Results 121 to 130 of about 422,269 (304)
Molecular Oncology, EarlyView.Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch +13 more
wiley +1 more source
Talking like the rain to the empirical disciplines
Forma y Función, 2010 Recent developments in computational power have been applied to Shakespearean studies in such a way as to demonstrate that unprecedented collation and insight into authorial work will occur.
Smallwood Matthew
doaj +2 more sources
Ilha do Desterro, 2008 There has been some uproar about the canon, what constitutes it and what it constitutes, how it is instituted and its validity in the teaching of literature.1 As important as thoughts about what literature should be taught are discussions on how it could
Clarissa Menezes Jordão
doaj
X: Poems & Anti-Poems by Shane Rhodes [PDF]
, 2014 A review of Shane Rhodes\u27 X: Poems & Anti-Poems. This review focuses on the link between language and landscape, and considers the ways in which that link, reflected in Rhodes\u27 work, comments upon the use of language as an oppressive tool in the ...
Miller, Tom
core +1 more source
Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma
Molecular Oncology, EarlyView.The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic +5 more
wiley +1 more source
The Characteristics of Primitivism in Ernest Hemingway's the Old Man and the Sea [PDF]
, 2002 Authors of any periods unconsciously tend to explore the sublimity and free expression of feeling, the simplicity of style and themes, the portrayal of the 'noble savage', the glorification of nature, the excitement of physical power and sensuous use of ...
Santosa, V. (Vyrna)
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Molecular Oncology, EarlyView.Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute +4 more
wiley +1 more source
Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer
Molecular Oncology, EarlyView.Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni +11 more
wiley +1 more source
Sarah laughed: women\u27s voices in the Old Testament [PDF]
, 1996 Reviewed Book: Dennis, Trevor. Sarah laughed: women\u27s voices in the Old Testament.
McLeese, Constance E.
core +1 more source
Rethinking plastic waste: innovations in enzymatic breakdown of oil‐based polyesters and bioplastics
FEBS Open Bio, EarlyView.Plastic pollution remains a critical environmental challenge, and current mechanical and chemical recycling methods are insufficient to achieve a fully circular economy. This review highlights recent breakthroughs in the enzymatic depolymerization of both oil‐derived polyesters and bioplastics, including high‐throughput protein engineering, de novo ...
Elena Rosini +2 more
wiley +1 more source