Results 161 to 170 of about 358,190 (262)

Hyperosmotic stress‐induced redistribution of pre‐mRNA cleavage factor I subunits is associated with shifts in alternative polyadenylation

FEBS Open Bio, EarlyView.
Hyperosmotic stress triggers the relocation of the CFIm complex from the nucleus to the cytoplasm. This shift creates a nuclear ‘stoichiometric bottleneck’, limiting CFIm availability for mRNA processing. Consequently, specific mRNAs like NUDT21 and DICER1 undergo targeted 3′UTR shortening, demonstrating how spatial protein dynamics drive rapid ...
Hitomi Soumiya, Masatake Osawa, Hidefumi Fukumitsu   +2 more
wiley   +1 more source

One-year impact of an ambulatory pulmonary curriculum for fellows leveraging adult learning theory. [PDF]

ATS Sch
McAvoy KA, Gielissen KA, Honiden S, Possick JD.   +3 more
europepmc   +1 more source

Loss of AMBRA1 activates MAPK and angiogenesis signaling pathways in melanoma cells

FEBS Open Bio, EarlyView.
Loss of AMBRA1 in melanoma cells activates multiple oncogenic pathways associated with tumor progression. Transcriptomic and protein network analyses revealed that AMBRA1 depletion enhances MAPK/ERK signaling, angiogenesis, TGF‐β/EMT signaling, and Wnt/axon guidance pathways.
Milad Ibrahim, Marco Corazzari, Iman Osman, Jane Armstrong, Noel Carter   +4 more
wiley   +1 more source

Data-Driven Insights into E-Learning: A Comprehensive Review of Eye-Tracking Applications in Learning Systems. [PDF]

J Eye Mov Res
Bendjebar S, Lafifi Y, Boudjehem R, Laouissi A.   +3 more
europepmc   +1 more source

Putting Computerized Instruction to the Test: A Randomized Evaluation of a "Scientifically-based" Reading Program [PDF]

Although schools across the country are investing heavily in computers in the classroom, there is surprisingly little evidence that they actually improve student achievement.
Cecilia E. Rouse, Alan B. Krueger
core  

Dose‐dependent hepatotoxicity of hydrogen peroxide in HepG2 cells and its modulation by CYP450 induction

FEBS Open Bio, EarlyView.
NMR metabolomics revealed concentration‐dependent metabolic perturbations in HepG2 cells exposed to H2O2. Rifampicin pretreatment enhanced metabolic competence, attenuated toxin‐induced alterations and produced metabolite profiles more consistent with human liver physiology, supporting the use of CYP450‐induced HepG2 models for improved in vitro ...
Maren Jinks, Garth L. Maker, Emily C. Davies, Berin A. Boughton, Samantha Lodge   +4 more
wiley   +1 more source

Factors Influence Reading From Screen of Arabic Textbook for Learning by Children Aged 9 to 13

The problem with e-texts are related to the way texts are displayed on a screen, with multiple and different aspects that affect legibility, making readers prefer to read a paper format rather than e-resources.
Abubaker, Azza
core   +1 more source

Lexical Elaboration and Intentional Vocabulary Acquisition: An Eye-Tracking Study. [PDF]

J Eye Mov Res
Lee T, Choi B, Choi S, Kweon SO.
europepmc   +1 more source

Super‐Refractory Status Epilepticus (SRSE) in a Patient With Compound Heterozygous OPA1 Variants: Case Report and Literature Review

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Super‐Refractory Status Epilepticus (SRSE) is a rare, life‐threatening neurological emergency with unclear etiology in many cases. Mitochondrial dysfunction, often due to disease‐causing genetic variants, is increasingly recognized as a cause, with each gene producing distinct pathophysiological mechanisms.
Pouria Mohammadi, Lara Basovic, Christopher Michael McGraw   +2 more
wiley   +1 more source

Direct RNA Sequencing of Dengue and Chikungunya Viruses with Ultra-Low Input and Custom Multiplexing. [PDF]

J Biomol Tech
Tanvet C, Baum C, O'Connor O, Bohers C, Dupont-Rouzeyrol M, Monot M.   +5 more
europepmc   +1 more source