Results 101 to 110 of about 3,542,799 (379)

Real-Time Methods in Reversible Computation

open access: yes, 2015
Bennett has shown how to simulate arbitrary forwards-only computations by fully reversible computation. In particular he has given a space-efficient linear time simulation. After describing a different linear-time reversible simulation with improved space efficiency, we initiate the study of real-time simulations.
Pesu, T, Phillips, ICC
openaire   +3 more sources

Cellular liquid biopsy provides unique chances for disease monitoring, preclinical model generation and therapy adjustment in rare salivary gland cancer patients

open access: yesMolecular Oncology, EarlyView.
We quantified and cultured circulating tumor cells (CTCs) of 62 patients with various cancer types and generated CTC‐derived tumoroid models from two salivary gland cancer patients. Cellular liquid biopsy‐derived information enabled molecular genetic assessment of systemic disease heterogeneity and functional testing for therapy selection in both ...
Nataša Stojanović Gužvić   +31 more
wiley   +1 more source

Combined spatially resolved metabolomics and spatial transcriptomics reveal the mechanism of RACK1‐mediated fatty acid synthesis

open access: yesMolecular Oncology, Volume 19, Issue 6, Page 1668-1686, June 2025.
The authors analyzed the spatial distributions of gene and metabolite profiles in cervical cancer through spatial transcriptomic and spatially resolved metabolomic techniques. Pivotal genes and metabolites within these cases were then identified and validated.
Lixiu Xu   +3 more
wiley   +1 more source

Analysis on Computation-Intensive Status Update in Mobile Edge Computing [PDF]

open access: yesarXiv, 2020
In status update scenarios, the freshness of information is measured in terms of age-of-information (AoI), which essentially reflects the timeliness for real-time applications to transmit status update messages to a remote controller. For some applications, computational expensive and time consuming data processing is inevitable for status information ...
arxiv  

Integrative systems‐level analysis reveals a contextual crosstalk between hypoxia and global metabolism in human breast tumors

open access: yesMolecular Oncology, Volume 19, Issue 6, Page 1725-1736, June 2025.
Breast tumor samples scored for metabolic deregulation (M1 to M3) were given a hypoxia score (HS). The highest HS occurred in patients with strongest metabolic deregulation (M3), supporting tumor aggressiveness. HS correlated with the highest number of metabolic pathways in M1. This suggests hypoxia to be an early event in metabolic deregulation.
Raefa Abou Khouzam   +2 more
wiley   +1 more source

Integrative analysis of circulating tumor cells (CTCs) and exosomes from small‐cell lung cancer (SCLC) patients: a comprehensive approach

open access: yesMolecular Oncology, EarlyView.
This study simultaneously investigated circulating tumor cells (CTCs) and exosomes from small‐cell lung cancer (SCLC) patients. The elevated expression of JUNB and CXCR4 in CTCs was a poor prognostic factor for SCLC patients, whereas exosomal overexpression of these biomarkers revealed a high discrimination ability of patients from healthy individuals,
Dimitrios Papakonstantinou   +13 more
wiley   +1 more source

Obesity alters the fitness of peritumoral adipose tissue, exacerbating tumor invasiveness in renal cancer through the induction of ADAM12 and CYP1B1

open access: yesMolecular Oncology, Volume 19, Issue 6, Page 1612-1632, June 2025.
Tumor microenvironment drives cancer formation and progression. We analyzed the role of human cancer‐associated adipocytes from patients with renal cell carcinoma (RCC) stratified as lean, overweight, or obese. RNA‐seq demonstrated that, among the most altered genes involved in the tumor–stroma crosstalk, are ADAM12 and CYP1B1, which were proven to be ...
Sepehr Torabinejad   +13 more
wiley   +1 more source

Real-Time Massive Vector Field Data Processing in Edge Computing

open access: yesSensors, 2019
The spread of the sensors and industrial systems has fostered widespread real-time data processing applications. Massive vector field data (MVFD) are generated by vast distributed sensors and are characterized by high distribution, high velocity, and ...
Kun Zheng   +5 more
doaj   +1 more source

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