Results 51 to 60 of about 2,991,068 (282)

Diversity of the reaction mechanisms of SAM-dependent enzymes

Acta Pharmaceutica Sinica B, 2021
S-adenosylmethionine (SAM) is ubiquitous in living organisms and is of great significance in metabolism as a cofactor of various enzymes. Methyltransferases (MTases), a major group of SAM-dependent enzymes, catalyze methyl transfer from SAM to C, O, N ...
Qiu Sun, Mengyuan Huang, Yuquan Wei
doaj   +1 more source

Peptide‐based ligand antagonists block a Vibrio cholerae adhesin

FEBS Letters, EarlyView.
The structure of a peptide‐binding domain of the Vibrio cholerae adhesin FrhA was solved by X‐ray crystallography, revealing how the inhibitory peptide AGYTD binds tightly at its Ca2+‐coordinated pocket. Structure‐guided design incorporating D‐amino acids enhanced binding affinity, providing a foundation for developing anti‐adhesion therapeutics ...
Mingyu Wang, Grace Du, Charity Yongo‐Luwawa, Angelina Lu, Brett Kinrade, Kim Munro, Karl E. Klose, William D. Lubell, Peter Davies, Shuaiqi Guo   +9 more
wiley   +1 more source

Crystal structure of zwitterionic 3,3′-[1,1′-(butane-1,4-diyl)bis(1H-imidazol-3-ium-3,1-diyl)]bis(propane-1-sulfonate) dihydrate

Acta Crystallographica Section E: Crystallographic Communications, 2020
The crystal structure of the title compound, C16H26N4O6S2·2H2O, a water-soluble di-N-heterocyclic carbene ligand precursor was determined using a single crystal grown by the slow cooling of a hot N,N-dimethylformamide solution of the compound.
Antal Udvardy, Sourav De, Tamás Gyula Gál, Gábor Papp, Csilla Enikő Czégéni, Ferenc Joó   +5 more
doaj   +1 more source

Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing

FEBS Letters, EarlyView.
Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley   +1 more source

Mechanisms of metasomatic reactions [PDF]

Mineralogy and Petrology, 2009
Fluid-aided mass transfer and subsequent mineralre-equilibrationarethetwodefiningfeaturesofmetasomatismand must be present in order for metamorphism to occur.Taking into account geological time scales, the amount offluidrequiredneednotbegreat(considerablylessthan0.01%of the total volume) nor even in continuous flow but the fluidmust be chemically ...
Harlov, D., Marschall, H.
openaire   +4 more sources

A candidate LiBH4 for hydrogen storage: Crystal structures and reaction mechanisms of intermediate phases [PDF]

, 2005
First-principles calculation and x-ray diffraction simulation methods have been used to explore crystal structures and reaction mechanisms of the intermediate phases involved in dehydriding of LiBH4. LiBH4 was found to dehydride via two sequential steps:
Goddard, William A., III, Han, Young Soo, Kang, Jeung Ku, Kim, Se Yun, Muller, Richard P.   +4 more
core   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

Analysis of auto-ignition of heated hydrogen-air mixtures with different detailed reaction mechanisms [PDF]

, 2011
Auto-ignition processes of hydrogen, diluted with nitrogen, in heated air are numerically investigated by means of an unsteady laminar flamelet approach in mixture fraction space. The focus is on the auto-ignition delay time and the most reactive mixture
Merci, Bart, Stankovic, Ivana
core   +1 more source

Time after time – circadian clocks through the lens of oscillator theory

FEBS Letters, EarlyView.
Oscillator theory bridges physics and circadian biology. Damped oscillators require external drivers, while limit cycles emerge from delayed feedback and nonlinearities. Coupling enables tissue‐level coherence, and entrainment aligns internal clocks with environmental cues.
Marta del Olmo, Carolin Ector, Hanspeter Herzel   +2 more
wiley   +1 more source

Molecular mechanisms at the basis of the protective effect exerted by EPPS on neurodegeneration induced by prefibrillar amyloid oligomers

Scientific Reports
It has been shown recently, without an explanation of the possible molecular mechanisms involved, that 4-(2-hydroxyethyl)-1-piperazinepropanesulphonic (EPPS) acid effectively protects from the neurotoxicity induced by oligomers and plaques formed by the ...
Beatrice Zarrilli, Roberto Bonanni, Marcello Belfiore, Mariagrazia Severino, Ida Cariati, Raoul Fioravanti, Giacomo Cappella, Simona Sennato, Claudio Frank, Cristiano Giordani, Virginia Tancredi, Cecilia Bombelli, Marco Diociaiuti, Giovanna D’Arcangelo   +13 more
doaj   +1 more source