Results 121 to 130 of about 21,652,291 (267)

Real Time Satellite Clocks in Precise Point Positioning

, 2010
Computing a position with Single Frequency Precise Point Positioning (SF-PPP) algorithms compels to the use of satellite clock corrections, and for use with real-time applications, only a limited set of sources for orbit and clock data is available ...
Hauschild, André, Verhagen, Sandra, van Bree, Roel   +2 more
core  

Translating whole‐genome doubling into precision medicine in cancer

Molecular Oncology, EarlyView.
Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley   +1 more source

Real-time precise point positioning performance in Hong Kong during May 2024 space weather events

Journal of Space Weather and Space Climate
Space weather events are the primary drivers of ionospheric variations. These variations challenge conventional GNSS algorithms’ ionospheric processing strategies, leading to degraded positioning accuracy.
Sun Mengfei, Liu Tong, Liu Jian, Zhang Kun, Huang Junting, Chen Bo   +5 more
doaj   +1 more source

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source

PANoptosis in the pathogenesis of myelodysplastic syndromes

Molecular Oncology, EarlyView.
PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla, Jyoti Lamichhane, Cameron Lewis, Peter Breslin, Jiwang Zhang   +4 more
wiley   +1 more source

Real-Time Precise Point Positioning in NAD83: Global and Regional Broadcast Corrections Compared

, 2013
Real-time precise point positioning (PPP) is possible through the availability of the real-time satellite orbit and clock corrections to broadcast ephemeris, the real-time broadcast corrections (BCs).
C. Hu (753181), L. Huisman (3282606), Peter Teunissen (20002758)   +2 more
core  

Spatial biology in cancer epigenetics

Molecular Oncology, EarlyView.
Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley   +1 more source

Real Time Satellite Clocks in Single Frequency Precise Point Positioning

, 2010
Computing a position with Single Frequency Precise Point Positioning (SF-PPP) algorithms compels to the use of satellite clock corrections, and for use with real-time applications, only a limited set of sources for orbit and clock data is available ...
van Bree, R.J.P., Tiberius, C.C.J.M, Hauschild, A.   +2 more
core  

Intrapatient tumour heterogeneity and clonal evolution in an autopsy study of metastatic salivary gland cancer

Molecular Oncology, EarlyView.
Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche, Niels J. van Ruitenbeek, Charlotte Adang, Luke O'Gorman, Pui Yuen Lee, Willemijn M. Klein, Adriana C. H. van Engen‐van Grunsven, Jack A. Schalken, Sander Bervoets, Gerald W. Verhaegh, Carla M. L. van Herpen   +10 more
wiley   +1 more source

Near real-time comparison and monitoring of time scales with precise point positioning using NRCan ultra-rapid products

, 2012
This paper experimentally evaluates the assessment of precise point positioning (PPP) using the Natural Resources Canada (NRCan) Ultra-Rapid GPS products to serve as a short latency time-transfer tool to assist timing laboratories in operational ...
Mireault, Yves, TAVELLA, PATRIZIA, Cerretto, G., Lahaye, F., Rovera, Daniele, CERRETTO, GIANCARLO, Mireault, Y., Lahaye, François, Tavella, P., Rovera, D.   +9 more
core   +1 more source