Results 121 to 130 of about 421,956 (305)
The Characteristics of Primitivism in Ernest Hemingway's the Old Man and the Sea [PDF]
, 2002 Authors of any periods unconsciously tend to explore the sublimity and free expression of feeling, the simplicity of style and themes, the portrayal of the 'noble savage', the glorification of nature, the excitement of physical power and sensuous use of ...
Santosa, V. (Vyrna)
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Molecular Oncology, EarlyView.The noncoding region of the genome plays a key role in regulating gene expression, and mutations within these regions are capable of altering it. Researchers have identified multiple functional noncoding mutations associated with increased cancer risk in the genome of breast cancer patients.
Arnau Cuy Saqués +3 more
wiley +1 more source
Ilha do Desterro, 2008 There has been some uproar about the canon, what constitutes it and what it constitutes, how it is instituted and its validity in the teaching of literature.1 As important as thoughts about what literature should be taught are discussions on how it could
Clarissa Menezes Jordão
doaj
Molecular Oncology, EarlyView.We developed a cost‐effective methylation‐specific droplet digital PCR multiplex assay containing tissue‐conserved and tumor‐specific methylation markers. The assay can detect circulating tumor DNA with high accuracy in patients with localized and metastatic colorectal cancer.
Luisa Matos do Canto +8 more
wiley +1 more source
TALKING LIKE THE RAIN TO THE EMPIRICAL DISCIPLINES
Forma y Función, 2010 Recent developments in computational power have been applied to Shakespearean studies in such a way as to demonstrate that unprecedented collation and insight into authorial work will occur.
Matthew Smallwood
doaj +2 more sources
A fragmentising interface to a large corpus of digitized text: (Post)humanism and non-consumptive reading via features [PDF]
, 2015 While the idea of distant reading does not rule out the possibility of close reading of the individual components of the corpus of digitized text that is being distant-read, this ceases to be the case when parts of the corpus are, for reasons relating to
Bhattacharyya, Sayan +2 more
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Molecular Oncology, EarlyView.Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice +16 more
wiley +1 more source
ATF4‐mediated stress response as a therapeutic vulnerability in chordoma
Molecular Oncology, EarlyView.We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone +11 more
wiley +1 more source
Molecular Oncology, EarlyView.The cancer problem is increasing globally with projections up to the year 2050 showing unfavourable outcomes in terms of incidence and cancer‐related deaths. The main challenges are prevention, improved therapeutics resulting in increased cure rates and enhanced health‐related quality of life.
Ulrik Ringborg +43 more
wiley +1 more source
Acta Scientiarum: Language and Culture, 2009 O trabalho empreendido tem como objetivo apresentar uma análisecomparativa de alguns estudos sobre leitura provenientes da teoria literária e da linguística.
Marta Yumi Ando
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