Results 111 to 120 of about 8,884,430 (245)

Treatment with KCL‐286, a first‐in‐class retinoic acid receptor‐β (RARβ) agonist, ameliorates neuronal DNA damage and inflammation in a mouse model of Alzheimer's disease

FEBS Open Bio, EarlyView.
Repair of neuronal DNA damage in Alzheimer's disease by KCL‐286. (A) Amyloid‐β oligomers and plaques impair neuronal DNA repair pathways, leading to DNA double‐strand breaks and glial activation. (B) KCL‐286 activates RARβ/RXR signalling via retinoic acid response elements (RAREs), associated with increased BRCA1 expression, enhanced DNA repair and ...
Natasha Hill, Hassan Yousef Othman AlMuallim, Elouisa Maddock, Carl Hobbs, Earl Clarke, Maria B. Goncalves, Jonathan P. T. Corcoran   +6 more
wiley   +1 more source

Dataset of Re-Entrant Crash Box

This dataset presents data related to crashworthiness indicators. This dataset is simulation of square re-entrant crash box. The square crash box specimens incorporating various re-entrant infill configurations (in-plane, out-of-plane, and ...
Fachrudin, Arif Rochman
core   +1 more source

Modeling and Analysis of Re-entrant Production Systems [PDF]

, 2006
This paper presents a model and analysis of a re-entrant production line with finite buffers and unreliable machines. Semiconductor device and liquid crystal display (LCD) fabrication processes are characterized as a re-entrant process, in which a ...
Gershwin, Stanley B., Jang, Young Jae
core  

Pathways and pitfalls: a qualitative study of student experiences in biomedical science education

FEBS Open Bio, EarlyView.
Biomedical science students from underrepresented backgrounds face barriers including financial strain, disrupted laboratory access and cultural exclusion. Peer networks provide vital support when institutional systems are difficult to navigate. To create inclusive learning environments and achieve academic success, educators should blend active, hands‐
Olivia J. Russell, Cassy Ross, Panagiota S. Filippou, Bruno Silvester Lopes, Dominic Gilchrist, Paul Dean, Kamar Ameen‐Ali, Tora K. Smulders‐Srinivasan, Ahmad A. Khundakar   +8 more
wiley   +1 more source

Mechanical properties of foam-filled hexagonal and re-entrant honeycombs under uniaxial compression

, 2022
Auxetic materials have excellent mechanical properties, e.g., indentation resistance, shear resistance, fracture toughness and energy absorption. However, the stiffness of auxetics is normally lower than that of solid structures due to the existence of ...
Yi Zhang (9093), Xiang Zhang (19800), Xin Ren (1999087), Yimin Xie (18029101), Xue Zhang (166886), Hui Luo (588276), Chen Luo (302288), Xian Cheng (1671859)   +7 more
core  

Importin 7 mediates the nuclear import of HIV‐1 integrase via a specific interacting interface

FEBS Open Bio, EarlyView.
HIV‐1 integrase enables viral DNA integration into the host genome. By binding to the core domain of the host protein Importin 7 via its C‐terminal domain, the integrase is transported across the nuclear membrane into the nucleus, where integration of the viral genome into host DNA takes place. This translocation is a critical step for subsequent viral
Juana Bana, Avigail Yariv, Tal Oppenheim, Hadar Amartely, Dana Reichmann, Oded Livnah   +5 more
wiley   +1 more source

Geometry and constraint dependent energy absorption and mechanical responses of finite elastomeric 3D-printed auxetic structures

International Journal of Lightweight Materials and Manufacture
Auxetic structures, characterised by negative Poisson’s ratios, exhibit exceptional energy absorption and controlled deformation making them ideal for applications in soft robotics, wearable sensors, biomedical devices, and structural monitoring.
John Millar, David Alonso-Caneiro, Umer Izhar, Damon Kent   +3 more
doaj   +1 more source

Identification of (20R)‐protopanaxadiol from Panax ginseng as a novel anti‐SARS‐CoV‐2 compound

FEBS Open Bio, EarlyView.
We established a noninfectious BAC‐based SARS‐CoV‐2 replicon that enables antiviral screening under BSL‐2 conditions. Using this platform, we screened 373 food‐derived compounds and identified (20R)‐protopanaxadiol from Panax ginseng as a novel inhibitor of SARS‐CoV‐2 RNA replication, highlighting the value of safe replicon systems for antiviral ...
Midori Takeda, Natsue Maezono, Rina Uchikoshi, Nobuyuki Kato, Masanori Ikeda   +4 more
wiley   +1 more source

The Role of Re-Entrant Microstructures in Modulating Droplet Evaporation Modes

The evaporation dynamics of sessile droplets on re-entrant microstructures are critical for applications in microfluidics, thermal management, and self-cleaning surfaces. Re-entrant structures, such as mushroom-like shapes with overhanging features, trap
Nguyen, Nam-Trung, Hoang Huy Vu, Navid Kashaninejad, Vu, Hoang Huy, Kashaninejad, Navid, Nam-Trung Nguyen   +5 more
core   +1 more source

Structural studies and functional engineering of NanX: an anhydro‐sialic acid transporter from Escherichia coli

FEBS Open Bio, EarlyView.
Biophysical characterisation shows that NanX, a membrane transport protein from the major facilitator superfamily (MFS), forms both monomers and dimers after purification. AlphaFold modelling and substrate docking provide information on residues likely involved in substrate recognition for NanX and another MFS member, NanT.
Michael C. Newton‐Vesty, Kelsi R. Hall, Zachary D. Tillett, Liam S. Turk, James S. Davies, Michael J. Currie, Hamish G. Brown, Sepideh Valimehr, Peter D. Mace, Andrew E. Whitten, Santosh Panjikar, Eric Hanssen, Rachel A. North, Renwick C.J. Dobson   +13 more
wiley   +1 more source