Results 171 to 180 of about 4,178,128 (285)

A systematic analysis of read-across adaptations in testing proposal evaluations by the European Chemicals Agency. [PDF]

ALTEX
Roe HM, Tsai HD, Ball N, Wright FA, Chiu WA, Rusyn I.   +5 more
europepmc   +1 more source

Reading visual narratives across cultures

, 2021
In this book, Cohn starts by questioning the widespread assumption that the meaning of sequential images is transparent and universally comprehended. He calls this idea Sequential Image Transparency Assumption (SITA) and suggests that it is probably derived from the intuitions of adults who are familiar with visual narratives.
openaire   +1 more source

Systemic dysregulation of apolipoproteins in amyotrophic lateral sclerosis serum

FEBS Open Bio, EarlyView.
Amyotrophic lateral sclerosis (ALS) is a fatal disease that damages motor neurons. This study found that people with ALS show significant changes in blood fats and the proteins that carry them. Several apolipoproteins were higher, lipid balances were altered, and normal protein–lipid relationships were disrupted.
Finula I. Isik, Russell Pickford, Hannah C. Timmins, Olivier Piguet, Glenda M. Halliday, Matthew C. Kiernan, Woojin Scott Kim   +6 more
wiley   +1 more source

Molecular similarity in chemical informatics and predictive toxicity modeling: from quantitative read-across (q-RA) to quantitative read-across structure-activity relationship (q-RASAR) with the application of machine learning. [PDF]

Crit Rev Toxicol
Banerjee A, Kar S, Roy K, Patlewicz G, Charest N, Benfenati E, Cronin MTD.   +6 more
europepmc   +1 more source

Repeat-dose toxicity prediction with Generalized Read-Across (GenRA) using targeted transcriptomic data: A proof-of-concept case study. [PDF]

Comput Toxicol, 2021
Tate T, Wambaugh J, Patlewicz G, Shah I.
europepmc   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Read-Across of Biotransformation Potential between Activated Sludge and the Terrestrial Environment: Toward Making It Practical and Plausible. [PDF]

Environ Sci Technol
Coll C, Screpanti C, Hafner J, Zhang K, Fenner K.   +4 more
europepmc   +1 more source

Application of grouping and read-across for the evaluation of parabens of different chain lengths with a particular focus on endocrine properties. [PDF]

Arch Toxicol, 2021
Fayyaz S, Kreiling R, Sauer UG.
europepmc   +1 more source

Why human connection is the true metric of research success

FEBS Open Bio, EarlyView.
Human‐centred mentorship can be shaped by mentor attributes, actions, intrinsic drive and career ambition. Drawing on reflections across Singapore and France, as well as workshop insights from FEBS‐IUBMB ENABLE 2024, this article shows that human‐centred mentorship creates the conditions for sustainable growth, well‐being and retention in research ...
Timothy Lin Yun Tan, Mattias Wei Ren Kon, Xavier Coumoul, Fun Man Fung   +3 more
wiley   +1 more source

A systematic analysis of read-across within REACH registration dossiers. [PDF]

Comput Toxicol
Patlewicz G, Karamertzanis P, Friedman KP, Sannicola M, Shah I.   +4 more
europepmc   +1 more source