Results 91 to 100 of about 5,518,673 (258)

Unique circulating miRNAome signatures captured with distinct molecular states in Lynch syndrome and sporadic colorectal cancer

Molecular Oncology, EarlyView.
Circulating microRNA profiles distinguish nonmalignant Lynch syndrome from cancer‐associated Lynch syndrome, sporadic colorectal cancer, and healthy controls. Age‐stratified analysis reveals disease‐specific regulatory states, and a six‐miRNA panel shows concordant separation in an independent colorectal tissue cohort.
Ramadhani Salum Chambuso, Md Shohel Ul Islam, Rosa M Xicola, Raj Ramesar, Xavier Llor, Sinclair Steele   +5 more
wiley   +1 more source

Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies

FEBS Open Bio, EarlyView.
We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli, Mohammad Nour Alsamsam, Ugnė Bagdonaitė, Van Truc Vu, Chun‐Jen Huang, Polina Kuzhir, Mindaugas Zaremba, Aurimas Kopūstas, Marijonas Tutkus   +8 more
wiley   +1 more source

Optimal reactive power dispatch in a large power system with AC – DC and FACTS controllers

, 2008
With the increased loading of existing power system, the problem of voltage stability and voltage collapse has become a major concern in power system planning and operation.
Thukaram, D, Yesuratnam, G
core  

Passivity-based harmonic control through series/parallel damping of an H-bridge rectifier [PDF]

, 2007
Nowadays the H-bridge is one of the preferred solutions to connect DC loads or distributed sources to the single-phase grid. The control aims are: sinusoidal grid current with unity power factor and optimal DC voltage regulation capability.
Liserre, M., Vito G. Monopoli, Martijn M.J. de Vries, Kransse, M. J., Monopoli, V. G., Liserre, M.,, Marco J. Kransse, De Vries, M. M. J., Scherpen, J. M. A., LISERRE, Marco, Scherpen, J. M. A.,, Monopoli, V. G.,, Marco Liserre, Kransse, M. J.,, MONOPOLI, Vito Giuseppe, Jacquelien M.A. Scherpen, De Vries, M. M. J.,   +16 more
core   +2 more sources

Optimizing photoactivation of PA‐mCherry for optical pooled CRISPR screens

FEBS Open Bio, EarlyView.
Photoactivatable PA‐mCherry finds widespread use to optically tag individual cells. However, confocal 405 nm UV laser‐scanning (normal scan) is much less efficient than widefield UV illumination, limiting the use of PA‐mCherry on confocal instruments. We remedy this limitation by reporting that rapid and repeated confocal scanning with a low‐intensity,
Sravasti Mukherjee, Giulia Zanetti, Bram van den Broek, Kees Jalink   +3 more
wiley   +1 more source

Multistrategy Learning of Adaptive Reactive Controllers

, 1997
Reactive controllers has been widely used in mobile robots since they are able to achieve successful performance in real-time. However, the configuration of a reactive controller depends highly on the operating conditions of the robot and the environment;
Ashwin Ram, Juan Carlos Santamaria
core   +1 more source

UiO‐66 metal–organic frameworks in biomedicine: From structural tunability to bioimaging, photodiagnostics, and photodynamic cancer therapy

FEBS Open Bio, EarlyView.
UiO‐66(Zr) metal–organic frameworks are chemically stable, biocompatible, and highly tunable nanomaterials. Their modular structure enables controlled drug delivery, multimodal bioimaging, and light‐activated photodynamic therapy, supporting integrated diagnostic and therapeutic (theranostic) applications in cancer and biomedical research.
Veronika Huntošová, Grigorii Rakhalskii, Miroslav Almáši   +2 more
wiley   +1 more source

A study of reactive power marginal price in electricity market

, 2001
Developing an accurate and feasible method for reactive power pricing is significant in the electricity market. The reactive power price cannot be obtained accurately by conventional optimal power flow models which usually ignore the production cost of ...
Felix F. Wu, Z.X. Han, Y. Dai, Y.X. Ni, Ni, YX, Wu, FF, F.S. Wen, Dai, Y, Shen, CM, C.M. Shen, Wen, FS, Han, ZX   +11 more
core   +1 more source

Guiding AlphaFold to predict how Munc13‐1 opens Syntaxin‐1

FEBS Open Bio, EarlyView.
The syntaxin‐1 Habc‐domain (orange), linker (pink) and SNARE motif (yellow) form a closed conformation that binds to Munc18‐1 (violet) and is opened by the Munc13‐1 MUN domain (cyan) to form the SNARE complex that triggers neurotransmitter release.
Madhurima Chattopadhyay, Junjie Xu, Josep Rizo   +2 more
wiley   +1 more source

Treatment with KCL‐286, a first‐in‐class retinoic acid receptor‐β (RARβ) agonist, ameliorates neuronal DNA damage and inflammation in a mouse model of Alzheimer's disease

FEBS Open Bio, EarlyView.
Repair of neuronal DNA damage in Alzheimer's disease by KCL‐286. (A) Amyloid‐β oligomers and plaques impair neuronal DNA repair pathways, leading to DNA double‐strand breaks and glial activation. (B) KCL‐286 activates RARβ/RXR signalling via retinoic acid response elements (RAREs), associated with increased BRCA1 expression, enhanced DNA repair and ...
Natasha Hill, Hassan Yousef Othman AlMuallim, Elouisa Maddock, Carl Hobbs, Earl Clarke, Maria B. Goncalves, Jonathan P. T. Corcoran   +6 more
wiley   +1 more source