Results 191 to 200 of about 41,831,427 (302)

Towards real-time analysis of liquid jet alignment in serial femtosecond crystallography. [PDF]

J Appl Crystallogr, 2022
Patel J, Round A, Bielecki J, Doerner K, Kirkwood H, Letrun R, Schulz J, Sikorski M, Vakili M, de Wijn R, Peele A, Mancuso AP, Ab Bey B.   +12 more
europepmc   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Editorial: Actionable learning analytics in education: an opportunity to close the learning loop

Frontiers in Education
JohnPaul Kennedy, JohnPaul Kennedy, Florence Gabriel, Florence Gabriel, Malgorzata Korolkiewicz, Malgorzata Korolkiewicz, Irina Rets, Bart Rienties   +7 more
doaj   +1 more source

Real-time analysis of soccer ball-player interactions using graph convolutional networks for enhanced game insights. [PDF]

Sci Rep
Majeed F, Nazir M, Swart K, Agus M, Schneider J.   +4 more
europepmc   +1 more source

Real-time analysis of heart rate variability during aerobic exercise in patients with cardiovascular disease. [PDF]

Int J Cardiol Heart Vasc, 2022
Ikura H, Katsumata Y, Seki Y, Ryuzaki T, Shiraishi Y, Miura K, Sato K, Fukuda K.   +7 more
europepmc   +1 more source

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source

Real-time analysis of initiation regulation systems during the progression of the reconstituted chromosomal replication cycle. [PDF]

Sci Rep
Kanoh K, Su'etsugu M.
europepmc   +1 more source

Rapid detection of Staphylococcus aureus and Streptococcus pneumoniae by real-time analysis of volatile metabolites. [PDF]

iScience, 2022
Gómez-Mejia A, Arnold K, Bär J, Singh KD, Scheier TC, Brugger SD, Zinkernagel AS, Sinues P.   +7 more
europepmc   +1 more source

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source

Real-Time Analysis of Changes in Internal and External Root Temperatures Using Different Systems for Activating the Irrigation Solution. [PDF]

Int J Dent
Dotto MEP, Savaris JM, de Lima Dias-Junior LC, Schmidt TF, da Fonseca Roberti Garcia L, da Silveira Teixeira C, Bortoluzzi EA.   +6 more
europepmc   +1 more source