Results 161 to 170 of about 444,355 (314)

YIPFα1A expression is regulated by multilayered molecular mechanisms

FEBS Open Bio, EarlyView.
YIPFα1A, a five‐pass Golgi protein, is regulated at multiple layers. (1) Rare‐codon enrichment drives translation‐coupled mRNA decay. (2) A proximal 3′‐UTR element stabilizes mRNA. (3) A distal 3′‐UTR element included by alternate poly(A) site usage represses translation, which can be overridden by the proximal 3′‐UTR element.
Tokio Takaji, Yurika Nakanishi, Nobuhiro Nakamura   +2 more
wiley   +1 more source

Evolving microbiology laboratories: mastering automated culture-based processes and molecular assays, an institutional experience. [PDF]

Front Cell Infect Microbiol
Cherkaoui A, Renzi G, Fischer A, Tittel-Elmer M, Tognon M, François P, Lazarevic V, Schrenzel J.   +7 more
europepmc   +1 more source

Identifying transcription factors controlling the basal expression of human MRP4 highlights a substantial role for Sp1

FEBS Open Bio, EarlyView.
The MRP4 transporter exports several drugs and signaling molecules. Here, we identified key promoter elements regulating basal MRP4 expression. Using reporter assays, we defined a conserved region with essential Sp1 and contributory Ets sites, which controlled basal MRP4 expression.
Debora Singer, Angelique Kragl, Katrin Ziems, Juliane Glaubitz, Sophie Grammbauer, Susanne Hildebrandt, Mladen V. Tzvetkov, Gabriele Jedlitschky   +7 more
wiley   +1 more source

Action! suspense! culture! insight! : reading stories in the classroom

, 1983
Made available in DSpace on 2010-12-21T22:26:36Z (GMT). No. of bitstreams: 3 ctrstreadeducrepv01983i00045_opt.pdf: 436893 bytes, checksum: 936b910948f85614f4ea8b489a63e4b2 (MD5) ctrstreadeducrepv01983i00045_tei.xml: 73152 bytes, checksum ...
Bruce, Bertram C.
core  

24-hour movement behaviors in association with academic performance in children and adolescents: cross-sectional compositional data analysis. [PDF]

J Act Sedentary Sleep Behav
Syväoja HJ, Kukko T, Asunta P, Hakonen H, Kulmala J, Lerkkanen MK, Räsänen P, Tammelin TH.   +7 more
europepmc   +1 more source

Derivation and characterization of retinal pigment epithelium from urine‐derived iPSCs

FEBS Open Bio, EarlyView.
Age‐related macular degeneration causes vision loss via RPE dysfunction and loss. Traditional iPSC therapies rely on invasive biopsies, limiting scalability. Here, we utilize urine‐derived stem cells as an accessible source to generate u‐iPSCs, successfully differentiated into pigmented RPE. This “Urine‐to‐Retina” platform provides a promising path for
Daniella Beiner, Hainan Zhu, Carol Christine Bosholm, Heuy‐Ching Wang, Tracy Criswell, Anthony Atala, Jian‐Xing Ma, Yuanyuan Zhang   +7 more
wiley   +1 more source

Impact of Total Laboratory Automation on Urine Culture Turnaround Time: A Comparative Study Between Manual Workflow and WASPLab™. [PDF]

Diagnostics (Basel)
Khalid F, Alzahrani AJ, Mohammed H, Gamma AKA, Hassan ME, Poulose C, ElSheikh A, Sumaily K, Alharbi AA, Aldrous NF, Alsaadan M, Alnamnakani M, Khojah OT.   +12 more
europepmc   +1 more source

Optimizing photoactivation of PA‐mCherry for optical pooled CRISPR screens

FEBS Open Bio, EarlyView.
Photoactivatable PA‐mCherry finds widespread use to optically tag individual cells. However, confocal 405 nm UV laser‐scanning (normal scan) is much less efficient than widefield UV illumination, limiting the use of PA‐mCherry on confocal instruments. We remedy this limitation by reporting that rapid and repeated confocal scanning with a low‐intensity,
Sravasti Mukherjee, Giulia Zanetti, Bram van den Broek, Kees Jalink   +3 more
wiley   +1 more source

Total Laboratory Automation for Microbiology Activities: An HTA Analysis in an Italian Laboratory Setting. [PDF]

Clinicoecon Outcomes Res
Foglia E, Garagiola E, Ferrario L, Adorisio E, Gagliardi G, Lenoci FD.   +5 more
europepmc   +1 more source

Pharmacological inhibition of the PERK pathway modulates hepatocellular carcinoma growth and immune signaling

FEBS Open Bio, EarlyView.
Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero, Maria Kopsida, Nathalie Arendt, Hans Lennernäs, Markus Sjöblom, Femke Heindryckx   +5 more
wiley   +1 more source