Results 201 to 210 of about 1,362,093 (292)

Mutant NPM1 in Acute Myeloid Leukemia Initiation and Maintenance

Aging and Cancer, EarlyView.
NPM1 mutations drive acute myeloid leukemia by acting as neomorphic transcriptional regulators that cooperate with Menin–MLL and XPO1 to sustain HOX/MEIS1 expression and block differentiation. Targeting these mutant‐specific transcriptional dependencies provides a rational therapeutic strategy for NPM1‐mutated AML.
Yanan Jiang, Zhong Fan, Runmeng Liu, Xiaotian Zhang   +3 more
wiley   +1 more source

Development of a Robust Read-Across Model for the Prediction of Biological Potency of Novel Peroxisome Proliferator-Activated Receptor Delta Agonists. [PDF]

Int J Mol Sci
Antoniou M, Papavasileiou KD, Melagraki G, Dondero F, Lynch I, Afantitis A.   +5 more
europepmc   +1 more source

Critical Review of Read-Across Potential in Testing for Endocrine-Related Effects in Vertebrate Ecological Receptors. [PDF]

Environ Toxicol Chem, 2020
McArdle ME, Freeman EL, Staveley JP, Ortego LS, Coady KK, Weltje L, Weyers A, Wheeler JR, Bone AJ.   +8 more
europepmc   +1 more source

Skills framework for 3 to 19-year-olds in Wales = Fframwaith sgiliau ar gyfer dysgwyr 3 i 19 oed yng Nghymru [PDF]

, 2008

core  

Long‐Term Follow‐Up of Chemotherapy‐Associated Biological Aging in Women With Early Breast Cancer

Aging and Cancer, EarlyView.
Women threated with adjuvant chemotherapy for early breast cancer have sustained long‐term increase in p16INK4a,, a robust marker of cell senescence, suggesting a chemotherapy‐associated age acceleration. p16INK4a as well as other biomarkers may identify patients at greatest risk for senescence‐related diseases of aging.
Hyman B. Muss, Alexis C. Wardell, Allison M. Deal, Kirsten A. Nyrop, Allison Ross, Yara G. Abdou, Jeffrey D. Aldrich, Lisa A. Cary, E. Claire Dees, Katherine E. Reeder‐Hayes, Emily M. Ray, Natalia Mitin, Denis Tsygankov   +12 more
wiley   +1 more source

Multi-omics bioactivity profile-based chemical grouping and read-across: a case study with Daphnia magna and azo dyes. [PDF]

Arch Toxicol
Gruszczynska H, Barnett RE, Lloyd GR, Weber RJM, Lawson TN, Zhou J, Sostare E, Colbourne JK, Viant MR.   +8 more
europepmc   +1 more source

Assessment of the predictive capacity of a physiologically based kinetic model using a read-across approach.

Comput Toxicol, 2021
Paini A, Worth A, Kulkarni S, Ebbrell D, Madden J.   +4 more
europepmc   +1 more source

Tracking Motor Progression and Device‐Aided Therapy Eligibility in Parkinson's Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To characterise the progression of motor symptoms and identify eligibility for device‐aided therapies in Parkinson's disease, using both the 5‐2‐1 criteria and a refined clinical definition, while examining differences across genetic subgroups.
David Ledingham, Sahana Sathyanarayana, Charlotte B. Stewart, Robyn Iredale, Victoria Foster, Debra Galley, Mark Baker, Nicola Pavese   +7 more
wiley   +1 more source

Mechanism-Driven Read-Across of Chemical Hepatotoxicants Based on Chemical Structures and Biological Data. [PDF]

Toxicol Sci, 2020
Zhao L, Russo DP, Wang W, Aleksunes LM, Zhu H.   +4 more
europepmc   +1 more source

The McCance Brain Care Score and Mortality: Evidence From a Large‐Scale Population‐Based Cohort

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objectives This study aimed to examine the relationship between the McCance Brain Care Score (BCS) and mortality in the general population. Methods We conducted a prospective, population‐based cohort study using data from the UK Biobank. Participants with complete data enabling calculation of BCS and full mortality information were included ...
Zhiqiang Xu, Xiaoxiao Wang, Nan Li
wiley   +1 more source