Results 11 to 20 of about 862,407 (43)

The RNA m6A reader YTHDF2 maintains oncogene expression and is a targetable dependency in glioblastoma stem cells.

Cancer Discovery, 2020
Glioblastoma is a universally lethal cancer driven by glioblastoma stem cells (GSCs). Here, we interrogated N6-methyladenosine (m6A) mRNA modifications in GSCs by methyl RNA-immunoprecipitation followed by sequencing (meRIP-seq) and transcriptome ...
Deobrat Dixit, B. Prager, Ryan C. Gimple, Hui Xian Poh, Yang Wang, Qiulian Wu, Zhixin Qiu, Reilly L. Kidwell, Leo J. Y. Kim, Qi Xie, Kristoffer Vitting-Seerup, S. Bhargava, Zhen Dong, Li Jiang, Zhe Zhu, P. Hamerlik, S. Jaffrey, Jing Crystal Zhao, Xiuxing Wang, J. Rich   +19 more
semanticscholar   +1 more source

RNA N6-methyladenosine reader IGF2BP3 regulates cell cycle and angiogenesis in colon cancer

Journal of experimental & clinical cancer research : CR, 2020
N6-Methyladenosine (m6A) modification has been implicated in multiple processes for colon cancer development. IGF2BP3 was a newly reported m6A reader, whereas its role in colon cancer remains unclear.
Zhou Yang, Tingfeng Wang, Dejun Wu, Zhi-jun Min, Jingyun Tan, Bo Yu   +5 more
semanticscholar   +1 more source

5-methylcytosine promotes mRNA export — NSUN2 as the methyltransferase and ALYREF as an m5C reader

Cell Research, 2017
5-methylcytosine (m5C) is a post-transcriptional RNA modification identified in both stable and highly abundant tRNAs and rRNAs, and in mRNAs. However, its regulatory role in mRNA metabolism is still largely unknown.
Xin Yang, Ying Yang, Bao-Fa Sun, Yu-Sheng Chen, Jiawei Xu, Weiyi Lai, Ang Li, Xing Wang, Devi Prasad Bhattarai, Wen Xiao, Huiying Sun, Qin Zhu, Hai-Li Ma, Samir Adhikari, Min Sun, Ya-Juan Hao, Bing Zhang, Chunmin Huang, Niu Huang, Guibin Jiang, Yong‐Liang Zhao, Hailin Wang, Ying-Pu Sun, Yun-Gui Yang   +23 more
semanticscholar   +1 more source

An oncopeptide regulates m6A recognition by the m6A reader IGF2BP1 and tumorigenesis

Nature Communications, 2020
N6-methyladenosine (m6A) is the most prevalent modification in eukaryotic RNAs. The biological importance of m6A relies on m6A readers, which control mRNA fate and function.
Song Zhu, Jizhong Wang, De Chen, Yutian He, Nan Meng, Min Chen, R. Lu, Xin-Hui Chen, Xiao-Lan Zhang, Guang-Rong Yan   +9 more
semanticscholar   +1 more source

Nuclear m6A reader YTHDC1 regulates alternative polyadenylation and splicing during mouse oocyte development

PLoS Genetics, 2018
The N6-methyladenosine (m6A) modification is the most prevalent internal RNA modification in eukaryotes. The majority of m6A sites are found in the last exon and 3’ UTRs.
Seth D. Kasowitz, Jun Ma, S. Anderson, N. Leu, Yang Xu, B. Gregory, R. Schultz, R. Schultz, P. Wang   +8 more
semanticscholar   +1 more source

Long noncoding RNA GAS5 inhibits progression of colorectal cancer by interacting with and triggering YAP phosphorylation and degradation and is negatively regulated by the m6A reader YTHDF3

Molecular Cancer, 2019
YAP activation is crucial for cancer development including colorectal cancer (CRC). Nevertheless, it remains unclear whether N6-Methyladenosine (m6A) modified transcripts of long noncoding RNAs (lncRNAs) can regulate YAP activation in cancer progression.
Wen Ni, Su Yao, Yunxia Zhou, Yuan-yuan Liu, Piao Huang, Ai-jun Zhou, Jingwen Liu, Li-Heng Che, Jian-Ming Li   +8 more
semanticscholar   +1 more source

Context-dependent functional compensation between Ythdf m6A reader proteins

Genes & Development, 2020
Here, Lasman et al. sought to understand the role of three homologous m6A-binding proteins (Ythdf1, Ythdf2, and Ythdf3) and systematically knocked out the Mettl3 writer, each of the Ythdf readers, and the three readers together (triple-KO).
Lior Lasman, V. Krupalnik, Sergey V. Viukov, Nofar Mor, Alejandro Aguilera-Castrejon, Dan Schneir, Jonathan Bayerl, Orel Mizrahi, Shani Peles, Shadi Tawil, S. Sathe, A. Nachshon, Tom Shani, Mirie Zerbib, Itay Kilimnik, S. Aigner, Archana Shankar, Jasmine R. Mueller, Schraga Schwartz, Noam Stern-Ginossar, Gene W. Yeo, Shay Geula, Noa Novershtern, J. Hanna   +23 more
semanticscholar   +1 more source

Optimal Channel Estimation for Reciprocity-Based Backscattering With a Full-Duplex MIMO Reader [PDF]

IEEE Transactions on Signal Processing, 2019
Backscatter communication (BSC) technology can enable ubiquitous deployment of low-cost sustainable wireless devices. In this paper, we investigate the efficacy of a full-duplex multiple-input-multiple-output reader for enhancing the limited ...
Deepak Mishra, E. Larsson
semanticscholar   +1 more source

BET Epigenetic Reader Proteins in Cardiovascular Transcriptional Programs.

Circulation Research, 2020
Epigenetic mechanisms involve the placing (writing) or removal (erasing) of histone modifications that allow heterochromatin to transition to the open, activated euchromatin state necessary for transcription.
P. Borck, Lian‐Wang Guo, J. Plutzky
semanticscholar   +1 more source

IGF2BP2 regulates DANCR by serving as an N6-methyladenosine reader

Cell Death and Differentiation, 2019
The major function of Insulin-like growth factor 2 mRNA-binding protein 2 (IGF2BP2) is to regulate cell metabolism. However, emerging evidence indicates that IGF2BP2 plays a role in cancer, but the underlying mechanism is largely unknown.
Xiaoge Hu, Wan-Xin Peng, Huaixiang Zhou, Jiahong Jiang, Xinchun Zhou, Dongsheng Huang, Y. Mo, Liu Yang   +7 more
semanticscholar   +1 more source