Results 101 to 110 of about 534,792 (320)

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

open access: yesMolecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat   +8 more
wiley   +1 more source

Kryminalny teatr teorii Normana Hollanda

open access: yesAnnales Universitatis Paedagogicae Cracoviensis. Studia Poetica, 2019
Artykuł skupia się na Death in a Delphi Seminar: A Postmodern Mystery (1995) Normana N. Hollanda oraz na relacjach między tą powieścią i Hollandowską wersją reader-response theory.
Anna Skubaczewska-Pniewska
doaj   +1 more source

Targeting p38α in cancer: challenges, opportunities, and emerging strategies

open access: yesMolecular Oncology, EarlyView.
p38α normally regulates cellular stress responses and homeostasis and suppresses malignant transformation. In cancer, however, p38α is co‐opted to drive context‐dependent proliferation and dissemination. p38α also supports key functions in cells of the tumor microenvironment, including fibroblasts, myeloid cells, and T lymphocytes.
Angel R. Nebreda
wiley   +1 more source

НОРМАН Н. ГОЛЛАНД. ЄДНІСТЬ ІДЕНТИЧНІСТЬ ТЕКСТ Я-САМ

open access: yesСинопсис: текст, контекст, медіа, 2014
Переклад із англійської та коментарі Людмили Анісімової   Перекладено за виданням: Norman N. Holland. UNITY IDENTITY TEXT SELF // Reader-response criticism: From Formalism to Post-Structuralism / Ed. Jane P. Tompkins.
Liudmyla Anisimova
doaj  

Can Machines Read (Literature)?

open access: yesUmanistica Digitale, 2019
In this essay, we reflect on distant reading as one of the various takes on reading that currently prevail in literary scholarship as well as the teaching of literature.
Mike Kestemont, Luc Herman
doaj   +1 more source

\u3cem\u3eThe Chronicles of Narnia\u3c/em\u3e, and How C.S. Lewis Created Christian Fantasy Fiction [PDF]

open access: yes, 2015
C.S. Lewis was a pioneer in combining the ideas of fantasy and Christian literature, before the fantasy genre alone was even acknowledged. Christian fantasy fiction, as a fiction sub-genre, can be identified as a piece of fiction with fantastical ...
Callow, Amanda
core   +1 more source

Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer

open access: yesMolecular Oncology, EarlyView.
PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta   +10 more
wiley   +1 more source

Interpreting texts and the matter of context: Examples from the Book of Ruth

open access: yesVerbum et Ecclesia, 2019
This article aims to explore the matter of context in biblical exegesis and interpretation. Several exegetical approaches are discussed, namely, text-immanent, intertextual comparison, reader-response criticism, which is subdivided into feminist and ...
Gerda de Villiers
doaj   +1 more source

Consciousness Duplication And Our Capacity To Learn From Literary Fictions [PDF]

open access: yes, 2004
Many of us share a strong intuition that fictional literature possesses cognitive value in the sense that it has the capacity to expand and/or clarify our knowledge or understanding of the world.
Mitchell, Allison
core  

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

open access: yesMolecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

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