Results 41 to 50 of about 407,788 (261)

Awake reactivation is not a uniform process

Trends in Cognitive Sciences
Memories are consolidated during restful wakefulness, but the mechanisms underlying this process are poorly understood. We argue that wakeful reactivation is not monolithic: it encompasses non-conscious and conscious processes with varying levels of elaboration and diverging consequences.
Tal, Amir, Schechtman, Eitan
openaire   +3 more sources

ABL kinase‐dependent phosphorylation of SH proteins promotes their direct interaction with CRK family SH2 domains

FEBS Letters, EarlyView.
CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens, Brendan W. Chandler, Anna M. Schmoker, Jaye L. Weinert, Charlotte A. Kearns, Warren T. Yacawych, Amila Šemić, Alicia M. Ebert, Bryan A. Ballif   +8 more
wiley   +1 more source

PP-EPDM thermoplastic vulcanisates (TPVs) by electron induced reactive processing

eXPRESS Polymer Letters, 2009
Reactive processing combines melt mixing process and chemical reaction simultaneously. TPVs are produced by such reactive processing. Polymer modification with high energy electrons is based on generation of excited atoms or molecules and ions for ...
doaj   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

OPTIMISATION OF PROCESS PARAMETER CONDITIONS FOR BIODIESEL PRODUCTION BY REACTIVE EXTRACTION OF JATROPHA SEEDS [PDF]

Journal of Engineering Science and Technology, 2017
Biodiesel can be produced by reactive extraction of jatropha seeds to reduce the cost and processing time associated with conventional methods. In this study, the relationship between various parameters of reactive extraction of jatropha seeds is ...
MUHAMMAD DANI SUPARDAN, FAHRIZAL, RYAN MOULANA, DESI SAFRIDA, SATRIANA, WAN AIDA WAN MUSTAPHA   +5 more
doaj  

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Preparation of Maleic Anhydride Grafted Poly(trimethylene terephthalate) (PTT-g-MA) by Reactive Extrusion Processing

Journal of Manufacturing and Materials Processing, 2019
Maleic anhydride (MA) grafted with poly(trimethylene terephthalate) (PTT)—abbreviated as PTT-g-MA—can be used as a compatibilizing agent to improve the compatibility and dispersion of nanofillers and a dispersed polymer phase into PTT matrix.
Natália F. Braga, Henrique M. Zaggo, Thaís L. A. Montanheiro, Fabio R. Passador   +3 more
doaj   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Internalization and presentation of myelin antigens by the brain endothelium guides antigen-specific T cell migration

eLife, 2016
Trafficking of myelin-reactive CD4+ T-cells across the brain endothelium, an essential step in the pathogenesis of multiple sclerosis (MS), is suggested to be an antigen-specific process, yet which cells provide this signal is unknown.
Melissa A Lopes Pinheiro, Alwin Kamermans, Juan J Garcia-Vallejo, Bert van het Hof, Laura Wierts, Tom O'Toole, Daniël Boeve, Marleen Verstege, Susanne MA van der Pol, Yvette van Kooyk, Helga E de Vries, Wendy WJ Unger   +11 more
doaj   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source