID-19 pandemic: a comprehensive demographic analysis for the Global Burden of Disease Study 2021
The LancetAustin E. Schumacher, H. Kyu, Amirali Aali, C. Abbafati, Jaffar Abbas, Rouzbeh Abbasgholizadeh, M. Abbasi, Mohammadreza Abbasian, S. ElHafeez, Michael Abdelmasseh, S. Abd-Elsalam, Ahmed Abdelwahab, Mohammad Abdollahi, M. Abdoun, Auwal Abdullahi, Ame Mehadi Abdurehman, Mesfin Abebe, Aidin Abedi, Armita Abedi, Tadesse M. Abegaz, R. Zuñiga, E. Abhilash, O. Abiodun, R. Aboagye, Hassan Abolhassani, M. Abouzid, Lucas Guimarães Abreu, Woldu Aberhe Abrha, Michael R. M. Abrigo, Dariush Abtahi, Samir Abu Rumeileh, Niveen M. E. Abu-Rmeileh, Salahdein Aburuz, A. Abu-Zaid, Juan Manuel Acuna, Tim Adair, Isaac Yeboah Addo, O. Adebayo, O. Adegboye, Victor Adekanmbi, Bashir Aden, Abiola Adepoju, C. Adetunji, T. Adeyeoluwa, O. Adeyomoye, Rishan Adha, Amin Adibi, W. Adikusuma, Qorinah Estiningtyas Sakilah Adnani, Saryia Adra, Abel Afework, A. Afolabi, Ali Afraz, Shadi Afyouni, Saira Afzal, P. Agasthi, Shahin Aghamiri, A. Agodi, Williams Agyemang-Duah, B. Ahinkorah, Aqeel Ahmad, Danish Ahmad, Firdos Ahmad, Muayyad M. Ahmad, Tauseef Ahmad, K. Ahmadi, Amir Mahmoud Ahmadzade, Mohadese Ahmadzade, Ayman Ahmed, Haroon Ahmed, Luai A. Ahmed, M. Ahmed, Syed Anees Ahmed, Marjan Ajami, Budi Aji, O. Ajumobi, G. T. Akalu, Essona Matatom Akara, K. Akinosoglou, Sreelatha Akkala, Samuel Akyirem, H. A. Hamad, Syed Mahfuz Al Hasan, Ammar Al Homsi, M. Qadire, Moein Ala, Timothy Olukunle Aladelusi, T. AL-Ahdal, Samer O. Alalalmeh, Z. Al-Aly, K. Alam, Manjurul Alam, Zufishan Alam, Rasmieh M. Al-amer, Fahad Mashhour Alanezi, Turki M. Alanzi, M. Albashtawy, Mohammad T. Albataineh, Robert W Aldridge, Sharifullah Alemi, A. Al-Eyadhy, A. Al-Gheethi, K. Alhabib, F. Alhalaiqa, M. K. Al-Hanawi, Abid Ali, Akhtar Ali, B. Ali, Hassam Ali, Mohammed Usman Ali, Rafat Ali, Syed Shujait Shujait Ali, Zahid Ali, S. A. Samakkhah, G. Alicandro, S. M. Alif, Mohammad Aligol, Rasoul Alimi, Ahmednur Adem Aliyi, Adel Al-Jumaily, S. Aljunid, W. Almahmeed, Sabah Al-Marwani, S. Al-Maweri, J. U. Almazan, Hesham M Al-Mekhlafi, Omar Almidani, Mahmoud A. Alomari, Nivaldo Alonso, J. Alqahtani, A. Alqutaibi, Salman Khalifah Al-Sabah, Awais Altaf, J. Al-Tawfiq, K. Altirkawi, F. J. Alvi, H. Alwafi, Y. Al-Worafi, Hany Aly, K. Alzoubi, Azmeraw T. Amare, E. Ameyaw, A. F. Amhare, Tarek Tawfik Amin, Alireza Amindarolzarbi, J. A. Dehkordi, Sohrab Amiri, Hubert Amu, D. Amugsi, J. Amzat, R. Ancuceanu, Deanna Anderlini, Pedro Prata Andrade, C. Andrei, Tudorel Andrei, Dhanalakshmi Angappan, Abhishek Anil, Afifa Anjum, Catherine M. Antony, E. Antriyandarti, Iyadunni A. Anuoluwa, S. Anwar, A. Anyasodor, Seth Christopher Yaw Appiah, M. Aqeel, J. Arabloo, R. Bahri, M. Arab-Zozani, Mosab Arafat, Ana Margarida Araújo, Aleksandr Y. Aravkin, A. Aremu, Hany Ariffin, T. Aripov, B. Armocida, Mahwish Arooj, A. Artamonov, K. D. Artanti, Judie Arulappan, Idowu Aruleba, R. T. Aruleba, Ashokan