Results 71 to 80 of about 102,669 (304)

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

Outcomes and impact evaluation of reading promotion programmes.

, 2023
In recent decades, national reading promotion programmes in many developed countries have become a particularly relevant task of education and culture policy, the solution of which is expected to contribute to social cohesion and the development of ...
Rimkutė, Audronė,, Lukoševičiūtė, Laura,   +1 more
core   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Reading Engineering: Integration of Robotics in Reading Promotion

Управление культурой
In today’s world, where gadgets have become an integral part of children's lives and artificial intelligence is increasingly taking on more and more functions, the impact of these trends on the development of the younger generation is becoming ...
Natalya V. Beteva
doaj   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers

Molecular Oncology, EarlyView.
This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel, Peyman Zarrineh, Nathnael T. Tuffa, Jigar H. Sheth, Sumitra Mohan, Mudassar Iqbal, Sankari Nagarajan   +6 more
wiley   +1 more source

Determinants of Reading Habits and Reading Promotion in the Era of Technology: A Library and Information Science Perspective [PDF]

International Journal of Information Science and Management
Reading habits and the promotion of a reading culture are recognized as essential social imperatives in many countries, underpinning cultural identity.
Mohammad Reza Niazmand, Mohammad Reza Vasfi, Mahshid Eltemasi   +2 more
doaj   +1 more source

Reading games: possibilities for promoting engagement in reading

Signum: Estudos da Linguagem, 2020
Considering the dynamicity of the current contemporary and technological world and the responsibility of reading in human development, school, teacher and student took on a new configuration, requiring changes in the way of teaching and learning. In view of this reality, the present article originated from research carried out in the Professional ...
Kelly Rose Flávio Veloso Santos, Fábia Magali Santos Vieira   +1 more
openaire   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Assessing health promotion activities of community nurses in a GP surgery in the North-East of England [PDF]

, 2000
The purpose of this research was to study the extent to which community nurses are involved in health promotion activities in a GP surgery in the North-East of England, and to investigate whether these activities meet the needs of their clients A ...
Duaso, Maria Jose
core