Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder +10 more
wiley +1 more source
Extending the Dialogue: Responding to Indonesian Multicultural Children’s Literature Cap Go Meh
Journal of Language and LiteratureCap Go Meh is an Indonesian picture book with interreligious and multiethnic themes and has been translated to English and been awarded for promoting multiculturalism. Studies that focus on reader response to interreligious theme of children’s literature
Tati Lathipatud Durriyah, Sofie Dewayani
doaj +1 more source
Reader Response: Clinical Subgroups and Factors Associated With Progression in Patients With Inclusion Body Myositis. [PDF]
Neurology, 2023 Stenzel W, Goebel HH, Kleefeld F.
europepmc +1 more source
MITF maintains genome stability in nonmelanocyte lineages
Molecular Oncology, EarlyView.MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir +13 more
wiley +1 more source
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
Nurturing EFL Preservice Teachers’ Literary Competence Through Picturebooks
Profile: Issues in Teachers' Professional DevelopmentThis study investigates the development of literary competence in 12 EFL preservice teachers participating in a literature course in Santiago (Chile). The research employs content analysis to identify diverse literary competences within the participants.
Gabriel Romero-Karlsson, Malba Barahona
doaj +1 more source
The Construction of the Enemy City in the Hebrew Bible: A Case of Thirdspacing [PDF]
University of Bucharest Review. Literary and Cultural Studies Series, 2016 Scholarship defines Thirdspace as the production of space through usage (Lefebvre) and as a spatial concept in which traditional binary oppositions dissolve (Soja).
Karolien Vermeulen
doaj
Reader Response: Teaching NeuroImage: Partially Reversible Widespread Leukoencephalopathy Associated With Atypical Hemolytic Uremic Syndrome. [PDF]
Neurology, 2023 Graber J.
europepmc +1 more source
Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization
Molecular Oncology, EarlyView.In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu +13 more
wiley +1 more source
Personalizing the Reading Experience: Implementing the Reader-Response Approach in TEFL Contexts [PDF]
مجلة العلوم التربوية بکلية التربية، جامعة الغردقةThis article presents an overview of the Reader-Response Approach and its significance in personalizing the reading experience in contexts of teaching English as a Foreign Language (TEFL).
ا.د. عيد عبدالواحد علي درويش +3 more
doaj +1 more source