Results 71 to 80 of about 244,199 (317)

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

Human-Error Prevention for Autonomous Edge Software Using Minimalistic Modern C++

Big Data and Cognitive Computing, 2019
In science and engineering using edge-embedded software, it is necessary to demonstrate the validity of results; therefore, the software responsible for operating an edge system is required to guarantee its own validity.
Ryo Fukano, Masato Ishikawa
doaj   +1 more source

Computed tomography angiography co-registration with real-time fluoroscopy in percutaneous coronary intervention for chronic total occlusions

, 2021
Iosif Xenogiannis, Farouc A. Jaffer, Alpesh Shah, Mohamed Omer, Michael Megaly, Evangelia Vemmou, Ilias Nikolakopoulos, Bavana Rangan, Santiago García, John R. Lesser, João L. Cavalcante, M. Nicholas Burke, Emmanouil S. Brilakis   +12 more
openalex   +2 more sources

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source

β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1

Molecular Oncology, EarlyView.
Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero, Alejandro Belmonte‐Fernández, Mónica González‐Moreno, Laura Rodríguez‐Cordero, Begoña Pérez‐Valderrama, Joaquín Herrero‐Ruíz, Francisco Romero, Carmen Sáez, Miguel Á. Japón   +8 more
wiley   +1 more source

PCGen: A Fully Parallelizable Point Cloud Generative Model

Sensors
Generative models have the potential to revolutionize 3D extended reality. A primary obstacle is that augmented and virtual reality need real-time computing.
Nicolas Vercheval, Remco Royen, Adrian Munteanu, Aleksandra Pižurica   +3 more
doaj   +1 more source

Real-time patient management monitoring system based on edge computing using IoT pulse oximeter [PDF]

, 2023
Moon-Il Joo, Minsoo Kang, Dong-Yoon Kang, Hee‐Cheol Kim   +3 more
openalex   +1 more source

Characterizing the salivary RNA landscape to identify potential diagnostic, prognostic, and follow‐up biomarkers for breast cancer

Molecular Oncology, EarlyView.
This study explores salivary RNA for breast cancer (BC) diagnosis, prognosis, and follow‐up. High‐throughput RNA sequencing identified distinct salivary RNA signatures, including novel transcripts, that differentiate BC from healthy controls, characterize histological and molecular subtypes, and indicate lymph node involvement.
Nicholas Rajan, Irina Primac, Emre Etlioglu, Laurens Debruyne, Ann Janssen, Magy Sallam, Kevin Tabury, Roel Quintens, Wiebren Tjalma, Mohammed Abderrafi Benotmane   +9 more
wiley   +1 more source

Retracted: Real‐Time Detection of Body Nutrition in Sports Training Based on Cloud Computing and Somatosensory Network [PDF]

, 2023
Computational Intelligence and Neuroscience
openalex   +1 more source

Bridging the gap: Multi‐stakeholder perspectives of molecular diagnostics in oncology

Molecular Oncology, EarlyView.
Although molecular diagnostics is transforming cancer care, implementing novel technologies remains challenging. This study identifies unmet needs and technology requirements through a two‐step stakeholder involvement. Liquid biopsies for monitoring applications and predictive biomarker testing emerge as key unmet needs. Technology requirements vary by
Jorine Arnouts, Senada Koljenović, Elise Daems, Karolien De Wael, Marc Peeters, Léon C. van Kempen, Greetje Vanhoutte, Karen Zwaenepoel, Timon Vandamme   +8 more
wiley   +1 more source