Results 131 to 140 of about 3,542,799 (379)

Computable structures on topological manifolds [PDF]

arXiv, 2017
We propose a definition of computable manifold by introducing computability as a structure that we impose to a given topological manifold, just in the same way as differentiability or piecewise linearity are defined for smooth and PL manifolds respectively.
arxiv  

Stochastic variation in the FOXM1 transcription program mediates replication stress tolerance

Molecular Oncology, Volume 19, Issue 6, Page 1633-1650, June 2025.
Cellular heterogeneity is a major cause of drug resistance in cancer. Segeren et al. used single‐cell transcriptomics to investigate gene expression events that correlate with sensitivity to the DNA‐damaging drugs gemcitabine and prexasertib. They show that dampened expression of transcription factor FOXM1 and its target genes protected cells against ...
Hendrika A. Segeren, Kathryn A. Wierenga, Frank M. Riemers, Elsbeth A. van Liere, Bart Westendorp   +4 more
wiley   +1 more source

Synthesis of Real Time Distributed Applications for Cloud Computing [PDF]

Annals of computer science and information systems, 2014
Sławomir Bąk, Stanisław Deniziak
doaj   +1 more source

Correlated, Real Time Multi-spectral Sensor Test and Evaluation (T&E) in an Installed Systems Test Facility (ISTF) Using High Performance Computing [PDF]

, 2001
John Kriz, Tom Joyner, T. L. Wilson, Greg McGraner   +3 more
openalex   +1 more source

Mapping the disaggregated economy in real-time: Using granular payment network data to complement national accounts [PDF]

arXiv
In an era of rapid change, timely and disaggregated economic insights are crucial for effective policymaking. This study explores the potential of real-time payment data to complement traditional economic measurement. Using anonmysed UK business payments from 2015-2023, we analysed inter-industry financial flows at a granular 5-digit SIC level and ...
arxiv  

Classification of acute myeloid leukemia based on multi‐omics and prognosis prediction value

Molecular Oncology, Volume 19, Issue 6, Page 1836-1854, June 2025.
The Unsupervised AML Multi‐Omics Classification System (UAMOCS) integrates genomic, methylation, and transcriptomic data to categorize AML patients into three subtypes (UAMOCS1‐3). This classification reveals clinical relevance, highlighting immune and chromosomal characteristics, prognosis, and therapeutic vulnerabilities.
Yang Song, Zhe Wang, Guangji Zhang, Jiangxue Hou, Kaiqi Liu, Shuning Wei, Yan Li, Chunlin Zhou, Dong Lin, Min Wang, Hui Wei, Jianxiang Wang, Tao Cheng, Yingchang Mi   +13 more
wiley   +1 more source

Transcriptome‐wide analysis of circRNA and RBP profiles and their molecular relevance for GBM

Molecular Oncology, EarlyView.
CircRNAs are differentially expressed in glioblastoma primary tumors and might serve as therapeutic targets and diagnostic markers. The investigation of circRNA and RNA‐binding proteins (RBPs) interactions shows that distinct RBPs play a role in circRNA biogenesis and function.
Julia Latowska‐Łysiak, Żaneta Zarębska, Marcin P. Sajek, Adriana Grabowska, Alessia Buratin, Paweł Głodowicz, Julia O. Misiorek, Konrad Kuczyński, Stefania Bortoluzzi, Marek Żywicki, Jan G. Kosiński, Agnieszka Rybak‐Wolf, Rafał Piestrzeniewicz, Anna M. Barciszewska, Katarzyna Rolle   +14 more
wiley   +1 more source

IoT- Enabled Firmness Grades of Tomato in Cold Supply Chain Using Fusion of Whale Optimization Algorithm and Extreme Learning Machine

IEEE Access
The assessment of tomato firmness is pivotal in determining optimal harvest time, evaluating shelf life, and gauging ripeness. This attribute plays a crucial role in guiding the distribution and transportation processes.
Ali Haider, Rafaqat Kazmi, Teg Alam, Rab Nawaz Bashir, Haitham Nobanee, Amjad Rehman Khan, Aqsa   +6 more
doaj   +1 more source

Know Unreported Roadway Incidents in Real-time: Early Traffic Anomaly Detection [PDF]

arXiv
This research aims to know traffic anomalies as early as possible. A traffic anomaly refers to a generic incident on the road that influences traffic flow and calls for urgent traffic management measures. `Knowing'' the occurrence of a traffic anomaly is twofold: the ability to detect this anomaly before it is reported anywhere, or it may be such that ...
arxiv  

Targeting the MDM2‐MDM4 interaction interface reveals an otherwise therapeutically active wild‐type p53 in colorectal cancer

Molecular Oncology, EarlyView.
This study investigates an alternative approach to reactivating the oncosuppressor p53 in cancer. A short peptide targeting the association of the two p53 inhibitors, MDM2 and MDM4, induces an otherwise therapeutically active p53 with unique features that promote cell death and potentially reduce toxicity towards proliferating nontumor cells.
Sonia Valentini, Giada Mele, Marika Attili, Maria Rita Assenza, Fulvio Saccoccia, Francesca Sardina, Cinzia Rinaldo, Roberto Massari, Nicola Tirelli, Alfredo Pontecorvi, Fabiola Moretti   +10 more
wiley   +1 more source