Results 41 to 50 of about 9,824,063 (250)

Liver organoids: modelling complexity in homeostasis and disease

open access: yesFEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

RTXlet: uma abordagem de tempo real para aplicações de tv digital baseadas em Xlets [PDF]

open access: yes, 2006
Dissertação (mestrado) - Universidade Federal de Santa Catarina, Centro Tecnológico. Programa de Pós-graduação em Engenharia ElétricaEste trabalho propõe uma nova abordagem para aplicações de TV Digital.
Hartke Neto, Roberto
core  

Emerging experimental and computational methods for studying redox‐regulated structural transitions

open access: yesFEBS Letters, EarlyView.
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass   +2 more
wiley   +1 more source

From junk to function — How weak selection in eukaryotes builds new parts and drives genomic complexity

open access: yesFEBS Letters, EarlyView.
How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley   +1 more source

The Real Cost of HLB in Florida

open access: yesEDIS, 2019
I estimated the cultural cost per acre of managing HLB in orange citrus groves in Florida to be $663, which represents a 67% increase compared to pre-HLB levels.
Ariel Singerman
doaj  

Abolitionist memory work in The Real Cost of Prisons Comix

open access: yesMemory, Mind & Media
In this article, we identify the comics of the Real Cost of Prisons Project as graphic memory work that denaturalises ‘penal common sense’ and engages in graphic witnessing.
Duygu Erbil, Eamonn Connor
doaj   +1 more source

Moving and handling in the community: The real cost of an informal carer

open access: yesPielęgniarstwo XXI Wieku, 2018
MOVING AND HANDLING IN THE COMMUNITY: THE REAL COST OF AN INFORMAL CARER Introduction. Musculoskeletal disorders (MSDs) are the leading cause of work disability, sickness absence from work, and loss of productivity in healthcare across all the European
Jamie Wyton
doaj   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

open access: yesMolecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim   +3 more
wiley   +1 more source

A low‐computational‐cost alternating switches algorithm for real‐valued spatial covariance matrix reconstruction

open access: yesElectronics Letters, 2022
The application of the emerging hybrid analog–digital architecture for future millimeter‐wave communications has attracted significant attention. Although this architecture can reduce the hardware cost and power consumption considerably, the high ...
Changzan Liu, Yan Zhou, Bo Dang
doaj   +1 more source

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

open access: yesMolecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur   +11 more
wiley   +1 more source

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