Results 181 to 190 of about 14,968,723 (400)

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

CMLSnap: Animated reaction mechanisms

, 2004
Reactions with many steps can be represented by a single XML-based table of the atoms, bonds and electrons. For each step the complete Chemical Markup Language1 representation of all components is given. These snapshots can then be combined to give an animated description of the complete reaction, both in "2D" chemical structure diagrams and in three ...
Holliday, G L, Mitchell, John B. O., Murray-Rust, P   +2 more
openaire   +2 more sources

A complete and sustained organic/inorganic reaction mechanism of Baeyer’s test [PDF]

Francisco Sánchez Viesca, Reina Gómez
openalex   +1 more source

Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer

Molecular Oncology, EarlyView.
PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta, Yang Song, Madeleine Ndahayo, Anirudh Saxena, Theresa Guo, Dylan Z. Kelley, Jessica Gore, Andrew Hennigan, Alexa Anderson, John C. Papadimitriou, Daria A. Gaykalova   +10 more
wiley   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

<i>N</i>-Chlorination of Sulfonamides: DFT Study of the Reaction Mechanism. [PDF]

J Phys Chem A
Ljulj A, Škibola P, Turkalj D, Vrček V.   +3 more
europepmc   +1 more source

Supplementary material to "Multiphase reactions of aromatic organosulfates with OH radicals: Kinetics, mechanisms, and environmental effects"

Yang Yu, Caiqing Yan, Ruyu Yuang, Ping Liu, Hanyuan Zhang, Haibiao Chen, Yujiao Zhu, Hengqing Shen, Yan Wu, Likun Xue, Liubin Huang   +10 more
openalex   +1 more source

3P136 Reconstruction of feather bud patterning by a reaction-diffusion mechanism during bioengineered skin development in 3D culture(09. Development & Differentiation,Poster,The 52nd Annual Meeting of the Biophysical Society of Japan(BSJ2014))

, 2014
Kentaro Ishida, Toshiyuki Mitsui
openalex   +2 more sources

Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin

Molecular Oncology, EarlyView.
Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon, Dong Young Kim, Yuna Kim, Uk‐Il Kim, Jae‐Sung Kim   +4 more
wiley   +1 more source

An S_N2 reaction mechanism for hydrolysis of siloxane linkages and the implications for dissolution of quartz. [PDF]

Sci Rep
Watts HD, Kubicki JD.
europepmc   +1 more source