Arumugam, Malke Asaad, Saeed Asgary, Mubarek Yesse Ashemo, M. Ashraf, M. O. Asika, S. Athari, Maha Moh’d Wahbi Atout, A. Atreya, Sameh Attia, A. Aujayeb, Abolfazl Avan, A. Awotidebe, B. Quintanilla, M. Ayanore, Getnet Melaku Ayele, J. Ayuso-Mateos, S. M. Ayyoubzadeh, S. Azadnajafabad, G. Azhar, Shahkaar Aziz, A. Azzam, Mina Babashahi, Abraham Samuel Babu, Muhammad Badar, A. Badawi, A. Badiye, Soroush Baghdadi, Nasser Bagheri, S. Bagherieh, Sulaiman Bah, S. Bahadorikhalili, Jianjun Bai, Ruhai Bai, Jennifer L Baker, Shankar M. Bakkannavar, A. T. Bako, Senthilkumar Balakrishnan, Saliu A Balogun, Ovidiu Constantin Baltatu, Kiran Bam, Maciej Banach, Soham Bandyopadhyay, B. Banik, Palash Chandra Banik, Hansi Bansal, S. Barati, M. Barchitta, Mainak Bardhan, S. Barker-Collo, Francesco Barone-Adesi, H. Barqawi, Ronald D Barr, L. Barrero, Zarrin Basharat, Asma'u I J Bashir, H. Bashiru, P. Baskaran, Buddha Basnyat, Q. Bassat, João Diogo Basso, S. Basu, Kavita Batra, Ravi Batra, B. Baune, M. Bayati, N. Bayileyegn, Thomas Beaney, Neeraj Bedi, Tahmina Begum, Emad Behboudi, A. Behnoush, Maryam Beiranvand, Diana Fernanda Bejarano Ramirez, U. Belgaumi, Michelle L. Bell, A. Bello, Muhammad Bashir Bello, O. Bello, Luis Belo, Apostolos Beloukas, S. Bendak, Derrick A. Bennett, I. Benseñor, Habib Benzian, Zombor Berezvai, Adam E. Berman, A. N. Bermudez, P. J. Bettencourt, Habtamu B. Beyene, Kebede A. Beyene, D. Bhagat, A. Bhagavathula, Neeraj Bhala, Ashish Bhalla, Dinesh Bhandari, Nikha Bhardwaj, Pankaj Bhardwaj, Prarthna V. Bhardwaj, Ashish Bhargava, Sonu M M Bhaskar, Vivek Bhat, G. K. Bhatti, Jasvinder Singh Bhatti, M. Bhatti, Rajbir Bhatti, Z. Bhutta, B. Bikbov, Nada Binmadi, B. S. Bintoro, A. Biondi, C. Bisignano, F. Bisulli, Atanu Biswas, R. Biswas, Saeid Bitaraf, T. Bjørge, A. Bleyer, M. S. Boampong, V. Bodolica, Aadam Olalekan Bodunrin, Obasanjo Afolabi Bolarinwa, Milad Hashemi, A. Bonny, Kaustubh Bora, B. Basara, S. B. Borodo, Rohan Borschmann, Alejandro Botero Carvajal, S. Bouaoud, S. Boudalia, Edward J. Boyko, N. Bragazzi, Dejana Braithwaite, H. Brenner, Gabrielle Britton, A. Browne, A. Brunoni, Norma B. Bulamu, L. Bulto, Danilo Buonsenso, Katrin Burkart, Richard A. Burns, S. Nagaraja, Reinhard Busse, Yasser K. Bustanji, Z. Butt, F. C. Santos, Tianji Cai, D. Calina, L. Cámera, Luciana Aparecida Campos, Ismael Campos-Nonato, Chao Cao, Carlos Alberto Cardenas, Rosario Cárdenas, Sinclair Carr, Giulia Carreras, J. Carrero, A. Carugno, F. Carvalho, M. Carvalho, J. Castaldelli-Maia, C. Castañeda-Orjuela, G. Castelpietra, Ferrán Catalá-López, A. Catapano, M. Cattaruzza, A. Caye, Christopher R. Cederroth, Francieli Cembranel, Muthia Cenderadewi, Kelly M. Cercy, Ester Cerin, Muge Cevik, P. R. Chacón-Uscamaita, Yaacoub Chahine, C. Chakraborty, Jeffrey Shi Kai Chan, Chin-Kuo Chang, P. Charalampous, J. Charan, Vijay Kumar Chattu, V. Chatzimavridou-Grigoriadou, M. P. Chavula, H. Cheema, An-Tian Chen, Haowei Chen, Lingxiao Chen, Meng Xuan