Results 151 to 160 of about 403,921 (297)

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

EC72-421 Guides to Buying Women\u27s Ready Made Dresses

, 1972
Extension Circular 72-421 is a guide to buying women\u27s ready made ...
Kreifels, Anna Marie, Speece, Jane
core  

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

Recension de Poésies ready-made, XXe-XXIe siècles

, 2016
Une recension de mon ouvrage Poésies et ready-made, XXe-XXIe siècles, paru en octobre 2015 aux éditions l'Harmattan (collection Arts & médias) par Nicolas Tardy, est à lire dans le Cahier Critique de Poésie (CCP) de mai 2016 : http ...
Gaëlle Théval
core   +1 more source

Nosotros también tenemos armas We have weapons too

ARQ, 2011
Como red entre el deconstructivismo aparecido a fines del s. XX y la arquitectura de la marginalidad, el vínculo entre diseño, improvisación, transferencia tecnológica y reciclaje puede entregar algunas claves para una arquitectura de emergencia.There is
Rubén Alcolea, Jorge Tárrago
doaj  

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

EC72-427 Altering Women\u27s Ready Made Dresses

, 1972
Extension Circular 72-427 is about altering women’s ready made ...
Kreifels, Anna Marie, Speece, Jane
core  

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source

I ready-made di Duchamp e il vedere-come in Wittgenstein

, 2013
Il contributo si propone di guardare i ready-made di Duchamp attraverso alcune riflessioni filosofiche di Wittgenstein: guardare-attraverso i ready-made per indagarne le possibilità, ovvero guardare prima di tutto i ready-made attraverso i ready-made ...
Moira De Iaco
core  

Automated FRAP microscopy for high‐throughput analysis of protein dynamics in chromatin organization and transcription

FEBS Open Bio, EarlyView.
RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz, Bart Geverts, Johan A. Slotman, Andrea Sacchetti, Stefan Prekovic, Martin E. van Royen, Adriaan B. Houtsmuller   +6 more
wiley   +1 more source