Results 181 to 190 of about 435,439 (266)

Reclassification of GST Allergens Based on Their Cross-Reactivity in Two Divergent Cockroach Species. [PDF]

Clin Exp Allergy
Zong G, Lozano A, Leighton GO, Randall T, Pedersen LC, Glesner J, Smith BRE, Acevedo N, Schal C, Caraballo L, Pomés A, Zakzuk J, Mueller GA.   +12 more
europepmc   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

Retraining Alcohol and Condom Tendencies (ReACT) intervention among women with a history of rape: A secondary analysis of a proof-of-principle study. [PDF]

Exp Clin Psychopharmacol
Hahn AM, Hahn CK, Simons RM, Simons JS.
europepmc   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

Silanes to Silatranes: Robust Functionalization for Single-Molecule Force Spectroscopy. [PDF]

Chembiochem
Courtney TD, Hatchell CB, O X, Jacobson DR.   +3 more
europepmc   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

Stringent selection on kinetics of condensation reactions: early steps in chemical evolution.

Phys Chem Chem Phys
Capera-Aragones P, Matange K, Rajaei V, Pinter Y, Petrov AS, Williams LD, Frenkel-Pinter M.   +6 more
europepmc   +1 more source

Validating molecular target-enriched fMRI for disentangling drug effects on dopamine. [PDF]

Imaging Neurosci (Camb)
van den Bosch R, Cools R.
europepmc   +1 more source

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source

Correction: The realism of behavioral theory-based vs. non-theory-based AI agents during a simulated infant formula shortage. [PDF]

Front Artif Intell
Desens L, Walling B, O'Neill R, Howard V, Giammarino M, Scannell D, Kemble A, Wilkerson T, Nhial N, Elson SB, Leahy M, Rosen S.   +11 more
europepmc   +1 more source