Chen, Simiao Chen, N. Cherbuin, Derek S. Chew, Gerald Chi, Jesus Lorenzo Chirinos-Caceres, Abdulaal Chitheer, So Mi Jemma Cho, William C. S. Cho, Bryan Chong, Hitesh Chopra, Rahul Choudhary, Rajiv Chowdhury, D. Chu, I. Chukwu, Eric Chung, Eunice Chung, Sheng-Chia Chung, K. Cini, Cain C T Clark, Kaleb Coberly, A. Columbus, H. Comfort, J. Conde, Sara Conti, P. Cortesi, V. M. Costa, Ewerton Cousin, R. Cowden, M H Criqui, N. Cruz-Martins, Garland T Culbreth, Patricia Cullen, Matthew Cunningham, Daniel da Silva e Silva, Sriharsha Dadana, O. Dadras, Zhaoli Dai, Koustuv Dalal, Lachlan L. Dalli, G. Damiani, Emanuele D'Amico, Sara Daneshvar, A. Darwesh, Jai K Das, Saswati Das, N. Dash, M. Dashti, C. Dávila-Cervantes, N. Weaver, K. Davletov, Diego De Leo, Aklilu Tamire Debele, L. Degenhardt, Reza Dehbandi, Lee Deitesfeld, Iván Delgado-Enciso, Laura Delgado-Ortiz, Daniel Demant, Berecha Hundessa Demessa, A. K. Demetriades, Xinlei Deng, E. Denova-Gutiérrez, Kebede Deribe, Nikolaos Dervenis, D. C. Jarlais, Hardik D. Desai, Rupak Desai, K. Deuba, Vinoth Gnana Chellaiyan Devanbu, Sourav Dey, A. Dhali, K. Dhama, M. Dhimal, M. Dhimal, Sameer Dhingra, D. Silva, Daniel Diaz, Adriana Dima, Delaney D Ding, M. Dirac, Abhinav Dixit, S. Dixit, Thanh Chi Do, Thao Huynh Phuong Do, Camila Bruneli do Prado, Masoud Dodangeh, K. Dokova, Christiane Dolecek, E. R. Dorsey, Wendel Mombaque dos Santos, Rajkumar Doshi, L. Doshmangir, Abdel Douiri, Robert Kokou Dowou, T. Driscoll, Haneil Larson Dsouza, John Dube, S. Dumith, S. Dunachie, Bruce B Duncan, A. Durães, Senbagam Duraisamy, O. Durojaiye, S. Dutta, Paulina A. Dzianach, Arkadiusz Marian Dziedzic, Oluwakemi Ebenezer, E. Eboreime, Alireza Ebrahimi, C. Echieh, Abdelaziz Ed-Dra, H. Edinur, D. Edvardsson, Kristina Edvardsson, Defi Efendi, Ferry Efendi, Shayan Eghdami, T. Eikemo, E. Eini, Michael Ekholuenetale, Emmanuel Ekpor, T. Ekundayo, Rabie Adel El Arab, Doaa Abdel Wahab El Morsi, M. Zaki, M. Tantawi, I. Elbarazi, N. Elemam, F. Elgar +499 moresemanticscholar +1 more source1400O Final overall survival for the phase III, KEYNOTE-811 study of pembrolizumab plus trastuzumab and chemotherapy for HER2+ advanced, unresectable or metastatic G/GEJ adenocarcinoma
Annals of OncologyY. Janjigian, A. Kawazoe, Y. Bai, J. Xu, S. Lonardi, J-P. Metges, P. Yanez Weber, L. Wyrwicz, L. Shen, Y. Ostapenko, M. Bilici, H. Chung, K. Shitara, M. Mahave, E. Van Cutsem, J. Tabernero, L. Xu, K. Sharan, P. Bhagia, S. Rha +19 moresemanticscholar +1 more source128MO Final overall survival for the phase III, KEYNOTE-811 study of pembrolizumab plus trastuzumab and chemotherapy for HER2+ advanced, unresectable or metastatic G/GEJ adenocarcinoma
Annals of OncologyS. Rha, A. Kawazoe, Y. Bai, J. Xu, S. Lonardi, J-P. Metges, P. Weber, L. Wyrwicz, L. Shen, Y. Ostapenko, M. Bilici, H. Chung, K. Shitara, M. Mahave, E. Van Cutsem, J. Tabernero, L. Xu, K. Sharan, P. Bhagia, Y. Janjigian +19 moresemanticscholar +1 more source
