Results 161 to 170 of about 1,982,301 (342)

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

open access: yesMolecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto   +13 more
wiley   +1 more source

School Quality, Educational Attainment and Aggregation Bias [PDF]

open access: yes
Data from 31 countries participating in the Programme for International Student Assessment (PISA) is used to estimate education production functions for reading literacy.The analysis suggests that the probability of finding statistically significant and ...
Michael Fertig, Robert E. Wright
core  

Developing Learners’ Self-Assessment Accuracy in Reading Skills and Strategies [PDF]

open access: yes, 2008
Self-assessment is one example of what is currently called alternative assessment. Alternative assessment procedures are often developed in an attempt to make testing and assessment more responsive and accountable to individual learners, to promote ...
Azizmalayeri, Faramarz
core  

Effect of chemotherapy on passenger mutations in metastatic colorectal cancer

open access: yesMolecular Oncology, EarlyView.
Changes in passenger mutation load and predicted immunotherapy response after chemotherapy treatment. Tumor cells rich with passenger mutations have increased sensitivity to chemotherapy. Correlation of passenger mutations with neoantigen load suggests highly mutated clones promote a more effective response to immunotherapy, and therefore, first‐line ...
Marium T. Siddiqui   +6 more
wiley   +1 more source

Reading errors made by skilled and unskilled readers: evaluating a system that generates reports for people with poor literacy [PDF]

open access: yes, 2004
This study evaluates a natural language generation system that creates literacy assessment reports in order to create more readable documents. Prior research assessed comprehension and reading speed on modified documents.
Reiter, Ehud, Williams, Sandra
core  

Molecular characterisation of human penile carcinoma and generation of paired epithelial primary cell lines

open access: yesMolecular Oncology, EarlyView.
Generation of two normal and tumour (cancerous) paired human cell lines using an established tissue culture technique and their characterisation is described. Cell lines were characterised at cellular, protein, chromosome and gene expression levels and for HPV status.
Simon Broad   +12 more
wiley   +1 more source

EARLY READING ASSESSMENT INSTRUMENTS: ABILITIES AND PROCESSES INVOLVED

open access: yesSignum: Estudos da Linguagem, 2017
This study investigates the following early reading assessment instruments: “Bateria de Recepção e Produção da Linguagem Verbal” (SCLIAR-CABRAL, 2003a) and “Teste de Competência de Leitura de Palavras e Pseudopalavras” (SEABRA; CAPOVILLA, 2010).
Ana Cláudia de Souza   +1 more
doaj  

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