Results 31 to 40 of about 33,341 (255)
FEBS Letters, EarlyView.We present robust protocols for the preparation of supported lipid bilayers (SLBs) incorporating either Salmonella smooth LPS or outer membrane vesicles (OMVs). We use a combination of quartz crystal microbalance with dissipation (QCM‐D) and fluorescence microscopy to both characterize the SLBs of various compositions and to probe their interactions ...
Hudson P. Pace +6 more
wiley +1 more source
Colourimetric Detection of Formalin Concentration in Fixing Solutions using Schiff’s Reagent: An In-vitro Study [PDF]
Journal of Clinical and Diagnostic ResearchIntroduction: Formalin is a widely used tissue fixative in histopathology. Maintaining a precise formalin concentration in fixing solutions is essential, as both over-fixation and under-fixation can compromise tissue quality and pose health risks to ...
K Namira Fateen +2 more
doaj +1 more source
Molecular Oncology, EarlyView.Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau +36 more
wiley +1 more source
KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer
Molecular Oncology, EarlyView.Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan +16 more
wiley +1 more source
Evaluation of the RT-LAMP/CRISPR-Cas12 diagnostic method for SARS-COV-2
Acta Scientiarum. Health Sciences, 2023 Brazil is one of the countries that least performs detection tests for SARS-COV-2, even though diagnosing cases is the most effective way to control epidemics, which is crucial to guide public policies.
Graziela Parente Peduti +1 more
doaj +1 more source
Technology Behind Diagnostic Reagent Strips [PDF]
Laboratory Medicine, 2000 Diagnostic reagent strips are commonly used in clinical analysis of urine and blood, in particular for monitoring glucose concentration. Results are obtained instrumentally or visually as thresholds and quantitative outputs. Dry reagents are applied in the construction of strips in a variety of ways.
openaire +1 more source
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer
Molecular Oncology, EarlyView.Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas +16 more
wiley +1 more source
FEBS Open Bio, EarlyView.Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane +11 more
wiley +1 more source
Role of urine reagent strips in early diagnosis of meningitis [PDF]
Journal of Krishna Institute of Medical Sciences UniversityBackground: Early diagnosis of meningitis is critical to reducing associated morbidity and mortality, especially in resource-limited settings. Conventional Cerebrospinal Fluid (CSF) analysis is accurate but time-consuming.
Preeti Singh +3 more
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