Results 71 to 80 of about 422,269 (304)

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

Molecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son, Lily L. Remsing Rix, Bin Fang, Eric A. Welsh, Nicole V. Bremer, Valentina Foglizzo, Paola Roa, Nickole Sigcha‐Coello, Yi Liao, Eric B. Haura, Alexander Drilon, John M. Koomen, Emiliano Cocco, Uwe Rix   +13 more
wiley   +1 more source

In defence of the ethical evaluation of narrative art [PDF]

, 2001
In this paper I will evaluate two distinct models defending the ethical evaluation of narrative art – moderate moralism and ethicism. Both models can be defended against criticisms current in the philosophical literature but at some cost.
Kieran, M.
core   +1 more source

Cis‐regulatory and long noncoding RNA alterations in breast cancer – current insights, biomarker utility, and the critical need for functional validation

Molecular Oncology, EarlyView.
The noncoding region of the genome plays a key role in regulating gene expression, and mutations within these regions are capable of altering it. Researchers have identified multiple functional noncoding mutations associated with increased cancer risk in the genome of breast cancer patients.
Arnau Cuy Saqués, Aracele Martinez‐Mendez, John Crown, Alex Eustace   +3 more
wiley   +1 more source

Begabte Schwindlerinnen. Über die Inszenierungen der Lüge bei Ljudmila Ulickaja

Cahiers d’Études Germaniques, 2015
In her novel, Women’s Lies (Russian title: Skvoznaja linija [Through Line], 2002), Lyudmila Ulickaja creates a veritable typology of female lies and provides an explicit reflection on the specific characteristics of female tall tales.
Christiane SOLTE-GRESSER
doaj   +1 more source

Determinants of impact : towards a better understanding of encounters with the arts [PDF]

, 2007
The article argues that current methods for assessing the impact of the arts are largely based on a fragmented and incomplete understanding of the cognitive, psychological and socio-cultural dynamics that govern the aesthetic experience.
Abercrombie N., Atkins B., Averill J. R., Belfiore E., Belfiore E., Bennett S., Berleant A., Berleant A., Bishop C., Bondora J. T., Boruah B., Bourdieu P., Bourdieu P., Bourriaud N., Budd M., Butler C., Car[ugrave] A., Carey J., Cole S., Crawford M., Csikszentmihalyi M., Csikszentmihalyi M., Csikszentmihalyi M., Danto A. C., De Bolla P., Denzin N. K., Duffy E., Eleonora Belfiore, Elkins J., Eversmann P., Fannin H. A., Feagin S. L., Fechner G. T., Fisher J. L., Goldie P., Heelas P., Hjort M., Hogan P. C., Jowell T., Katz-Gerro T., Kennard J. E., Kershaw B., Kesner L., Kiell N., Kreitler H., LeVasseur J. J., Lupton D., Maclagan D., Maquet J., McGrath J., McMahon J. A., Miesen H., Mitias M. H., Mittleman L. B., Mortensen P., Motion A., Mullan J., Nell V., Nosek M. A., Nozick R., Oatley K., Oliver Bennett, Parkinson B., Parsons M. J., Phillips D. P., Pirkis J., Price K., Radway J., Ramachandran V. S., Reason M., Richards I. A., Sarland C., Sartre J. P., Sauter W., Segel E., Shweder R. A., Solso R. L., Sparshott F., Storey J., Tompkins J. P., Tulloch J., Valkenburg P. M., Wood D., Yanal R. J., Young K., Zeki S., Zeki S.   +86 more
core   +1 more source

Detection of circulating tumor DNA in colorectal cancer patients using a methylation‐specific droplet digital PCR multiplex

Molecular Oncology, EarlyView.
We developed a cost‐effective methylation‐specific droplet digital PCR multiplex assay containing tissue‐conserved and tumor‐specific methylation markers. The assay can detect circulating tumor DNA with high accuracy in patients with localized and metastatic colorectal cancer.
Luisa Matos do Canto, Louise Raunkilde, Jan Lindebjerg, Mads Malik Aagaard, Christina Therkildsen, Jakob Kleif, Lars Henrik Jensen, Torben Frøstrup Hansen, Rikke Fredslund Andersen   +8 more
wiley   +1 more source

Theoretical Views Underlying the Selection of Classroom Activities: Paying Attention to the Classroom of English Literature in EFL Context

TEFLIN Journal, 2003
This essay reviews literature on the theoretical views underlying the selection of activities for classrooms of English literature teaching in EFL context.
Yazid Basthomi
doaj   +3 more sources

Childhood Hermeneutics and the Uniqueness of the Aesthetic Reading of Children’s Literature

Encyclopaideia
The purpose of this paper is to reflect on the uniqueness of the aesthetic reading of children’s literature and child hermeneutics as foundations for reading education.
Stefania Carioli
doaj   +1 more source

Towards critical literacy : literature and teachers' reactions to reader-response theories : a thesis presented in fulfilment of the requirements for the degree of Master of Arts in Second Language Teaching at Massey University [PDF]

, 1999
Much poststructuralist literary theory, in particular that derived from reader-response theories, points to the need for the development in readers of a more critical literacy.
Brown, R. A. Julie
core  

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source