Results 131 to 140 of about 338,740 (309)
Reactivity Hypothesis adult reactivity versus child reactivity
The phenomenom of reactivity is such that if one tells a person that the person is recorded each time the person says the word 'like' the person is saying it less than if the person would have not known the word is going to be recorded, i.e. the person being monitored. A good example is described in the book David H. Barlow & V. Mark Durand, 2012, 2009
openaire +1 more source
Autoimmune Encephalitis in Acute Care—Pathology, Diagnosis, and Management
Advanced Science, EarlyView.ABSTRACT Autoimmune encephalitis (AE) is characterized by immune‐mediated inflammation of the brain parenchyma, presenting with various neurological syndromes, including but not limited to seizures, altered consciousness, neuropsychiatric symptoms, and movement disorders.
Suneesh Thilak +9 more
wiley +1 more source
Reactivation of Bovine Tuberculosis in Patient Treated with Infliximab, Switzerland
Emerging Infectious Diseases, 2009 Marina Nager +7 more
doaj +1 more source
Advanced Science, EarlyView.Pancreatic neuroendocrine tumors frequently silence MEN1 through epigenetic mechanisms. Here, SIRT7 recruits DNMT1 to the MEN1 promoter, drives hypermethylation, and enhances DNA repair. Inhibiting SIRT7 restores MEN1, reduces MRN complex abundance, impairs double‐strand break repair, and sensitizes PanNET models to radiation, supporting SIRT7 as a ...
Jianyun Jiang +11 more
wiley +1 more source
Advanced Science, EarlyView.When a master transcription factor (TF) is lost, bacteria can rapidly rewire gene regulatory networks by co‐opting related regulators. Using experimental evolution in Pseudomonas fluorescens, we show that TF promiscuity (low‐level, non‐cognate binding) provides the raw material for rewiring. Successful co‐option follows a predictable hierarchy governed
Tiffany B. Taylor, Alan M. Rice
wiley +1 more source
Targeting EBV Episome for Anti-Cancer Therapy: Emerging Strategies and Challenges
VirusesAs a ubiquitous human pathogen, the Epstein–Barr virus (EBV) has established lifelong persistent infection in about 95% of the adult population. The EBV infection is associated with approximately 200,000 human cancer cases and 140,000 deaths per year ...
Febri Gunawan Sugiokto, Renfeng Li
doaj +1 more source
Reactivity of Cyclopropenylaluminates
OrganometallicsReactions of the potassium cyclopropenylaluminates, [{SiNDipp}-Al-η2-(C2Ph2)-K] and [{SiNDipp}-Al-η2-(PhCCSiMe3)-K] with terminal alkynes provide alkynylvinylaluminate derivatives with the silyl-substituted analog providing a level of kinetic discrimination. While this latter behavior results in the regiochemical protonation at Al-C-(Ph) and retention
Marco F. Starostzik +4 more
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Advanced Science, EarlyView.We propose the Full‐Body AI Agent, a multi‐scale collaborative framework with 7 biological‐layer agents. It unifies multi‐omics/clinical data via standardized protocols, enabling phenotype‐guided closed‐loop reasoning, quantitative evaluation, and LLM safeguards, with promising applications in tumor metastasis modeling and precision drug development ...
Aoqi Wang +11 more
wiley +1 more source
T Cell Exhaustion in Cancer Immunotherapy: Heterogeneity, Mechanisms, and Therapeutic Opportunities
Advanced Science, EarlyView.T cell exhaustion limits immunotherapy efficacy. This article delineates its progression from stem‐like to terminally exhausted states, governed by persistent antigen, transcription factors, epigenetics, and metabolism. It maps the exhaustion landscape in the TME and proposes integrated reversal strategies, providing a translational roadmap to overcome
Yang Yu +7 more
wiley +1 more source
Acute Infection and Subsequent Subclinical Reactivation of Herpes Simplex Virus 2 after Vaginal Inoculation of Rhesus Macaques. [PDF]
, 2019 Herpes simplex virus 2 (HSV-2) is a common sexually transmitted infection with a highly variable clinical course. Many infections quickly become subclinical, with episodes of spontaneous virus reactivation.
Burgener, Adam +15 more
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