Results 91 to 100 of about 99,304 (262)

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Starlikeness associated with certain strongly functions

Heliyon
Let κ be an analytic function in the open unit disc U in the complex plane with κ(0)=1. Then κ∈K(λ) if and only if κ(t)≺ϕλ(t), where ≺ is a subordination relation and the function ϕλ(t):=(1+t)λ, for ...
Afis Saliu, Kanwal Jabeen, Jianhua Gong, Sarfraz Nawaz Malik, Hala Alaqad   +4 more
doaj   +1 more source

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

FEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang, Hyo Been Jin, Chang Min Kim, So Yeon Lee, Hyun Ho Park   +4 more
wiley   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes

FEBS Letters, EarlyView.
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg, Martine Hjeltnes, Josephine Krieger, Joshua E. Elias, Maria Stensland, Kristian Holm, Xiaojun Jiang, Chuki Khangsar, Tuula A. Nyman, Arthur Kaser, Johannes R. Hov, Tom H. Karlsen, Nicole C. Kaneider, Frode L. Jahnsen, Georg Schneditz   +14 more
wiley   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Coefficient inequalities for certain analytic functions

International Journal of Mathematics and Mathematical Sciences, 2002
For real α(α>1), we introduce subclasses M(α) and N(α) of analytic functions f(z) with f(0)=0 and f′(0)=1 in U. The object of the present paper is to consider the coefficient inequalities for functions f(z) to be in the classes M(α) and N(α).
Junichi Nishiwaki, Shigeyoshi Owa
doaj   +1 more source

Discerning protein pools by selective staining with self‐labeling tags

FEBS Letters, EarlyView.
Cell surface proteins have an intra‐ and extracellular pool. Combining genetic fusion to self‐labeling tags that can be addressed with small molecule fluorophores allows separating these pools. We highlight recent developments and techniques for state‐of‐the‐art interrogation of cell surface proteins in the complex tissue setting.
Kati Fischermanns, Johannes Broichhagen
wiley   +1 more source

Analyticity of the global attractor for the 3D regularized MHD equations

Electronic Journal of Differential Equations, 2016
We study the three-dimensional (3D) regularized magnetohydrodynamics (MHD) equations. Using the method of splitting of the asymptotic approximate solutions into higher and lower Fourier components, we prove that the global attractor of the 3D ...
Caidi Zhao, Bei Li
doaj  

Chebyshev’s Method for Multiple Zeros of Analytic Functions: Convergence, Dynamics and Real-World Applications

Mathematics
This paper deals with the convergence and dynamics of Chebyshev’s method for simple and multiple zeros of analytic functions. We establish a local convergence theorem that provides error estimates and exact domains of initial approximations to guarantee ...
Stoyanka G. Kostadinova, Stoil I. Ivanov
doaj   +1 more source