Results 181 to 190 of about 17,110,106 (300)
Predicting postoperative delirium after lung cancer resection: the utility of synthetic data and LIME algorithm for model interpretation. [PDF]
Sci RepZhu Y, Liang R, Yang JJ, Zhou CM.
europepmc +1 more source
Reptes reals, aprenentatge real
El Aprendizaje Basado en Retos es una metodología educativa que coloca a los estudiantes frente a problemas reales y, a la vez, transforma el papel del docente. El enfoque pedagógico, la integración de la tecnología, la conexión con la industria y el apoyo y desarrollo de los estudiantes son aspectos clave a incorporar en la docencia para que el ...
Galdames Calderón, Marisol|| +1 more
openaire +1 more source
ATF4‐mediated stress response as a therapeutic vulnerability in chordoma
Molecular Oncology, EarlyView.We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone +11 more
wiley +1 more source
Molecular Oncology, EarlyView.The cancer problem is increasing globally with projections up to the year 2050 showing unfavourable outcomes in terms of incidence and cancer‐related deaths. The main challenges are prevention, improved therapeutics resulting in increased cure rates and enhanced health‐related quality of life.
Ulrik Ringborg +43 more
wiley +1 more source
A Clinically Oriented Framework for Real-Time Heart Rate Variability Analysis: A Novel Approach To Personalized and Robust Monitoring. [PDF]
J Med SystNakano T +3 more
europepmc +1 more source
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
A Real-Time Mobile Robotic System for Crack Detection in Construction Using Two-Stage Deep Learning. [PDF]
Sensors (Basel)Ogun E, Voeurn YA, Lee D.
europepmc +1 more source
LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro
Molecular Oncology, EarlyView.Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix +13 more
wiley +1 more source
Isothermal real-time RT-RPA for Machupo virus detection: Field-adaptable sensitivity comparable with laboratory PCR. [PDF]
PLoS OneKapitonova MA +5 more
europepmc +1 more source