Results 241 to 250 of about 4,532,035 (362)

Proteasomal degradation of intracellularly expressed Amblyomin‐X limits suicide gene therapy potential in melanoma cells

FEBS Open Bio, EarlyView.
This study explores the feasibility of expressing the antitumoral protein Amblyomin‐X through a suicide gene therapy approach and investigates its intracellular fate after gene delivery. Although the gene is efficiently expressed, melanoma cells rapidly degrade the Amblyomin‐X protein via proteasome activity.
Victor Dal Posolo Cinel, Carlos DeOcesano Pereira, Aline Ramos Maia Lobba, Melissa Regina Fessel, Ana Marisa Chudzinski‐Tavassi   +4 more
wiley   +1 more source

The Hidden Persistence of Deep-Sea Pollution. [PDF]

Environ Sci Technol
Dachs J, Serrano C, Trilla-Prieto N, Grande-Martí J, Fernández-Altimira M, Patrone J, Berrojalbiz N, Méjanelle L, Vila-Costa M.   +8 more
europepmc   +1 more source

Rapid screening of staphylokinase protein variants using an unpurified cell‐free expression system

FEBS Open Bio, EarlyView.
An unpurified cell‐free protein synthesis (CFPS) platform enables rapid functional screening of staphylokinase variants. Direct plasminogen‐activation assays performed in microplate format provide real‐time activity readouts, allowing rapid identification and ranking of variants with improved or reduced fibrinolytic activity without protein ...
Maria Tomková, Veronika Hovanová, Jiri Damborsky, Erik Sedlák   +3 more
wiley   +1 more source

Comparison of Upper Body Joint and Hand Motions in Eating Solid Foods With Chopsticks and Semisolid Foods With a Spoon in Healthy Males and Females: Observational Study. [PDF]

JMIR Rehabil Assist Technol
Nakatake J, Maeda S, Miyazaki S, Arakawa H, Chosa E.   +4 more
europepmc   +1 more source

Research on the Human Proteome Reaches a Major Milestone: >90% of Predicted Human Proteins Now Credibly Detected, According to the HUPO Human Proteome Project

, 2020
Gilbert S. Omenn, Lydie Lane, Christopher M. Overall, Ileana M. Cristea, Fernando J. Corrales, Cecilia Lindskog, Young‐Ki Paik, Jennifer E. Van Eyk, Siqi Liu, Stephen R. Pennington, M Snyder, Mark S. Baker, Nuno Bandeira, Ruedi Aebersold, Robert L. Moritz, Eric W. Deutsch   +15 more
openalex   +2 more sources

Evolutionarily divergent DUF4465 domains have a common vitamin B12‐binding function

FEBS Open Bio, EarlyView.
We show that DUF4465 family proteins, widespread across bacteria from gut microbiomes, hydrothermal vents, and soil, share a common vitamin B12‐binding function. These augmented β‐jellyroll proteins bind vitamin B12 via extended loops. Our findings establish sequence‐diverse DUF4465 proteins as a widespread class of B12‐binding proteins, highlighting ...
Charlea Clarke, Michal Banasik, Rokas Juodeikis, Martin J. Warren, Richard W. Pickersgill   +4 more
wiley   +1 more source

New insights into acremonium-like fungi in <i>Hypocreales</i>: A taxonomic and phylogenetic perspective. [PDF]

Stud Mycol
Zhao L, Groenewald JZ, Hou LW, Starink-Willemse M, Beek B, Grum-Grzhimaylo OA, Summerbell RC, Crous PW.   +7 more
europepmc   +1 more source

Canopy interception by a spruce forest in the upper reach of Heihe River basin, Northwestern China

, 2013
Huanhua Peng, Chuanyan Zhao, Zhaodong Feng, Zhonglin Xu, Chao Wang, Yang Zhao   +5 more
openalex   +2 more sources

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Three New Cryptic Species of the Freshwater Shrimp Genus <i>Caridina</i> (Decapoda: Caridea: Atyidae) from Hong Kong, with Notes on the <i>C. serrata</i> Species Group. [PDF]

Zool Stud
Chow LH, Chan JCF, Leung JHC, Tsang LM.
europepmc   +1 more source