ABSTRACT Objective CDKL5 deficiency disorder (CDD) is a rare, severe developmental and epileptic encephalopathy. There is a pressing need to develop effective and sustainable therapeutic strategies. We aimed to investigate the causal association between febrile episodes and epileptic seizures for therapeutic implications in CDD patients.
Siyi Wang +13 more
wiley +1 more source
Polygenic scores in the study of gene-environment interplay and stress-related psychopathology. [PDF]
Kouris M, Kumsta R.
europepmc +1 more source
Objective The objective of this article is to identify perceptions of patients with systemic lupus erythematosus (SLE) regarding artificial intelligence (AI)–based online symptom assessment tools, and the potential of these tools to address diagnostic barriers.
Olivia A. Stein +7 more
wiley +1 more source
Overseas reception of English translations of Journey to the West: Temporal dynamics, cross-platform sentiment patterns, and topic modeling. [PDF]
Jia N, Xin J, Wang Y.
europepmc +1 more source
Caregiver Perspectives on the Burden of Disease and Treatment in Uncontrolled Gout
Objective Uncontrolled gout (UG) refers to persistently elevated serum urate (SU) levels >6 mg/dL and ongoing gout symptoms despite use of urate‐lowering therapy (ULT). The objective of this study was to evaluate the burden associated with informal caregiving for individuals with UG.
Angelo Gaffo +6 more
wiley +1 more source
Diagnostic performance of abbreviated non-contrast liver MRI for detecting synchronous colorectal liver metastases. [PDF]
Charoenchue P +6 more
europepmc +1 more source
A Workflow to Accelerate Microstructure‐Sensitive Fatigue Life Predictions
This study introduces a workflow to accelerate predictions of microstructure‐sensitive fatigue life. Results from frameworks with varying levels of simplification are benchmarked against published reference results. The analysis reveals a trade‐off between accuracy and model complexity, offering researchers a practical guide for selecting the optimal ...
Luca Loiodice +2 more
wiley +1 more source
EUPopLink Country report - Montenegro. [PDF]
Lazarevic A, Surlić S.
europepmc +1 more source
Towards Defect Phase Diagrams: From Research Data Management to Automated Workflows
A research data management infrastructure is presented for the systematic integration of heterogeneous experimental and simulation data required for defect phase diagrams. The approach combines openBIS with a companion application for large‐object storage, automated metadata extraction, provenance tracking and federated data access, thereby supporting ...
Khalil Rejiba +5 more
wiley +1 more source
Response to the letter 'Impact of the free health care policies in Burkina Faso: Underscoring important nuances'. [PDF]
Aye TT +8 more
europepmc +1 more source

