Results 81 to 90 of about 3,239,789 (298)

AAA+ protein unfoldases—the Moirai of the proteome

open access: yesFEBS Letters, EarlyView.
AAA+ unfoldases are essential molecular motors that power protein degradation and disaggregation. This review integrates recent cryo‐electron microscopy (cryo‐EM) structures and single‐molecule biophysical data to reconcile competing models of substrate translocation.
Stavros Azinas, Marta Carroni
wiley   +1 more source

Analysis of Fatigue Monitoring of Deepwater Drilling Riser

open access: yesShiyou jixie, 2017
The riser is the key equipment for deepwater drilling, which is prone to fatigue damage in harsh deepwater environment, so it is very important to monitor the fatigue of deepwater riser.
Li Qingpei   +5 more
doaj  

Real-Time Monitoring of Passenger’s Psychological Stress

open access: yesFuture Internet, 2019
This article addresses the question of passengers’ experience through different transport modes. It presents the main results of a pilot study, for which stress levels experienced by a traveller were assessed and predicted over two long journeys ...
Gaël Vila   +7 more
doaj   +1 more source

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

open access: yesMolecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon   +13 more
wiley   +1 more source

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

open access: yesMolecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla   +10 more
wiley   +1 more source

Monitoring Kualitas Air Secara Real-Time Terintegrasi

open access: yesJurnal Elektronika dan Telekomunikasi, 2016
Perkembangan budi daya ikan yang menggunakan keramba jaring apung (KJA), saat ini tersebar di berbagai waduk dan danau di seluruh Indonesia, saat ini tumbuh pesat dan menjadi andalan pendapatan daerah.
Yudi Yuliyus Maulana   +3 more
doaj   +1 more source

Infrared laser sampling of low volumes combined with shotgun lipidomics reveals lipid markers in palatine tonsil carcinoma

open access: yesMolecular Oncology, EarlyView.
Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff   +11 more
wiley   +1 more source

Perfect and Imperfect Real-Time Monitoring in a Minimum-Effort Game [PDF]

open access: yes
This paper presents the results from a minimum-effort game in which individuals can observe the choices of others in real time. We find that under perfect monitoring almost all groups coordinate at the payoff-dominant equilibrium.
Cary Deck, Nikos Nikiforakis
core  

Densely distributed and real-time scour hole monitoring using piezoelectric rod sensors [PDF]

open access: yes, 2019
This study aims to validate a piezoelectric driven-rod scour monitoring system that can sense changes in scour depth along the entire rod at its instrumented location.
Funderburk, Morgan L   +3 more
core  

Phenotypic and genotypic characterization of single circulating tumor cells in the follow‐up of high‐grade serous ovarian cancer

open access: yesMolecular Oncology, EarlyView.
Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon   +9 more
wiley   +1 more source

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