Results 191 to 200 of about 160,631 (264)

Stress disrupts hippocampal integration of overlapping events and memory inference in humans. [PDF]

open access: yesSci Adv
Schüren KA   +5 more
europepmc   +1 more source

Rewriting Tumor Immunity With Bacterial Membrane Vesicles: A Versatile and Potent Therapeutic Strategy

open access: yesAdvanced NanoBiomed Research, EarlyView.
Bacterial membrane vesicles (BMVs) emerge as promising platforms for cancer immunotherapy owing to their intrinsic adjuvant properties and tunable cargo delivery capabilities. Their ability to modulate the tumor microenvironment, enhance antitumor immune responses, and support personalized therapeutic strategies highlights their growing potential as ...
Md Sifat Rahi   +6 more
wiley   +1 more source

Glutathione‐Responsive Acyl‐Modifications for Targeted RNA Decaging and Prolonged Protein Synthesis

open access: yesAngewandte Chemie, EarlyView.
The self‐immolation of disulfide‐based mRNA modifications in response to endogenous glutathione (GSH) promotes a gradual release of translatable mRNA within the cell, leading to improved nuclease resistance, tunable release properties, and a significant increase (up to 600%) of target protein production over time. This strategy offers an exciting proof
Mary E. Flood   +6 more
wiley   +2 more sources

Nitro Reduction‐Based RNA Control and Ultrafast Release

open access: yesAngewandte Chemie, EarlyView.
A chemical RNA caging–uncaging strategy based on nitro reduction is described. Nitroaryl groups introduced via acylation temporarily block the functions of diverse RNAs in vitro and in living cells. Treatment with a diboronic acid–bipyridine mixture rapidly reduces the nitro groups, releasing RNAs and restoring their activity.
Yiran Zhao   +6 more
wiley   +2 more sources

EBV reactivation and immunoparalysis indicate a harmful immune endotype in sepsis. [PDF]

open access: yesCrit Care
Rosiewicz KS   +19 more
europepmc   +1 more source

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