Results 41 to 50 of about 3,938,090 (292)

Safety of Daprodustat for the Treatment of Chronic Kidney Disease Anemia: Final Analysis of a Multicenter Postmarketing Surveillance Study in Japan

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Introduction This final analysis of a multicenter, prospective postmarketing surveillance study evaluated the safety of daprodustat in patients with chronic kidney disease anemia in routine clinical practice in Japan. Methods Patients who initiated daprodustat between September 2020 and July 2022 were registered.
Tadao Akizawa, Kyomi Kanaya, Kiyomi Aizawa, Masanori Onoki, Hirofumi Ozeki, Kazuko Suzuki, Ai Hayashi, Tomohiko Asamura   +7 more
wiley   +1 more source

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

FEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes, Jan Brysch, Carmen Gelze, Lilli Meier, Daniel Kümmel   +4 more
wiley   +1 more source

A Predictive-reactive Approach for JSP with Uncertain Processing Times [PDF]

, 2010
The paper is supported by the Asia-Link project funded by the European Commission (CN/ASIA-LINK/024 (109093)), the National Natural Science Foundation of China (50705076, 50705077), and the National Hi-Tech R&D Program of China (2007AA04Z187)JSP with ...
NIU, Ganggang, ROUCOULES, Lionel, LAFON, Pascal, SUN, Shudong   +3 more
core  

Internalization and presentation of myelin antigens by the brain endothelium guides antigen-specific T cell migration

eLife, 2016
Trafficking of myelin-reactive CD4+ T-cells across the brain endothelium, an essential step in the pathogenesis of multiple sclerosis (MS), is suggested to be an antigen-specific process, yet which cells provide this signal is unknown.
Melissa A Lopes Pinheiro, Alwin Kamermans, Juan J Garcia-Vallejo, Bert van het Hof, Laura Wierts, Tom O'Toole, Daniël Boeve, Marleen Verstege, Susanne MA van der Pol, Yvette van Kooyk, Helga E de Vries, Wendy WJ Unger   +11 more
doaj   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

A Deep Neural Network as a Strategy for Optimal Sizing and Location of Reactive Compensation Considering Power Consumption Uncertainties

Energies, 2022
This research proposes a methodology for the optimal location and sizing of reactive compensation in an electrical transmission system through a deep neural network (DNN) by considering the smallest cost for compensation. An electrical power system (EPS)
Manuel Jaramillo, Diego Carrión, Jorge Muñoz   +2 more
doaj   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Feasibility of Batch Reactive Distillation with Equilibrium-Limited Consecutive Reactions in Rectifier, Stripper, or Middle-Vessel Column. [PDF]

, 2011
A general overall feasibility methodology of batch reactive distillation of multireaction systems is developed to study all the possible configurations of batch reactive distillation.
Lelkes, Zoltan, T. Lukács, Stéger, Csaba, C. Stéger, Rev, Endre, Meyer, Michel, Lukacs, Timea, Z. Lelkes, E. Rév, M. Meyer   +9 more
core   +1 more source

PP-EPDM thermoplastic vulcanisates (TPVs) by electron induced reactive processing

eXPRESS Polymer Letters, 2009
Reactive processing combines melt mixing process and chemical reaction simultaneously. TPVs are produced by such reactive processing. Polymer modification with high energy electrons is based on generation of excited atoms or molecules and ions for ...
doaj   +1 more source