Results 271 to 280 of about 352,512 (360)

Bioenergetic Materials for Tissue Regeneration: Modulating Metabolism to Promote Cellular Anabolism

Advanced Science, EarlyView.
Bioenergetic materials (BEMs) modulate cellular metabolism to promote tissue regeneration. Their principal mechanisms of action include metabolic substrate supplementation, metabolic enzyme modulation, organelle transfer, electrical current regulation, redox homeostasis modulation, and oxygen tension modulation.
Yuchen He, Yuwen Wang, Jonathan F. Gong, Yiting Lei, Fei Jin, Weihong Zhu, Rocky S. Tuan, Zhong Alan Li   +7 more
wiley   +1 more source

CMV and HHV-6 reactivation in immunocompetent patients hospitalised in the ICU - is it a real problem? A case series and narrative review. [PDF]

Anaesthesiol Intensive Ther
Wieczorek A, Fidler K, Łysenko L.
europepmc   +1 more source

Engineered Allosteric Biosensor for In Situ DNA Glycosylase Detection in Neuroblastoma Risk Stratification and Drug Resistance Monitoring

Advanced Science, EarlyView.
An engineered allosteric biosensor (UUU‐DZ‐tFNA) was developed, in which UDG specifically recognizes and activates a DNAzyme to achieve signal cycle amplification in a sequentially activatable mode. UUU‐DZ‐tFNA achieves in situ UDG detection across multiple biological levels and facilitates risk stratification and drug resistance monitoring of NB ...
Yaqing Lu, Yingyu Zhang, Xianwei Zhang, Mengxin Zhang, Fei Zhang, Jushan Sun, Yahui Yang, Kangbo Liu, Peng Wang, Shuying Luo, Wancun Zhang   +10 more
wiley   +1 more source

Mechanisms and Determinants of CMV Reactivation in Kidney Transplantation. [PDF]

Int J Mol Sci
Naik R, Dabbas W, Veldepenas B, Harvell D, Eshac F, Trivedi M, Minicucci C, Hummel M, Zhang ZJ, Gallon L, Forte E.   +10 more
europepmc   +1 more source

Restores Aβ Clearance by Overcoming PCSK9–LRP1 Dysregulation and TRIB3‐Mediated Autophagy Blockade in Alzheimer's Disease

Advanced Science, EarlyView.
PCSK9 upregulation in cerebrovascular endothelial cells and microglia destabilizes the Aβ transporter LRP1, while TRIB3‐associated autophagy blockade further limits intracellular Aβ degradation. A RAP‐modified tea‐polyphenol nanoparticle co‐delivers siPCSK9 and siTRIB3 to restore LRP1‐mediated Aβ efflux and autophagy‐dependent degradation, reducing Aβ ...
Jie Miao, Jing Wang, Yankun Li, Haipei Zhang, Yanli Zhang, Qingnian Li, Bo Xiao, Wenhu Zhou, Junhong Guo   +8 more
wiley   +1 more source

The human cytomegalovirus chemokine binding protein UL22A is necessary for efficient reactivation from latency in CD34⁺ hematopoietic progenitor cells and humanized mice. [PDF]

J Virol
Turner RL, Diggins NL, Slind L, Mitchell J, Pham AH, Parkins CJ, Perez W, Medica S, Denton M, Andoh TF, Webb GM, Andrade-Vera D, Streblow DN, Caposio P, Hancock MH.   +14 more
europepmc   +1 more source

Degrading GPX4 via Biomimetic Nanoparticle‐Mediated In Situ Synthesis of Deep‐Learning‐Designed Binder‐Degron Chimeras for Prostate Cancer Therapy

Advanced Science, EarlyView.
A deep‐learning‐designed binder is fused to a combinatorial degron to create a binder‐degron chimera (bdC) that recruits the CUL2‐RING ubiquitin ligase complex. Encapsulation in a prostate‐cancer‐targeted, CD47‐camouflaged nanocarrier enables tumor‐specific in situ bdC expression, triggering GPX4 degradation and ferroptosis, thereby establishing a ...
Si‐Han Zhang, Ye An, Na Zeng, Mei‐Cheng Liu, Jian‐Xuan Sun, Xi Gong, Jin‐Zhou Xu, Shao‐Gang Wang, Qi‐Dong Xia   +8 more
wiley   +1 more source

Clinically detected hepatitis B virus reactivation in HBsAg-negative, anti-HBc-positive breast cancer patients receiving systemic therapy without antiviral prophylaxis: a two-centre descriptive cohort and nested case study. [PDF]

Front Oncol
Yapar Toros G, Çeken S, Ocak Duran A, Ateş Ö.   +3 more
europepmc   +1 more source

vGPCR-Mediated ANO1 Modulation of Apoptosis Regulates Lytic KSHV Infection. [PDF]

Viruses
Konakalla AR, Moreno OK, Price SE, Sanchez EL.   +3 more
europepmc   +1 more source

Controlled Atom Transfer Radical Depolymerization

Advanced Science, EarlyView.
Controlled atom transfer radical depolymerization allows for precise, uniform shortening of polymer chains to yield monomers on demand. By tuning catalyst concentration and temperature, this strategy prioritizes deactivation to maintain molecular weight control throughout depolymerization.
Dimitra Mantzara, Richard Whitfield, Glen R. Jones, Nghia P. Truong, Athina Anastasaki   +4 more
wiley   +1 more source