Results 51 to 60 of about 1,211,761 (260)

PARK(ing) time–How park deficiency affects the biological clock in a Drosophila model of Parkinson's disease

FEBS Letters, EarlyView.
Drosophila park mutants serve as a model for Parkinson's disease. We used this strain to investigate the connection between oxidative stress and the circadian clock mechanism. We showed that increased oxidative stress affects the physiology of pacemaker cells, disrupting their daily structural plasticity. Lack of rhythmic signaling from pacemaker cells
Kamila Zientara, Kinga Skoczek, Elzbieta Pyza, Milena Damulewicz   +3 more
wiley   +1 more source

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

Real‐Time and Continuous Monitoring of Brain Deformation

Advanced Electronic Materials
Researchers have typically studied the brain by monitoring characteristic signals, such as electrophysiology and neurotransmitters by implanted electronics.
Ziwei Liu, Chengqiang Tang, Jianzheng Li, Yiqing Yang, Wenjun Li, Jiajia Wang, Sihui Yu, Chuang Wang, Yajie Qin, Qi Tong, Xuemei Sun, Huisheng Peng   +11 more
doaj   +1 more source

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

Real-Time Progress Monitoring of Bricklaying

Buildings
The construction industry is one of the largest contributors to the world economy. However, the level of automation and digitalization in the construction industry is still at its infancy in comparison with other industries due to the complex nature and ...
Ramez Magdy, Khaled A. Hamdy, Yasmeen A. S. Essawy   +2 more
doaj   +1 more source

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

Molecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen, Lucrezia De Santis, Bret M. Stephens, Vincent Bernard, Jörg C. Kalff, Lara Braun, Phillipp Leyendecker, Johannes Röttgen, Daniel Weissinger, Anirban Maitra, Paola A. Guerrero, Alexander Semaan   +11 more
wiley   +1 more source

Analysis of Fatigue Monitoring of Deepwater Drilling Riser

Shiyou jixie, 2017
The riser is the key equipment for deepwater drilling, which is prone to fatigue damage in harsh deepwater environment, so it is very important to monitor the fatigue of deepwater riser.
Li Qingpei, Su Kanhua, Han Yaokun, Luo Huilan, Zhao Ziyuan, Li Nan   +5 more
doaj  

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

Molecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau, Leonor Garcia, Hugo Arnold, Antonija Hanžek, Maialen Arrieta, Laurent R Gauthier, Christine Granotier‐Beckers, François D Boussin, Amaury Herbet, Marie Hautière, Valentin Asei‐Ceschino, Clémentin Jacques, Laura Brard, Thomas Harnois, Valérie Coronas, Bruno Constantin, Aurélien Chatelier, Jean Chemin, Serge Urbach, Martial Seveno, Szimonetta Hideg, Chantal Ripoll, Kasandra Aguilar‐Cázarez, Min Zheng, Guo‐Hao Huang, Sheng‐Qing Lv, Lei Zhang, Philippe Rondard, Laurent Prezeau, Jean‐Philippe Pin, Hugues Duffau, Luc Bauchet, Valérie Rigau, Franck Denat, Charles Truillet, Didier Boquet, Jean‐Philippe Hugnot   +36 more
wiley   +1 more source

Real Time and Multiple Location Radon (222Rn) Monitoring System

Advances in Electrical and Computer Engineering, 2010
The paper presents a Radon monitoring system. The system is designed for real time multiple location monitoring. The paper presents in the first part a method and an instrument for measuring radon concentration in air.
MORARIU, G., GERIGAN, C., ROMANCA, M., OGRUTAN, P. L., ACIU, L. E.   +4 more
doaj   +1 more source

Real-Time Monitoring of Passenger’s Psychological Stress

Future Internet, 2019
This article addresses the question of passengers’ experience through different transport modes. It presents the main results of a pilot study, for which stress levels experienced by a traveller were assessed and predicted over two long journeys ...
Gaël Vila, Christelle Godin, Oumayma Sakri, Etienne Labyt, Audrey Vidal, Sylvie Charbonnier, Simon Ollander, Aurélie Campagne   +7 more
doaj   +1 more source