Results 141 to 150 of about 618,204 (291)

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

FEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee, Dimitrios Bekiari, Sofia Doello, Karl Forchhammer   +3 more
wiley   +1 more source

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

Mechanisms of IgE‐mediated food allergy and the role of allergen‐specific B cells

FEBS Letters, EarlyView.
Food allergy arises when allergen‐specific B cells preferentially produce immunoglobulin E (IgE) antibodies against harmless foods. This article explains the mechanisms driving IgE‐mediated reactions, highlights the central role of these B cells, and discusses how natural tolerance (NT) and oral immunotherapy (OIT) can reshape allergic immune responses.
Juan‐Felipe López, Özge Yilmaz Ardicli, Mübeccel Akdis   +2 more
wiley   +1 more source

Translating PEARLS: lessons learned from providers and participants

Frontiers in Public Health, 2015
Mark B Snowden, Lesley E Steinman, Pamela ePiering, Sluggo eRigor, Andrea eYip   +4 more
doaj   +1 more source

Terve koululainen -hankkeen arviointi RE-AIM-mallin mukaan

, 2019
Lasten ja nuorten fyysinen aktiivisuus on terveen kasvun ja kehityksen perusta, ja kouluympäristö on ratkaisevassa roolissa oppilaiden liikunnan ilon ja innon ylläpitämisessä. Terve koululainen (TEKO) -hankkeessa on vuosien 2010–2018 aikana edistetty ala- ja yläkouluikäisten liikkumisen turvallisuutta ja sittemmin myös liikuntaa koulussa ja vapaa ...
openaire   +1 more source

Interventions to improve physical activity during pregnancy: a systematic review on issues of internal and external validity using the RE-AIM framework [PDF]

, 2017
Allen, Antikainen, Avery, Barakat, Barakat, Baumann, Blackman, Bo, Callaway, Canadian Society for Exercise Physiology, Chasan-Taber, Chasan-Taber, Choi, Cobiac, Cohen, Currie, Davis, de Oliveria Melo, Dekker Nitert, Department of Health, Department of Health and Human Services, Dodd, Dodd, Dodd, Dombrowski, Domenjoz, Engberg, Evenson, Evenson, Fabio, Gaglio, Galaviz, Gardner, Gaston, Gaston, Glasgow, Glasgow, Green, Guelinckx, Gustafsson, Halse, Harrison, Harrison, Hawkins, Hawkins, Hill, Hill, Ho, Hui, Hui, Hui, Jackson, Jing, Jukic, Kinnunen, Kong, Lando, Liberati, Liquori, Matthews, Mendelson, Mendelson, Miquelutti, Miquelutti, Moya, Mudd, Mustila, Mustila, Oostdam, Oostdam, Oostdam, Owen, Pagoto, Payne, Pearce, Perales, Petrov Fieril, Phelan, Pollak, Polley, Poston, Rauh, Russo, Salvesen, Skouteris, Skouteris, Smith, Stafne, Stafne, Stafne, Steckler, Streuling, Symons Downs, Tarquinio, Teychenne, Tobias, Ussher, Ussher, Victora, Vinter, Vinter, White, Wilkinson, Wilkinson   +103 more
core   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source