Results 31 to 40 of about 33,218 (255)
Within‐clinic Reagent Strip Lipid Measurement
Diabetic Medicine, 1989 The agreement between the Reflotron dry chemistry analyser and laboratory methods for measurement of total cholesterol and triglycerides was assessed by studying the between‐method variability for individual samples. A paired comparison of replicate measurements from venous blood was made for 105 cholesterol and 90 triglyceride specimens.
Neil, H +3 more
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Molecular Oncology, EarlyView.Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau +36 more
wiley +1 more source
Colourimetric Detection of Formalin Concentration in Fixing Solutions using Schiff’s Reagent: An In-vitro Study [PDF]
Journal of Clinical and Diagnostic ResearchIntroduction: Formalin is a widely used tissue fixative in histopathology. Maintaining a precise formalin concentration in fixing solutions is essential, as both over-fixation and under-fixation can compromise tissue quality and pose health risks to ...
K Namira Fateen +2 more
doaj +1 more source
Molecular Oncology, EarlyView.Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute +4 more
wiley +1 more source
KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer
Molecular Oncology, EarlyView.Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan +16 more
wiley +1 more source
Technology Behind Diagnostic Reagent Strips [PDF]
Laboratory Medicine, 2000 Diagnostic reagent strips are commonly used in clinical analysis of urine and blood, in particular for monitoring glucose concentration. Results are obtained instrumentally or visually as thresholds and quantitative outputs. Dry reagents are applied in the construction of strips in a variety of ways.
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Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
Evaluation of the RT-LAMP/CRISPR-Cas12 diagnostic method for SARS-COV-2
Acta Scientiarum. Health Sciences, 2023 Brazil is one of the countries that least performs detection tests for SARS-COV-2, even though diagnosing cases is the most effective way to control epidemics, which is crucial to guide public policies.
Graziela Parente Peduti +1 more
doaj +1 more source
FEBS Open Bio, EarlyView.Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane +11 more
wiley +1 more source
Acute caffeine treatment protects the developing retina from ischemia‐induced cell death
FEBS Open Bio, EarlyView.Caffeine reduces cell death in the developing retina under ischemia (OGD). This effect does not involve BDNF upregulation or antioxidant pathways (NRF2/VEGF). Neuroprotection occurs mainly through adenosine A2A receptor antagonism, decreasing glutamate release and excitotoxicity, highlighting caffeine's potential as an acute neuroprotective agent in ...
Amanda Alves Nascimento +6 more
wiley +1 more source