Results 71 to 80 of about 1,432,567 (263)

The therapeutic opportunities and pitfalls of using iron ion chelators to treat neurodegenerative diseases

FEBS Letters, EarlyView.
Although too much iron in the brain promotes neurodegeneration, iron ion chelators have had mixed effects in clinical trials. This review explains why; some chelators do not render the iron redox‐inactive (e.g., L1) whereas others do (e.g., desferrioxamine).
Barry Halliwell
wiley   +1 more source

An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes

FEBS Letters, EarlyView.
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg, Martine Hjeltnes, Josephine Krieger, Joshua E. Elias, Maria Stensland, Kristian Holm, Xiaojun Jiang, Chuki Khangsar, Tuula A. Nyman, Arthur Kaser, Johannes R. Hov, Tom H. Karlsen, Nicole C. Kaneider, Frode L. Jahnsen, Georg Schneditz   +14 more
wiley   +1 more source

Stereochemical aspects of the nucleophilic attack in different classes of l-asparaginases

IUCrJ
L-Asparaginases hydrolyze L-asparagine to L-aspartate with the release of ammonia. Currently, three completely unrelated structural classes of L-asparaginases are known, further subdivided into five types.
Miroslaw Gilski, Kinga Pokrywka, Mariusz Jaskolski   +2 more
doaj   +1 more source

Elastic and inelastic scattering of 15n ions by 11B at 84 MeV [PDF]

Ядерна фізика та енергетика, 2014
Angular distributions of the 11B + 15N elastic and inelastic scattering were measured at Elab (15N) = 84 MeV. The data were analyzed within the optical model and coupled-reaction-channels method.
A. T. Rudchik, O. V. Herashchenko, K. A. Chercas, A. A. Rudchik, S. Kliczewski, Val. M. Pirnak, E. Piasecki, K. Rusek, A. Trczińska, S. B. Sakuta, R. Siudak, I. Strojek, A. Stolarz, E. I. Koshchy, A. O. Barabash, A. P. Ilyin, O. A. Ponkratenko, Yu. M. Stepanenko, V. V. Uleshchenko, Yu. O. Shyrma, J. Choiński, A. Szczurek   +21 more
doaj  

Epigenetic reprogramming of lineage switching in cancer

FEBS Letters, EarlyView.
Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı, Burcu Akman, Ezgi Bağırsakçı, Nese Atabey, Serap Erkek‐Ozhan   +4 more
wiley   +1 more source

The microbiome in human skin aging

FEBS Letters, EarlyView.
Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana, Cornelia Wiegand, Omid Omrani, Mario Fabri   +3 more
wiley   +1 more source

Identifying Beneficial and Adverse Co4+ Species in Cobalt‐Based Oxygen Evolution Catalysts via Precursor Polymorphism Engineering

Advanced Science
The oxygen evolution reaction (OER) is a critical bottleneck in water electrolysis for hydrogen production, necessitating catalysts that optimize both efficiency and cost.
Zhongheng Li, Zheng Shu, Lun Li, Wendi Zhang, Jiaqian Kang, Chengcheng Zhong, Ziwen Feng, Jinxian Feng, Hou Ian, Hui Pan   +9 more
doaj   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Shining light on non-platinum-based electrocatalysts for efficient ammonia oxidation in low-temperature direct ammonia fuel cells: Fundamentals, progress, and perspectives

Nano Research
In response to growing energy and environmental concerns associated with fossil fuels, renewable energy-powered fuel cells have gained significant attention as sustainable alternatives.
Xiaowei Shen, Qiyang Cheng, Sisi Liu, Yunfei Huan, Yanzheng He, Fengchun Zhou, Mengfan Wang, Chenglin Yan, Tao Qian   +8 more
doaj   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source