Results 101 to 110 of about 4,841,861 (299)
Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation
FEBS Letters, EarlyView.Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz +11 more
wiley +1 more source
FEBS Letters, EarlyView.Mitochondrial remodeling shapes neural and glial lineage progression by matching metabolic supply with demand. Elevated OXPHOS supports differentiation and myelin formation, while myelin compaction lowers mitochondrial dependence, revealing mitochondria as key drivers of developmental energy adaptation.
Sahitya Ranjan Biswas +3 more
wiley +1 more source
Aggressive prostate cancer is associated with pericyte dysfunction
Molecular Oncology, EarlyView.Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero +11 more
wiley +1 more source
A boundary control problem with a nonlinear reaction term
Electronic Journal of Differential Equations, 2009 The authors study the problem $u_t=u_{xx}-au$, $0<x<1$, $t>0$; $u(x,0)=0$, and $-u_x(0,t)=u_x(1,t)=phi(t)$, where $a=a(x,t,u)$, and $phi(t)=1$ for $t_{2k} < t<t_{2k+1}$ and $phi(t)=0$ for $t_{2k+1} <t<t_{2k+2}$, $k=0,1,2,ldots$ with
John R. Cannon, Mohamed Salman
doaj
Molecular Oncology, EarlyView.Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra +10 more
wiley +1 more source
Microwave-assisted Cannizzaro reaction—Optimisation of reaction conditions
Synthetic Communications, 2019 The microwave-assisted Cannizzaro reaction was studied in order to develop fully reproducible synthetic protocols for transformation of aldehydes to carboxylic acid and alcohols. Optimised were the following process parameters: power, temperature, and time. Aromatic, heteroaromatic and aliphatic aldehydes were used in the studies.
Łukasz Janczewski +4 more
openaire +1 more source
Molecular Oncology, EarlyView.We developed and validated a DNA methylation–based biomarker panel to distinguish pleural mesothelioma from other pleural conditions. Using the IMPRESS technology, we translated this panel into a clinically applicable assay. The resulting two classifier models demonstrated excellent performance, achieving high AUC values and strong diagnostic accuracy.
Janah Vandenhoeck +12 more
wiley +1 more source
Asymptotic behavior of solutions of a reaction diffusion equation with free boundary conditions
, 2014 We study a nonlinear diffusion equation of the form $u_t=u_{xx}+f(u)\ (x\in [g(t),h(t)])$ with free boundary conditions $g'(t)=-u_x(t,g(t))+\alpha$ and $h'(t)=-u_x(t,g(t))-\alpha$ for some $\alpha>0$.
Cai, Jingjing +2 more
core +1 more source
Molecular Oncology, EarlyView.We developed a cost‐effective methylation‐specific droplet digital PCR multiplex assay containing tissue‐conserved and tumor‐specific methylation markers. The assay can detect circulating tumor DNA with high accuracy in patients with localized and metastatic colorectal cancer.
Luisa Matos do Canto +8 more
wiley +1 more source
Rate of convergence of attractors of reaction-diffusion equations with nonlinear boundary conditions
, 2020 This paper we study the rate of convergence of the asymptotic dynamics of reaction-diffusion equations with nonlinear Robin boundary conditions. We show how the rate of convergence of the global attractors can be affected by the variation of the ...
Bezerra, Flank David Moraes +1 more
core