Results 171 to 180 of about 1,362,093 (292)

Read-Across Structural Analysis of PFAS Acute Oral Toxicity in Rats Powered by the Isalos Analytics Platform's Automated Machine Learning. [PDF]

Toxics
Theodori A, Papavasileiou KD, Tsoumanis A, Melagraki G, Afantitis A.   +4 more
europepmc   +1 more source

An Integrated Approach to Testing and Assessment to Support Grouping and Read-Across of Nanomaterials After Inhalation Exposure. [PDF]

Appl In Vitro Toxicol, 2021
Braakhuis HM, Murphy F, Ma-Hock L, Dekkers S, Keller J, Oomen AG, Stone V.   +6 more
europepmc   +1 more source

Rapid screening of staphylokinase protein variants using an unpurified cell‐free expression system

FEBS Open Bio, EarlyView.
An unpurified cell‐free protein synthesis (CFPS) platform enables rapid functional screening of staphylokinase variants. Direct plasminogen‐activation assays performed in microplate format provide real‐time activity readouts, allowing rapid identification and ranking of variants with improved or reduced fibrinolytic activity without protein ...
Maria Tomková, Veronika Hovanová, Jiri Damborsky, Erik Sedlák   +3 more
wiley   +1 more source

What does "success" look like in compliance check decisions by the European Chemicals Agency? The curious cases of accepted read-across adaptations. [PDF]

ALTEX
Roe HM, Tsai HD, Ball N, Oware KD, Han G, Chiu WA, Rusyn I.   +6 more
europepmc   +1 more source

Evolutionarily divergent DUF4465 domains have a common vitamin B12‐binding function

FEBS Open Bio, EarlyView.
We show that DUF4465 family proteins, widespread across bacteria from gut microbiomes, hydrothermal vents, and soil, share a common vitamin B12‐binding function. These augmented β‐jellyroll proteins bind vitamin B12 via extended loops. Our findings establish sequence‐diverse DUF4465 proteins as a widespread class of B12‐binding proteins, highlighting ...
Charlea Clarke, Michal Banasik, Rokas Juodeikis, Martin J. Warren, Richard W. Pickersgill   +4 more
wiley   +1 more source

A systematic analysis of read-across adaptations in testing proposal evaluations by the European Chemicals Agency. [PDF]

ALTEX
Roe HM, Tsai HD, Ball N, Wright FA, Chiu WA, Rusyn I.   +5 more
europepmc   +1 more source

Systemic dysregulation of apolipoproteins in amyotrophic lateral sclerosis serum

FEBS Open Bio, EarlyView.
Amyotrophic lateral sclerosis (ALS) is a fatal disease that damages motor neurons. This study found that people with ALS show significant changes in blood fats and the proteins that carry them. Several apolipoproteins were higher, lipid balances were altered, and normal protein–lipid relationships were disrupted.
Finula I. Isik, Russell Pickford, Hannah C. Timmins, Olivier Piguet, Glenda M. Halliday, Matthew C. Kiernan, Woojin Scott Kim   +6 more
wiley   +1 more source

Molecular similarity in chemical informatics and predictive toxicity modeling: from quantitative read-across (q-RA) to quantitative read-across structure-activity relationship (q-RASAR) with the application of machine learning. [PDF]

Crit Rev Toxicol
Banerjee A, Kar S, Roy K, Patlewicz G, Charest N, Benfenati E, Cronin MTD.   +6 more
europepmc   +1 more source

Repeat-dose toxicity prediction with Generalized Read-Across (GenRA) using targeted transcriptomic data: A proof-of-concept case study. [PDF]

Comput Toxicol, 2021
Tate T, Wambaugh J, Patlewicz G, Shah I.
europepmc   +1 more source

(Q)SARs to Predict Environmental Toxicities: Current Status and Future Needs [PDF]

The current state of the art of (Quantitative) Structure-Activity Relationships ((Q)SARs) to predict environmental toxicity is assessed along with recommendations to develop these models further.
Cronin, MTD
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