Results 11 to 20 of about 849,822 (42)

Effects of the reader's schema at different points in time

, 1979
In two experiments, subjects were instructed to take a distinctive point of view while reading and recalling a story. Perspectives assigned before reading, shortly after reading, and long after reading all had substantial effects on recall.
Richard C. Anderson, J. Pichert, Larry L. Shirey   +2 more
semanticscholar   +1 more source

An oncopeptide regulates m6A recognition by the m6A reader IGF2BP1 and tumorigenesis

Nature Communications, 2020
N6-methyladenosine (m6A) is the most prevalent modification in eukaryotic RNAs. The biological importance of m6A relies on m6A readers, which control mRNA fate and function.
Song Zhu, Jizhong Wang, De Chen, Yutian He, Nan Meng, Min Chen, R. Lu, Xin-Hui Chen, Xiao-Lan Zhang, Guang-Rong Yan   +9 more
semanticscholar   +1 more source

Nuclear m6A reader YTHDC1 regulates alternative polyadenylation and splicing during mouse oocyte development

PLoS Genetics, 2018
The N6-methyladenosine (m6A) modification is the most prevalent internal RNA modification in eukaryotes. The majority of m6A sites are found in the last exon and 3’ UTRs.
Seth D. Kasowitz, Jun Ma, S. Anderson, N. Leu, Yang Xu, B. Gregory, R. Schultz, R. Schultz, P. Wang   +8 more
semanticscholar   +1 more source

Context-dependent functional compensation between Ythdf m6A reader proteins

Genes & Development, 2020
Here, Lasman et al. sought to understand the role of three homologous m6A-binding proteins (Ythdf1, Ythdf2, and Ythdf3) and systematically knocked out the Mettl3 writer, each of the Ythdf readers, and the three readers together (triple-KO).
Lior Lasman, V. Krupalnik, Sergey V. Viukov, Nofar Mor, Alejandro Aguilera-Castrejon, Dan Schneir, Jonathan Bayerl, Orel Mizrahi, Shani Peles, Shadi Tawil, S. Sathe, A. Nachshon, Tom Shani, Mirie Zerbib, Itay Kilimnik, S. Aigner, Archana Shankar, Jasmine R. Mueller, Schraga Schwartz, Noam Stern-Ginossar, Gene W. Yeo, Shay Geula, Noa Novershtern, J. Hanna   +23 more
semanticscholar   +1 more source

BET Epigenetic Reader Proteins in Cardiovascular Transcriptional Programs.

Circulation Research, 2020
Epigenetic mechanisms involve the placing (writing) or removal (erasing) of histone modifications that allow heterochromatin to transition to the open, activated euchromatin state necessary for transcription.
P. Borck, Lian‐Wang Guo, J. Plutzky
semanticscholar   +1 more source

Long noncoding RNA GAS5 inhibits progression of colorectal cancer by interacting with and triggering YAP phosphorylation and degradation and is negatively regulated by the m6A reader YTHDF3

Molecular Cancer, 2019
YAP activation is crucial for cancer development including colorectal cancer (CRC). Nevertheless, it remains unclear whether N6-Methyladenosine (m6A) modified transcripts of long noncoding RNAs (lncRNAs) can regulate YAP activation in cancer progression.
Wen Ni, Su Yao, Yunxia Zhou, Yuan-yuan Liu, Piao Huang, Ai-jun Zhou, Jingwen Liu, Li-Heng Che, Jian-Ming Li   +8 more
semanticscholar   +1 more source

Optimal Channel Estimation for Reciprocity-Based Backscattering With a Full-Duplex MIMO Reader [PDF]

IEEE Transactions on Signal Processing, 2019
Backscatter communication (BSC) technology can enable ubiquitous deployment of low-cost sustainable wireless devices. In this paper, we investigate the efficacy of a full-duplex multiple-input-multiple-output reader for enhancing the limited ...
Deepak Mishra, E. Larsson
semanticscholar   +1 more source

5-methylcytosine promotes mRNA export — NSUN2 as the methyltransferase and ALYREF as an m5C reader

Cell Research, 2017
5-methylcytosine (m5C) is a post-transcriptional RNA modification identified in both stable and highly abundant tRNAs and rRNAs, and in mRNAs. However, its regulatory role in mRNA metabolism is still largely unknown.
Xin Yang, Ying Yang, Bao-Fa Sun, Yu-Sheng Chen, Jiawei Xu, Weiyi Lai, Ang Li, Xing Wang, Devi Prasad Bhattarai, Wen Xiao, Huiying Sun, Qin Zhu, Hai-Li Ma, Samir Adhikari, Min Sun, Ya-Juan Hao, Bing Zhang, Chunmin Huang, Niu Huang, Guibin Jiang, Yong‐Liang Zhao, Hailin Wang, Ying-Pu Sun, Yun‐Gui Yang   +23 more
semanticscholar   +1 more source

A novel m6A reader Prrc2a controls oligodendroglial specification and myelination

Cell Research, 2018
While N6-methyladenosine (m6A), the most abundant internal modification in eukaryotic mRNA, is linked to cell differentiation and tissue development, the biological significance of m6A modification in mammalian glial development remains unknown. Here, we
R. Wu, Ang Li, Baofa Sun, Jian-guang Sun, Jinhua Zhang, Ting Zhang, Yusheng Chen, Yujie Xiao, Yuhao Gao, Qingyang Zhang, Jun Ma, Xin Yang, Yajin Liao, Wei-Yi Lai, Xiao-Xue Qi, Shukun Wang, Yousheng Shu, Hailin Wang, Fengchao Wang, Yun‐Gui Yang, Zengqiang Yuan   +20 more
semanticscholar   +1 more source

R3: Reinforced Ranker-Reader for Open-Domain Question Answering

AAAI Conference on Artificial Intelligence, 2018
In recent years researchers have achieved considerable success applying neural network methods to question answering (QA). These approaches have achieved state of the art results in simplified closed-domain settings such as the SQuAD (Rajpurkar et al.
Shuohang Wang, Mo Yu, Xiaoxiao Guo, Zhiguo Wang, Tim Klinger, Wei Zhang, Shiyu Chang, G. Tesauro, Bowen Zhou, Jing Jiang   +9 more
semanticscholar   +1 more source